Relationship of Age and Serum Cholesterol to Platelet Survival Time in Men with Coronary Artery Disease

  • F. Gold
  • P. Steele


It seems likely that platelets contribute to the pathogenesis of atherosclerotic coronary artery disease (CAD) and its complications [1–3] and platelet survival is shortened in most patients with CAD [4, 5]. Platelet survival, in relation to age, in men with CAD has not been previously studied. It is possible that younger patients with “premature atherosclerosis” have altered platelet reactivity which contributes to the early development of critical coronary artery lesions [2]. The purpose of this study was to determine whether any relationship exists between platelet survival and age in men with angiographically defined CAD. Since hyperlipidemia is an important risk factor for the CAD development [6] and can affect platelet survival time [7], serum cholesterol was also included in the analysis.


Serum Cholesterol Serum Cholesterol Level Endothelial Injury Platelet Reactivity High Serum Cholesterol 
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  1. 1.
    French JE (1971) Atherogenesis and thrombosis. Semin Hematol 8: 84PubMedGoogle Scholar
  2. 2.
    Roberts WC (1973) Does thrombosis play a major role in the development of symptom-producing atherosclerotic plaques? Circulation 48: 1161Google Scholar
  3. 3.
    Harker LA, Ross R, Slichter SJ, Scott CR (1976) Homocystine-induced arteriosclerosis: The role of endothelial injury and platelet response in its genesis. J Clin Invest 58: 731PubMedCrossRefGoogle Scholar
  4. 4.
    Steele P, Battock D, Genton E (1975) Effects of Clofibrate and sulfinpyrazone on platelet survival time in coronary artery disease. Circulation 52: 473PubMedGoogle Scholar
  5. 5.
    Ritchie JL, Harker LA (1977) Platelet and fibrinogen survival in coronary atherosclerosis: Response to medical and surgical therapy. Am J Cardiol 39: 595PubMedCrossRefGoogle Scholar
  6. 6.
    Kannel WB, Castelli WP, McNamar PM (1967) The coronary profile: 12-year follow-up in the Framingham study. J Med 9: 611Google Scholar
  7. 7.
    Steele P, Rainwater (1978) Effects of dietary and pharmacologic alteration of serum lipids on platelet survival time. Circulation 58: 365PubMedGoogle Scholar
  8. 8.
    Carvalho AC, Colman RW, Lees RS (1974) Platelet function in hyperlipoproteinemia. N Engl J Med 290: 434PubMedCrossRefGoogle Scholar
  9. 9.
    Shattil SJ, Anaya-Galindo R, Bennett J et al. (1975) Platelet hypersensitivity induced by cholesterol incorporation. J Clin Invest 55: 636PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • F. Gold
  • P. Steele
    • 1
  1. 1.Cardiology Division, Department of Medicine, Veterans Administration Medical CenterUniversity of Colorado Health Sciences CenterDenverUSA

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