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The Template Effect

  • George W. Gokel
  • Stephen H. Korzeniowski
Part of the Reactivity and Structure Concepts in Organic Chemistry book series (REACTIVITY, volume 13)

Abstract

It has been axiomatic for many years that large rings must be prepared under high dilution conditions so that the probability of the two ends meeting exceeds the probability of linear polymer formation7. It therefore seems remarkable that many of the syntheses of macrocyclic polyethers which have been reported involve less than dilute if not very concentrated conditions18. The success of these large-ring intramolecular SN2 reactions is generally attributed to the operation of a “template” effect during crown synthesis.

Keywords

Crown Ether Macrocyclic Lactone Triethylene Glycol Lithium Cation Tetrahedron Letter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • George W. Gokel
    • 1
  • Stephen H. Korzeniowski
    • 2
  1. 1.Department of ChemistryUniversity of MarylandCollege ParkUSA
  2. 2.Chemicals and Pigments Department, Jacson LaboratoryE. I. Du Pont de Nemours Co., Inc.DeepwaterUSA

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