Abstract
The mammalian leukemia viruses and the avian leukosis viruses produce tumors in animals after long latent periods. In contrast, the acute transforming retroviruses produce a variety of neoplasias within weeks of infection. These latter viruses differ from the leukemia viruses in that they possess specific sequences (one) that share homology with normal host cellular DNA (for reviews see Tooze l973; Duesberg1919). These one sequences appear to be transduced from the host cell into rescuable viral genomes. Their presence in the virus confers a specific transformed phenotype to the infected host cell or animal. We have been interested in how retroviruses interact with one sequences to effect a transformed phenotype.
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© 1982 Springer-Verlag Berlin Heidelberg
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Robinson, H.L., Woude, G.F.V. (1982). The Genetic Basis of Retroviral-Induced Transformation. In: Wecker, E., Horak, I. (eds) Retrovirus Genes in Lymphocyte Function and Growth. Current Topics in Microbiology and Immunology, vol 98. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68369-5_2
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DOI: https://doi.org/10.1007/978-3-642-68369-5_2
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