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Genetic Determinants of Autoimmune Chronic Active Hepatitis

  • Ian R. Mackay
  • Senga Whittingham
  • John D. Mathews
  • Brian D. Tait

Abstract

There has been a remarkable vindication over the past 15 years of Burnet’s forecast, with two particular themes of dominant interest to research on immunogenetics. The first is the association in inbred animals between genetic control of immune responses to antigens of limited heterogeneity and genes (Ir genes) of the major histocompatibility complex (MHC) [2, 39]. The second is the increasing refinement of typing methods for human histocompatibility antigens, of relevance to tissue transplantation, and associations between certain immunopathic diseases and HLA specificities [26, 31]. However, despite much experimental work and theoretical speculation, no unifying concept relating MHC-linked Ir genes effects and MHC- linked disease susceptibility has yet emerged.

Keywords

Major Histocompatibility Complex Primary Biliary Cirrhosis Chronic Active Hepatitis Chronic Active Liver Disease Lupoid Hepatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • Ian R. Mackay
    • 1
    • 4
  • Senga Whittingham
    • 1
    • 4
  • John D. Mathews
    • 2
    • 4
  • Brian D. Tait
    • 3
  1. 1.Clinical Research UnitWalter and Eliza Hall Institute of Medical Research and the Royal Melbourne HospitalUSA
  2. 2.Department of MedicineThe University of MelbourneUSA
  3. 3.The Tissue Typing LaboratoryRoyal Melbourne HospitalUSA
  4. 4.National Health and Medical Research CouncilAustralia

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