Abstract
This study is a double “blind” prospective evaluation of the efficacy of dextran 40 (Rheomakrodex, Fa. Knoll, Ludwigshafen) in the treatment of acute pancreatitis. Sixty-five patients with acute pancreatitis were randomly divided into dextran and nondextran treatment groups. The two groups were comparable at the outset of the study and except for dextran 40 received identical therapy. These data indicate that prophylactic use of low molecular weight dextran in the treatment of acute pancreatitis can influence the course and the outcome of type I and type II pancreatitis. Hemorrhagic necrotizing pancreatitis without viable pancreatic tissue, however, cannot be influenced by dextran 40.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Becker H, Vinten-Johansen J, Buckberg GD (to be published) Correlation of pancreatic blood flow and high energy phosphates during experimental pancreatitis. J Surg Res
Donaldson LA, Williams RW, Schenck WG (1978) Experimental pancreatitis: effect of plasma and dextran on pancreatic blood flow. Surgery 84: 313
Farrar WH, Calkins WG (1978) Sensitivity of the amylase-creatinine-clearance ratio in acute pancreatitis. Arch Intern Med 138: 958
Goebell H (1970) Diagnostische Möglichkeiten mit der Bestimmung von Amylase und Lipase in Körperflüssigkeiten. Internist 11: 117
Goebell H, Hotz J (1979) Akute Pankreatitis — Gesichertes und Ungesichertes in der Behandlung. Dtsch Aerztebl 38: 2399
Goodhead B (1969) Vascular factors in the pathogenesis of acute hemorrhagic pancreatitis. Ann R Coll Surg Engl 45: 80
Goodhead B, Wright PW (1970) The value of dextran in the treatment of experimental pancreatitis, Surgery 67: 807
Levine RJ, Glanser FC, Berk JE (1975) Enhancement of the amylase-creatinine-clearance ratio in disorders other than acute pancreatitis. N Engl J Med 292: 329
Paul F, Ohnhaus EE, Hesch RD, Chemnitz G, Hoppe-Seyler R, Henrichs HR, Hartung H, Waldmann D, Kunze K, Barth E, Niiesch E, Abt K (1979) Einfluß von Salm-Calcitonin auf den Verlauf dei akuten Pankreatitis. Dtsch Med Wochenschr 17: 615
Schönborn H, Pross E, Obermann M (1975) Neuere Vorstellungen zur konservativen und operativer Therapie der akuten Pankreatitis. Internist 16: 108
Thal AP, Peny JF, Egner WA (1957) Clinical and morphologic study of 42 cases of fatal acute pancreatitis. Surg Gynecol Obstet 105: 191
Trapnell JE, Rigby CC, Talbot CH, Duncan EHL (1974) A controlled trial of Trasylol in the treatment of acute pancreatitis. Br J Surg 61: 177
Warshaw AL, Fuller AF (1975) Specificity of increased renal clearance of amylase in diagnosis of acute pancreatitis. N Engl J Med 292: 325
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Becker, H., Ruf, W., Hissen, W., Junghanns, K. (1982). A Prospective Study to Determine the Efficacy of Dextran 40 in Acute Pancreatitis. In: Hollender, L.F. (eds) Controversies in Acute Pancreatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68518-7_39
Download citation
DOI: https://doi.org/10.1007/978-3-642-68518-7_39
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-11410-9
Online ISBN: 978-3-642-68518-7
eBook Packages: Springer Book Archive