The concept of repair processes in multiple sclerosis, especially those which relate to neuronal-glial cell interactions, can be considered on several different levels. Eventually it may be possible to document an initial insult in man which leads directly or indirectly to the eventual development of the symptoms of multiple sclerosis. Repair at the most basic level might be directed at elimination of this insult be it caused by viral, humoral, or other factors. It is also probable that secondary immunologic or other host-reactive mechanisms may become established as a result of this initial process which in themselves lead to the persistence of the disease state or to its re-appearance or exacerbation. Repair might be conceived as involving intervention at this point in the train of pathophysiologic events. Eventually the formation of lesions within the substance of the central nervous system leads to the characteristic symptomatic expressions of the disease in man. The concept of repair might be considered to involve the restoration of normal function in the fiber tracts affected by demyelination and axonal loss.
KeywordsMultiple Sclerosis Schwann Cell Diphtheria Toxin Bergmann Glia Oligodendroglial Cell
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