Proteinase Inhibitors of Microbial Origin in the Treatment of Experimental Acute Haemorrhagic Pancreatitis

  • A. Jones
  • D. A. W. Grant
  • J. Hermon-Taylor
Conference paper


It is generally accepted that the basic pathogenetic principle responsible for damage of pancreatic tissue in acute pancreatitis is autodigestion (3). The inappropriate release of activated exocrine enzymes into the surrounding tissues, peritoneal cavity and circulation results in metastatic proteolysis and its pathophysiological consequences (12, 5, 4, 2). Active proteinases in the blood stream become complexed with macromolecular inhibitors, predominantly alpha 2 macroglobulin (11). Although constrained, the alpha 2 macroglobulin bound proteinase retains enzymic activity which is likely to contribute substantially to the metabolic defects in severe acute pancreatitis (10). For example, alpha 2 macroglobulin-trypsin rapidly abolished the bioactivity of endogenous parathormone in human plasma (6) Inhibition of this reaction was completed by low concentrations of leupeptin, a proteinase inhibitor of microbial origin, but not by Trasylol (6).


Acute Pancreatitis Severe Acute Pancreatitis Sodium Taurocholate Microbial Origin Inappropriate Release 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • A. Jones
  • D. A. W. Grant
  • J. Hermon-Taylor

There are no affiliations available

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