Abstract
Circulating platelets can potentially interact with only one element of the intact vessel wall — the endothelial cells which cover the luminal surface of the vessel in a continuous monolayer. In the injured regions of the vessel the platelets contact other cellular and macromolecular components of the vascular wall, depending on the extent of the damage. In shallow superficial damage (e.g., at a focal loss of one or several endothelial cells) the platelets interact with the subendothelial components: amorphous and fibrillar collagen, elastin, and microfibrils [1, 2, 3]. In deeper damage and frank vascular trauma, the platelets contact the cells and macromolecular structures of the intima, media, and adventitia [4]. Smooth muscle cells of the intima, media, and fibrillar collagen are exposed to direct interaction with platelets at ulceration and fissures in atherosclerotic plaques [5,6].
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Ljubimova, E.V., Orekhov, A.N., Leytin, V.L. (1982). Adhesive and Thrombogenic Properties of Human Vascular Wall Cells in Culture. In: Chazov, E.I., Smirnov, V.N. (eds) Vessel Wall in Athero- and Thrombogenesis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68502-6_19
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DOI: https://doi.org/10.1007/978-3-642-68502-6_19
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-11384-3
Online ISBN: 978-3-642-68502-6
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