Pain Relief with Morphine, Applied Intrathecally or Epidural

  • J. Sarubin
  • E. Gebert
Part of the Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine book series (A+I, volume 144)


To examine the effects of intrathecal and epidural opiates, three groups of patients were examined. Group I consisted of patients suffering from chronic cancer and multiple rib fractures and received intrathecal morphine (1 mg/2 ml in 5% glucose, intrathecal). Group II consisted of patients who underwent abdominal surgery and received intrathecal morphine (1 to 2 mg/2 ml glucose) (before anaesthesia). Group III was a second postoperative group which received epidural morphine (4 mg/10 to 20 ml saline). Group I patients showed a mean pain relief of 25 hrs which began approximately 20 min after the injection. In this group, no side effects including respiratory depression were observed. Group II showed a mean postoperative pain relief of 33 hrs. In this group, three patients showed significant respiratory depression which was naloxone antagonizable. Group III showed a mean postoperative pain relief of 16 hours. No respiratory depression was observed.


Pain Relief Respiratory Depression Epidural Morphine Intrathecal Morphine Postoperative Pain Relief 
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  1. 1.
    Behar M, Olshwang D, Magora F, Davidson JT (1979) Epidural morphine in treatment of pain. Lancet 1:527PubMedCrossRefGoogle Scholar
  2. 2.
    Cousins MJ, Mather LE, Glynn CJ, Wilson PR, Graham JR (1979) Selective spinal analgesia. Lancet 1:1141PubMedCrossRefGoogle Scholar
  3. 3.
    Davies GK, Tolhorst-Cleaver CL, James TL (1980) CNS depression from intrathecal morphine. Anesthesiology 52:280PubMedCrossRefGoogle Scholar
  4. 4.
    Glynn CJ, Mather LE, Cousins MJ, Wilson PR, Graham JR (1979) Spinal narcotics and respiratory depression. Lancet 2:356PubMedCrossRefGoogle Scholar
  5. 5.
    Graham JL, King R, McCaughey W (1980) Postoperative pain relief using epidural morphine. Anaesthesia 31:158CrossRefGoogle Scholar
  6. 6.
    Johnston JR, McCaughey W (1980) Epidural morphine. A method of management of multiple fractures ribs. Anaesthesia 35:155PubMedCrossRefGoogle Scholar
  7. 7.
    Kerr FWL (1975) Neuroanatomical substrates of nociception in the spinal cord. Pain 1:325PubMedCrossRefGoogle Scholar
  8. 8.
    La Motte C, Pert CB, Snyder SH (1976) Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section. Brain Res 112:407CrossRefGoogle Scholar
  9. 9.
    Lebars D, Menetrey D, Conseiller C, Besson JM (1975) Depressive effects of morphine upon lamina 5 cell activity in the dorsal horn of the spinal cat. Brain Res 98:261CrossRefGoogle Scholar
  10. 10.
    Liolios A, Andersen FH (1979) Selective spinal analgesia. Lancet 2:357PubMedCrossRefGoogle Scholar
  11. 11.
    Oyama T, Jin T, Yamaya R, Ling N, Guillemin R (1980) Profound analgesie effects of β-endorphine in man. Lancet 1:122PubMedCrossRefGoogle Scholar
  12. 12.
    Scott DB, McClure J (1979) Selective epidural anaesthesia. Lancet 1:1410PubMedCrossRefGoogle Scholar
  13. 13.
    Snyder SH (1977) Opiate receptors and internal opiates. Scientific American 236:44PubMedCrossRefGoogle Scholar
  14. 14.
    Wang JK, Nauss LA, Thomas JE (1979) Pain relief by intrathecally applied morphine in man. Anesthesiology 50:149PubMedCrossRefGoogle Scholar
  15. 15.
    Wolfe MJ, Davis GK (1980) Analgesic action of extradural fentanyl. Brit J Anaesth 52:357PubMedCrossRefGoogle Scholar
  16. 16.
    Yaksh TL, Rudy TA (1976) Analgesia mediated by a direct spinal action of narcotic. Science 192:1357PubMedCrossRefGoogle Scholar
  17. 17.
    Zenz M, Piepenbrock S, Otten B, Otten G (1980) Epidurale Morphin-Injektion zur Schmerzbekämpfung. Fortschr Med 98:306PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • J. Sarubin
  • E. Gebert

There are no affiliations available

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