Abstract
It seems likely that platelets contribute to the pathogenesis of atherosclerotic coronary artery disease (CAD) and its complications [1–3] and platelet survival is shortened in most patients with CAD [4, 5]. Platelet survival, in relation to age, in men with CAD has not been previously studied. It is possible that younger patients with “premature atherosclerosis” have altered platelet reactivity which contributes to the early development of critical coronary artery lesions [2]. The purpose of this study was to determine whether any relationship exists between platelet survival and age in men with angiographically defined CAD. Since hyperlipidemia is an important risk factor for the CAD development [6] and can affect platelet survival time [7], serum cholesterol was also included in the analysis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
French JE (1971) Atherogenesis and thrombosis. Semin Hematol 8: 84
Roberts WC (1973) Does thrombosis play a major role in the development of symptom-producing atherosclerotic plaques? Circulation 48: 1161
Harker LA, Ross R, Slichter SJ, Scott CR (1976) Homocystine-induced arteriosclerosis: The role of endothelial injury and platelet response in its genesis. J Clin Invest 58: 731
Steele P, Battock D, Genton E (1975) Effects of Clofibrate and sulfinpyrazone on platelet survival time in coronary artery disease. Circulation 52: 473
Ritchie JL, Harker LA (1977) Platelet and fibrinogen survival in coronary atherosclerosis: Response to medical and surgical therapy. Am J Cardiol 39: 595
Kannel WB, Castelli WP, McNamar PM (1967) The coronary profile: 12-year follow-up in the Framingham study. J Med 9: 611
Steele P, Rainwater (1978) Effects of dietary and pharmacologic alteration of serum lipids on platelet survival time. Circulation 58: 365
Carvalho AC, Colman RW, Lees RS (1974) Platelet function in hyperlipoproteinemia. N Engl J Med 290: 434
Shattil SJ, Anaya-Galindo R, Bennett J et al. (1975) Platelet hypersensitivity induced by cholesterol incorporation. J Clin Invest 55: 636
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Gold, F., Steele, P. (1981). Relationship of Age and Serum Cholesterol to Platelet Survival Time in Men with Coronary Artery Disease. In: Roskamm, H. (eds) Myocardial Infarction at Young Age. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68294-0_20
Download citation
DOI: https://doi.org/10.1007/978-3-642-68294-0_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-68296-4
Online ISBN: 978-3-642-68294-0
eBook Packages: Springer Book Archive