Part of the Advances in Neurosurgery book series (NEURO, volume 10)
Criteria for the Choice of Drugs Suitable for Controlled Hypotension in Neuroanaesthesia
Controlled hypotension for the improvement of intraoperative conditions is able to minimize operative blood loss, operative time and mortality as well as contributing to a shorter course of disease in patients undergoing neurosurgical procedures. Besides volatile anaesthetic agents (e.g. halothane), two groups of chemical substances are commonly used, which achieve low pressure conditions, either via a direct relaxing effect on vascular smooth muscle cells or by blocking ganglia belonging to the autonomic nervous system. In order to meet the essential requirements of the anaesthetist confronted with critical intraoperative conditions, the drug producing hypotension should ideally have the following basic properties:
easy to control,
no increase of intracerebral blood volume,
no change in cerebral blood flow (CSF) autoregulation,
KeywordsCerebral Blood Flow Sodium Nitroprusside Mean Arterial Blood Pressure Systemic Hypotension Control Hypotension
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer-Verlag Berlin · Heidelberg 1982