Skip to main content

Relationship of Age and Serum Cholesterol to Platelet Survival Time in Men with Coronary Artery Disease

  • Conference paper
Myocardial Infarction at Young Age

Abstract

It seems likely that platelets contribute to the pathogenesis of atherosclerotic coronary artery disease (CAD) and its complications [1–3] and platelet survival is shortened in most patients with CAD [4, 5]. Platelet survival, in relation to age, in men with CAD has not been previously studied. It is possible that younger patients with “premature atherosclerosis” have altered platelet reactivity which contributes to the early development of critical coronary artery lesions [2]. The purpose of this study was to determine whether any relationship exists between platelet survival and age in men with angiographically defined CAD. Since hyperlipidemia is an important risk factor for the CAD development [6] and can affect platelet survival time [7], serum cholesterol was also included in the analysis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. French JE (1971) Atherogenesis and thrombosis. Semin Hematol 8: 84

    PubMed  CAS  Google Scholar 

  2. Roberts WC (1973) Does thrombosis play a major role in the development of symptom-producing atherosclerotic plaques? Circulation 48: 1161

    Google Scholar 

  3. Harker LA, Ross R, Slichter SJ, Scott CR (1976) Homocystine-induced arteriosclerosis: The role of endothelial injury and platelet response in its genesis. J Clin Invest 58: 731

    Article  PubMed  CAS  Google Scholar 

  4. Steele P, Battock D, Genton E (1975) Effects of Clofibrate and sulfinpyrazone on platelet survival time in coronary artery disease. Circulation 52: 473

    PubMed  CAS  Google Scholar 

  5. Ritchie JL, Harker LA (1977) Platelet and fibrinogen survival in coronary atherosclerosis: Response to medical and surgical therapy. Am J Cardiol 39: 595

    Article  PubMed  CAS  Google Scholar 

  6. Kannel WB, Castelli WP, McNamar PM (1967) The coronary profile: 12-year follow-up in the Framingham study. J Med 9: 611

    CAS  Google Scholar 

  7. Steele P, Rainwater (1978) Effects of dietary and pharmacologic alteration of serum lipids on platelet survival time. Circulation 58: 365

    PubMed  CAS  Google Scholar 

  8. Carvalho AC, Colman RW, Lees RS (1974) Platelet function in hyperlipoproteinemia. N Engl J Med 290: 434

    Article  PubMed  CAS  Google Scholar 

  9. Shattil SJ, Anaya-Galindo R, Bennett J et al. (1975) Platelet hypersensitivity induced by cholesterol incorporation. J Clin Invest 55: 636

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Gold, F., Steele, P. (1981). Relationship of Age and Serum Cholesterol to Platelet Survival Time in Men with Coronary Artery Disease. In: Roskamm, H. (eds) Myocardial Infarction at Young Age. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68294-0_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-68294-0_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68296-4

  • Online ISBN: 978-3-642-68294-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics