Sleep pp 37-81 | Cite as

Endocrine and Peptide Functions in the Sleep-Waking Cycle

  • René Drucker-Colín
  • Carlos Valverde-R
Part of the Current Topics in Neuroendocrinology book series (CT NEUROENDOCRI, volume 1)


Ever since the landmark discovery of Aserinsky and Kleitman (1953) that certain periods of sleep were accompanied by conjugate rapid eye movements (REM), which made it possible to distinguish between two phases of sleep, physiologists have been concerned with finding their neurohumoral counterparts. For many years this aspect was dominated by the monoamine theory of sleep, largely due to the very elegant series of experiments carried out by Jouvet and his group (1972). In recent years, partly due to some conflicting evidence bearing on the monoamine theory (Drucker-Colin and Spanis 1976; Gillin et al. 1978; Ramm 1979) and partly due to the enormous interest generated in the neurosciences by hormones and peptides, this theory has fallen slightly into disfavor. This state of affairs should not be taken to signify that the monoamines do not play a role in sleep, but rather that their role should no longer be conceived as being of central importance, since in all probability sleep depends on a number of systems.


Peptide Function Luteinizing Hormone Release Hormone Locus Coeruleus Delta Sleep Induce Peptide Arginine Vasotocin 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • René Drucker-Colín
    • 1
  • Carlos Valverde-R
    • 2
  1. 1.Depto. de Neurociencias, Centro de Investigaciones en Fisiologia CelularUniversidad Nacional Autónoma de MéxicoMéxico 20, D.F.Mexico
  2. 2.Depto. de Medicina Nuclear y Clinica de TiroidesInstituto Nacional de NutriciónMéxico 22, D.F.México

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