Intrathecally Applied Morphine for Treatment of Postoperative and Chronic Pain
Eleven patients suffering from metastases to the lumbar spine or pelvis received multiple intrathecal injections of 0.5–1.5 mg morphine. The first injection produced pain relief for 18–84 hours. A hypoalgesia following the intrathecal injection persisted up to 4 days. No change in blood pressure or heart rate was noted.