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Peptides: Pancreatic Hormones

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Book cover Mediators and Drugs in Gastrointestinal Motility II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 59 / 2))

Abstract

The pancreatic hormone glucagon, well known essentially for its metabolic effects, has also been used as a pharmacologic tool in different conditions: as a provocative test for pheochromocytoma, as a stimulus for growth hormone release, in the treatment of uncomplicated insulin-induced and sulfonylurea-induced hypoglycemia, and in some cases of acute heart failure in which myocardial tissue is essentially healthy. From a chemical point of view glucagon is a member of the so-called secretin family and it shares 14 positionally identical amino acids with secretin (see Table 1 in Chap. 2a, Secretin), suggesting that these two peptides may have a common ancestral gene and that their structure may contain a still undeciphered message of phylogenetic and physiologic significance (for reviews see Lefebvre and Unger 1972; Foà et al. 1977). No wonder that their effects have so many points in common: both stimulate the secretion of insulin, inhibit gastric secretion, and exert a predominant inhibitory effect on gastrointestinal motility. This latter effect will be described in detail.

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Authors
  1. G. Bertaccini
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Editors and Affiliations

  1. School of Medicine, University of Parma, I-43100, Parma, Italy

    Giulio Bertaccini M.D. (Head of the Department of Pharmacology) (Head of the Department of Pharmacology)

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© 1982 Springer-Verlag Berlin Heidelberg

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Bertaccini, G. (1982). Peptides: Pancreatic Hormones. In: Bertaccini, G. (eds) Mediators and Drugs in Gastrointestinal Motility II. Handbook of Experimental Pharmacology, vol 59 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68474-6_4

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  • DOI: https://doi.org/10.1007/978-3-642-68474-6_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68476-0

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