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Relationship of Age and Serum Cholesterol to Platelet Survival Time in Men with Coronary Artery Disease

  • F. Gold
  • P. Steele

Abstract

It seems likely that platelets contribute to the pathogenesis of atherosclerotic coronary artery disease (CAD) and its complications [1–3] and platelet survival is shortened in most patients with CAD [4, 5]. Platelet survival, in relation to age, in men with CAD has not been previously studied. It is possible that younger patients with “premature atherosclerosis” have altered platelet reactivity which contributes to the early development of critical coronary artery lesions [2]. The purpose of this study was to determine whether any relationship exists between platelet survival and age in men with angiographically defined CAD. Since hyperlipidemia is an important risk factor for the CAD development [6] and can affect platelet survival time [7], serum cholesterol was also included in the analysis.

Keywords

Serum Cholesterol Serum Cholesterol Level Endothelial Injury Platelet Reactivity High Serum Cholesterol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • F. Gold
  • P. Steele
    • 1
  1. 1.Cardiology Division, Department of Medicine, Veterans Administration Medical CenterUniversity of Colorado Health Sciences CenterDenverUSA

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