Effect of Cadmium and Phenobarbital on Cerebral Aldehyde Reductase

  • M. Baumann
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 5)

Abstract

The effect of cadmium (Cd), phenobarbital and of a combination of both on the aldehyde reductase of rat brain cytosol was investigated in vitro. Cd as well as phenobarbital inhibited the enzyme. A combination of both chemicals resulted in an additive inhibition. From these results it is concluded, that only in heavily contaminated people will an interaction between Cd and phenobarbital on the aldehyde reductase level in the brain occur.

Key words

Aldehyde reductase Brain Inhibition Cadmium Phenobarbital 

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References

  1. Erwin VG, Deitrich RA (1973) Inhibition of bovine brain aldehyde reductase by anticonvulsant compounds in vitro. Biochem Pharmacol 22: 2615–2624CrossRefGoogle Scholar
  2. Schnell RC, Yuhas EM, Pence DH, Means JR, Roberts SA, Yau ET, Miya TS, Mennear JH (1978) Effect of acute and chronic cadmium treatment on hepatic drug metabolism in male rats. Arch Toxicol 40: 269–277PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • M. Baumann
    • 1
  1. 1.Department of ToxicologyGesellschaft für Strahlen- und UmweltforschungNeuherbergFederal Republic of Germany

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