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Geriatrics 2 pp 102–142Cite as

The Aged Thyroid Gland

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Abstract

After diabetes mellitus, thyroid diseases are one of the most frequent endocrine disorders. There are established age-related changes in hyperthyroidism, hypothyroidism, and cancer of the thyroid, with hyperthyroidism and hypothyroidism giving rise to special diagnostic problems.

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References

  • Ackermann PG, Iversen K (1953) Radio-iodine excretion in the aged. J Gerontol 8:458

    PubMed  CAS  Google Scholar 

  • Aschoff L (1928) Berichte der Internationalen Kropfkonferenz Bern 1927. Huber Verlag, Bern

    Google Scholar 

  • Asher R (1949) Myxoedematous madness. Br Med J 2:555

    Article  PubMed  CAS  Google Scholar 

  • Aub JC, Du Bois (1917) Clinical calorymetry XIX, basal metabolism of old men. Arch Intern Med 19:823

    CAS  Google Scholar 

  • Azizi F, Vagenakis AG, Portnay GI, Rapoport B, Ingbar SH, Bravermann LE (1975) Pituitary-thyroid responsiveness to intramuscular thyrotropin releasing hormone based on analyses of serum thyroxine, trijodthyronine, and thyrotropin concentrations. N Engl J Med 292:273

    Article  PubMed  CAS  Google Scholar 

  • Bahemuka M, Hodgkinson HM (1975) Screening for hypothyroidism in elderly impatients. Br Med J 2:601

    Article  PubMed  CAS  Google Scholar 

  • Baker JT, Harvey RF (1971) Bowel habit in thyrotoxicosis and hypothyroidism. Br Med J 1:322

    Article  PubMed  CAS  Google Scholar 

  • Bansi HW (1967) Klinik der Schilddrüsenerkrankungen. In: Doberauer, Hittmair, Nissen, Schulz (eds) Hdb. der praktischen Geriatrie, Bd II. Ferd. Enke Verlag, Stuttgart Bartels EC (1954)Hyperthyroidism in patients over the age of sixty. Surg Clin North Am 34:673

    Google Scholar 

  • Bastenie PA, Ectors M, Thys JP, Vanhaelst L (1973) L-hypothyroidie spontaneé après 50 ans. Probl Acta Endocr Nutr 17(71):57

    Google Scholar 

  • Bastenie PA, Vanhaelst L, Goldstein J, Smets Ph (1977) Asymptomatic autoimmune thyroiditis and coronary heart disease. Lancet 2:155

    Article  PubMed  CAS  Google Scholar 

  • Berger M, Peyrin JO, Briere J (1968) Sur la frequence des hypothyroidies tardives après traitment de l’hyperthyroidie par le Jode 131. Presse Méd 76:607

    PubMed  CAS  Google Scholar 

  • Bermudez F, Surks MJ, Oppenheimer JH (1975) High incidence of decreased serum trijodthyronine concentrations in patients with nonthyroidal disease. J Clin Endocrinol Metab 41:27

    Article  PubMed  CAS  Google Scholar 

  • Bertheaux P, Bribet F (1968) Etiologie de l’insuffisance thyroidienne de l’adulte. Rev Pra (Paris) 18:2085

    Google Scholar 

  • Beumont PJV (1972) Endocrines and psychiatry. Br Hosp Med 4:485

    Google Scholar 

  • Binet L, Bourlière (1951) Additional data on the basal metabolism of the aged. Presse Méd 59:557

    PubMed  CAS  Google Scholar 

  • Blahôs J, Soumar (1975) The role of age in the development of hypothyroidism after treatment with radioiodine. Endocrinologie 69:2, 196

    Google Scholar 

  • Blum M (1972) Myxedema coma. Am J Med Sci 264:432

    Article  PubMed  CAS  Google Scholar 

  • Blum M, Weinberg U, Shenkman L, Hollander CS (1974) Hyperthyroidism after iodinated contrast medium. N Engl J Med 291:24

    Article  PubMed  CAS  Google Scholar 

  • Blum M, Shenkman L, Hollander CS (1975) The autonomous nodule of the thyroid. Correlation of patients age, nodule size, and functional status. Am J Med Sci 269:43

    Article  PubMed  CAS  Google Scholar 

  • Börner W, Eichner R, Reiners Ch, Ruppert G, Schaffhauser R, Seybold U (1978) Zur Diagnostik und Therapie des Schilddrüsenmalignoms. Ther. Woche 28:9272

    Google Scholar 

  • Bonnyns M, Bastenie PA (1967)Serum thyrotrophin in myxedema and asymptomatic atrophic thyroiditis. J Clin Endocrinol Metabol 27:849

    Article  CAS  Google Scholar 

  • Boohtby WM, Sandiford I (1929) Normal values of basal or standard metabolism. Am J Physiol 90:290

    Google Scholar 

  • Braverman LE, Dawber NA, Ingbar SH (1966) Observations concerning the binding of thyroid hormones in sera of normal subjects of varying ages. J Clin Invest 45:1273

    Article  PubMed  CAS  Google Scholar 

  • Braverman LE, Ingbar SH, Vagenakis AG, Adams L, Maloof F (1971) Enhanced susceptibility to iodide myxedema in patients with Hashimoto’s disease. J Clin Endocrinol Metab 32:515

    Article  PubMed  CAS  Google Scholar 

  • Breitner B (1928) Die Erkrankungen der Schilddrüse. Springer Verlag, Wien

    Google Scholar 

  • Britton KE, Ellis SM, Miralles JM, Quinn V, Cayly ACD, Brown BL, Ekins RP (1975) Is T 4 toxicosis a normal biochemical finding in elderly women? Lancet 2:141

    Article  PubMed  CAS  Google Scholar 

  • Brun R, Jenny M, Junod JP (1978) L’hyperthyréose des personnes agées. Schweiz Med Wo-chenschr 108:1504

    CAS  Google Scholar 

  • Brunelle P, Bohuon C (1972) Baisse de la triiodthyronine serique avec l’age. Clin Chim Acta 42:201

    Article  PubMed  CAS  Google Scholar 

  • Buchanan WWR, McHarden G, Koutras DA, Gray KG (1965) Abnormalities of iodine metabolism in euthyroid nongoitrous women with complement-fixing antimicrosomal thyroid auto-antibodies. J Clin Endocrinol Metab 25:301

    Article  PubMed  CAS  Google Scholar 

  • Bürgi H, Geiser J, Rosier H, Studer H (1978) Die verkannte Hyperthyreose beim Spitalpatienten. Schweiz Med Wochenschr 108:1257

    PubMed  Google Scholar 

  • Burger A, Suter P, Nicod P, Valloton MB, Vagenakis A, Braverman A (1976) Reduced active thyroid hormone levels in acute illness. Lancet 1:653

    Article  PubMed  CAS  Google Scholar 

  • Burke G, Silverstein E (1969) Hypothyroidism after treatment with sodium iodide J 131. JAMA 210:6, 1051

    Article  PubMed  CAS  Google Scholar 

  • Burrows AW, Shakespear RA, Hesch RD, Cooper E, Aickin CM, Burke CW (1975) Thyroid hormones in the elderly sick, “T 4 euthyroidism.” Br Med J 4:437

    Article  PubMed  CAS  Google Scholar 

  • Burstein J, Lamberg BA, Eramaa E (1960) Myocardial infarction in thyrotoxicosis. Acta Med Scand 166:379

    Article  PubMed  CAS  Google Scholar 

  • Caplan RH, Glasser JE, Davis K, Foster L, Wickus G (1978) Thyroid function tests in elderly hyperthyroid patients. J Am Geriatr Soc 26:3, 116

    PubMed  CAS  Google Scholar 

  • Catz B, Russel S (1961) Myxedema, shock, and coma. Seven survival cases. Arch Intern Med 108:407

    PubMed  CAS  Google Scholar 

  • Cavanagh Ch R (1958) The problem of thyroid nodule in an endemic goiter area. JAMA 167:2053

    Google Scholar 

  • Charcot M (1885) Maladie de Basedow (goitre exophthalmique) formes frustes nouveau signe physique, traitement par l’electricité. Gaz Hop 13:98

    Google Scholar 

  • Chen JH, Walfish PG (1978) Effects of age and ovarian function on the pituitary-thyroid system in female rats. J Endocrinol 78:225

    Article  PubMed  CAS  Google Scholar 

  • Clerc E (1912) Die Schilddrüse im hohen Alter. Z Pathol 10:1

    Google Scholar 

  • Clute HM, Swinton NW (1935) Hyperthyroidism in the aged. Ann Surg 101:1187

    Article  Google Scholar 

  • Connolly RJ, Vidor GI, Stewart JC (1970) Increase in thyrotoxicosis in endemic goiter area after iodination of bread. Lancet 1:500

    Article  PubMed  CAS  Google Scholar 

  • Cookson H (1939) Toxic goiter with special reference to the disease in older people. Lancet 1:1363

    Article  Google Scholar 

  • Cope O, Rowson RW, McArthur JW (1947) The hyperfunctioning single adenoma of the thyroid. Surg Gynecol Obstet 84:415

    PubMed  CAS  Google Scholar 

  • Crile G (1938) Hyperthyroidism in the extremes of life. Cleve Clin 5:117

    Google Scholar 

  • Cropper CFJ (1973) Hypothyroidism in psychogeriatric patients - Ankle Jerk reaction time as a screening technique. Gerontol Clin 15:15

    Article  CAS  Google Scholar 

  • Dailey ME, Skahan JR (1956) A statistical appraisal of the serum protein bound iodine as a test of thyroid function. N Engl J Med 254:907

    Article  PubMed  CAS  Google Scholar 

  • Davis PJ (1966) Factors affecting the determination of the serum protein-bound-iodine. Am J Med 40:918

    Article  PubMed  CAS  Google Scholar 

  • Davis PJ, Davis FG (1974) Hyperthyroidism in patients over the age of 60 years. Clinical feature in 85 patients. Medicine (Baltimore) 53:161

    CAS  Google Scholar 

  • De Gênnes, Batrinos MC, Moreau L, Deschamps H (1961) L’hyperthyroidie du sujet âgé de plus de 60 ans. Presse Méd 69:2425

    PubMed  Google Scholar 

  • Dewind LT, Commons RR, Starr P (1958) Diagnosis and management of hyperthyroidism in the aged. Geriatrics 13:67

    PubMed  CAS  Google Scholar 

  • Döpke G (1964) Die Hyperthyreose im höheren Lebensjahr. Wien Klin Wochenschr 76:613

    Google Scholar 

  • Dogliotti GC, Nizzi NG (1935) Thyroid and senescence: structural transformations of the thyroid in old age and their functional interpretation. Endocrinology 19:285

    Article  Google Scholar 

  • Dow EC, Lerman J (1965) Myxedema: coma and complications. N Y Acad Press 1200

    Google Scholar 

  • Droese M (1979) Methodische Gesichtspunkte und Treffsicherheit der Feinnadelpunktion der Schilddrüse. Nuklearmediziner 2:111

    Google Scholar 

  • Einhorn J, Wicklund H (1966) Hypothyroidism following 131 J treatment for hyperthyroidism. J Clin Endocrinol Metab 26:33

    Article  PubMed  CAS  Google Scholar 

  • Engler D, Donaldson EB, Stockigt JR, Taft P (1978) Hyperthyroidism without trijod-thyronine excess. An effect of severe non-thyroidal illness. J Clin Endocrinol Metab 46:77

    Article  PubMed  CAS  Google Scholar 

  • Evered D, Hall R (1972) Hypothyroidism. Br Med J 1:290

    Article  PubMed  CAS  Google Scholar 

  • Evered DC, Turnbridge WMG, Hall R, Appleton D, Brewis M, Clark F, Manuel P, Young E (1978) Thyroid hormone concentrations in a large scale community survey, effect of age, sex, illness, and medication. Clin Chim Acta 83:223

    Article  PubMed  CAS  Google Scholar 

  • Fowler PBS (1972) Premyxoedema: a cause of preventable coronary heart disease. Proc R Soc Med 70:297

    Google Scholar 

  • Frolkis YV, Verzhikovskaya NV, Valueva GV (1973) The thyroid and age. Exp Gerontol 8:285

    Article  PubMed  CAS  Google Scholar 

  • Gaffney GW, Gregerman R, Yiengst MJ, Shock NW (1960) Serum protein bound iodine concentrations in blood of euthyroid men aged 18 to 94 year. J Gerontol 15:234

    PubMed  CAS  Google Scholar 

  • Gaffney GW, Gregerman R, Shock NW (1973) Relationship of age to the thyroidal accumulation, renal excretion, and distribution of radioiodide in euthyroid man. J Clin Endocrinol Metab 22:784

    Article  Google Scholar 

  • Gatti A, Pozzi G (1975) Thyroid pathology in the elderly. J Gerontol 23:377

    Google Scholar 

  • Geiser J, Bürgi H, Grob PJ, Studer H (1978) Bedeutung der Schilddrüsenkrankheiten in einer allgemeininternistischen Klinik. Schweiz Med Wochenschr 108:1152

    PubMed  CAS  Google Scholar 

  • Gemsenjäger E, Staub JJ, Girard PH, Heitz J (1976) Preclinical hyperthyroidism in multinodular goiter. J Clin Endocrinol Metab 43:810

    Article  PubMed  Google Scholar 

  • Goldberg M, Larson FC (1963) The achilles reflex. Diagnostic test of thyroid dysfunction. Lancet 1:243

    PubMed  Google Scholar 

  • Golden AW, Russel Fraser T (1969) Treatment of thyrotoxicosis with low doses of radioactive iodine. Br Med J 3:442

    Article  Google Scholar 

  • Grad B (1969) The metabolic responsiveness of young and old female rats to thyroxine. J Gerontol 24:5

    PubMed  CAS  Google Scholar 

  • Grad B, Hoffmann MM (1955) Thyroxine secretion rates and plasma cholesterol levels of young and old rats. Am J Physiol 182:497

    PubMed  CAS  Google Scholar 

  • Greene AM, Hurxthall LM (1941) A postoperative follow-up-study of 469 thyrocardiac patients. N Engl J Med 225:811

    Article  Google Scholar 

  • Gregerman RJ (1976) The age related alteration of thyroid function and thyroid hormone metabolism in man. Endocrines and aging, Symp. Gerontological Soc. Am Lect Ser 662:161

    Google Scholar 

  • Gregerman RI, Gaffney GW, Shock NW, Crowder SE (1962) Thyroxine turnover in euthyroid man with special reference to changes with age. J Clin Invest 41:2065

    Article  PubMed  CAS  Google Scholar 

  • Guinet P, Bory RM (1973) L’hyperthyroidie chez le sujet de plus de 65 ans. Probl Acta En-docr Nutr 17:73

    Google Scholar 

  • Gurney C, Owen SG, Hall R, Roth M, Harper M, Smart GA (1970) Newcastle thyrotoxicosis index. Lancet 2:1275

    Article  PubMed  CAS  Google Scholar 

  • Hagen GA, Ouellette RP, Chapman EM (1967) Comparison of high and low dosage levels of 131 J in the treatment of thyrotoxicosis. N Engl J Med 276:559

    Article  Google Scholar 

  • Hansen JM, Skovsted L, Siersbaek-Nielsen K (1975) Age dependent changes in iodine metabolism and thyroid function. Acta Endocrinol (Kbh) 79:60

    CAS  Google Scholar 

  • Harris JA, Bendekit FG (1919) A biometric study of basal metabolism in man. Carnegie Inst Wash Publ 279

    Google Scholar 

  • Harvey RF (1971) Indices of thyroid function in thyrotoxicosis. Lancet 2:230

    Article  PubMed  CAS  Google Scholar 

  • Hausmann W (1970) Myxoedema crisis. Hormones 1:110

    Article  PubMed  CAS  Google Scholar 

  • Hay I (1936) The thyrotoxic heart with special references to masked hyperthyroidism. Lancet 2:1377

    Article  Google Scholar 

  • Helsloot MH (1976) Hyperthyreoidie op oudere leeftijd. Tijdschr Ziekenverpl 29:20, 944

    PubMed  CAS  Google Scholar 

  • Helsloot MH, Der Kinderen PJ, Sander PC (1976 a) Hyperthyreoidie op oudere leetftijd. I. het klinische beeid. Ned t Geneeskd 120:2, 47

    CAS  Google Scholar 

  • Helsloot MH, Der Kinderen PJ, Sander PC (1976 b) Hyperthyreoidie op oudere leetftijd. II. Laboratoriumsoderzoek. Ned Tijdschr Geneeskd 120:3, 87

    PubMed  CAS  Google Scholar 

  • Hengst K, Wagner H, Gerlach U (1980) Zur Diagnose und Therapie von Hyperthyreose und Hypothyreose im höheren Lebensalter. Tempo Med 19:20

    Google Scholar 

  • Henschke PJ, Pain RW (1977) Thyroid disease in a psychogeriatric population. Age Ageing 6:151

    Article  PubMed  CAS  Google Scholar 

  • Herrmann J, Heinen E, Kröll HJ, Rudorff KH, Krüskemper HL (1981) Thyroid function and thyroid hormone metabolism in elderly people. Low T3-syndrome in old age? Klin Wochenschr 59:315

    Article  PubMed  CAS  Google Scholar 

  • Herrmann J, Rusche J, Kröll HJ, Hilger P, Krüskemper HL (1974 a) Free trijodthyronine (T3) and thyroxine (T4) serum levels in old age. Horm Metab Res 6:239

    Article  PubMed  CAS  Google Scholar 

  • Herrmann J, Eickenbusch W, Emrich D, Köbberling J, Rudorff KH, Höfner M, Junge-Hül-sing G, Kirschsieper H, Mühlen Avz, Otto H, Nicklas L, Pickardt R, Schleusener H, Dicht R, Hengst K, Wagner H, Wuttke H (1981) Prevelance of hypothyroidism in the elderly in Germany. J Endocrinol Invest 4:327

    PubMed  CAS  Google Scholar 

  • Herrmann J, Rusche HJ, Kröll HJ, Rudorff KH, Krüskemper HL (1974 b) Trijodthyronin: Abnahme der Serumkonzentration mit zunehmendem Alter. Dtsch Med Wochenschr 99:2122

    PubMed  CAS  Google Scholar 

  • Hesch RD, Gatz J, Pope J, Schmidt E, Mühlen Avz (1976) Total and free trijodthyronine and thyroid binding globuline concentrations in elderly human persons. Eur J Clin Invest 6:139

    Article  PubMed  CAS  Google Scholar 

  • Hoenle R (1980) Mehr diagnostische Sicherheit in der Ausschlußdiagnostik der Hyperthyreose durch den TRH-Stimulationstest mit Thyroliberin. Therapiewoche 30:7181

    Google Scholar 

  • Hollis WC (1968) The aged thyroid gland. Geriatrics 23:124

    PubMed  CAS  Google Scholar 

  • Holvey DN, Goodner CJ, Nocoloff JT (1964) Treatment of myxedema coma with intravenous thyroxine. Arch Intern Med 113:89

    PubMed  CAS  Google Scholar 

  • Horst WH, Rosier H, Schneider H, Labhart A (1967) 306 cases of toxic adenoma: clinical aspects, finding in radioiodine diagnostics, radiochromatography, and histology, results of 131 I and surgical treatment. J Nucl Med 8:515

    PubMed  CAS  Google Scholar 

  • Hossdorf Th, Gelis Th, Lueg R, Vosberg H, Wagner H (1980) Altersbedingte Veränderungen der peripheren Schilddrüsenparameter, ihre hypophysäre Regulation sowie Beziehung zum Fettstoffwechsel. Z Gerontol 13:7

    Google Scholar 

  • Ingbar SH (1978) The influence of ageing on the human thyroid hormone economy. Geriatr Endocrinol (Aging) 5:13

    CAS  Google Scholar 

  • Iversen K ((1953) Thyrotoxicoses in aged individuals. J Gerontol 8:65

    PubMed  CAS  Google Scholar 

  • Ivy HK (1965) Myxedema precoma: complications and therapy. Majo Clin Proc 40:403

    CAS  Google Scholar 

  • Jeffreys PM, Farran HEA, Hoffenberg R, Fraser PM, Hodkinson HM (1972) Thyroid function tests in the elderly. Lancet 1:924

    Article  Google Scholar 

  • Joseph K, Mahlstedt J, Welcke U (1979 a) Thyreoidale Autonomie-Altersverteilung und Verhalten unter Jodprophylaxebedingungen. Nucl Compact 100

    Google Scholar 

  • Joseph K, Mahlstedt J, Gonnermann R, Herbert K, Weilcke U (1979 b) Verlaufsuntersuchungen bei Patienten mit autonomem Schilddrüsengewebe. Nucl Compact 206

    Google Scholar 

  • Keys A, Taylor HL, Grande F (1973) Basal metabolism and age of adult man. Metabolism 22:579

    Article  PubMed  CAS  Google Scholar 

  • Kirkegaard C, Siersbaek-Nielsen K, Friis Th, Rogowski P (1975) Does T 4 Toxicosis exist? Lancet 1:868

    Article  PubMed  CAS  Google Scholar 

  • Klein E (1960) Der endogene Jodhaushalt des Menschen und seine Störungen. Georg Thie-me Verlag, Stuttgart

    Google Scholar 

  • Kloeppel FC (1910) Vergleichende Untersuchungen über Gebirgsland- und Tieflandschilddrüsen. Beiträge Path Anat 49:588

    Google Scholar 

  • Köbberling J, Hintze G, Dirks H, Emrich D (1980) Spezifische Probleme der Hyperthyreose im höheren Lebensalter. In: Verh. d. dtsch. Sektion Schilddrüse, S 55

    Google Scholar 

  • Korenchensky V, Paris SK, Benjamin B (1953) Treatment of senescene in male rats with sex and thyroid hormones and desoxycorticosterine acetate. J Gerontol 8:4, 415

    Google Scholar 

  • Kountz WB, Chieffi M, Kirk JF (1949) Serum-protein-bound iodine and age. J Gerontol 4:132

    PubMed  CAS  Google Scholar 

  • Lahey FH (1931) Non-activated (apathetic) type of hyperthyroidsm. Engl J Med 204:747

    Article  Google Scholar 

  • Larsen PR (1972) Trijodthyronine: Review of recent studies of its physiology and pathophysiology in man. Metabolism 21:1073

    Article  PubMed  CAS  Google Scholar 

  • Lazarus JH, Harden RM (1969) Thyrotoxicosis in the elderly. Gerontol Clin 11:371

    Article  CAS  Google Scholar 

  • Lemarchand Beraud, Vaenoth A (1969) Relationship between blood thyrotropin level, protein bound iodine and free thyroxine concentration in man under normal physiological conditions. Acta Endocrinol (Kbh) 60:315

    Google Scholar 

  • Levine SA, Sturges CC (1924) Hyperthyroidism masked as heart disease. Boston Med Soc J 233

    Google Scholar 

  • Littmann DS, Jeffers WA, Rose E (1957) The infrequency of myocardial infarction in patients with thyrotoxicosis. Am J Med Sci 233:10

    Article  Google Scholar 

  • Lloyd WH, Goldberg IJL (1961) Incidence of hypothyroidism in the elderly. Br Med J 2:1256

    Article  PubMed  CAS  Google Scholar 

  • Löwenhagen P, Sprenger E (1974) Cytologic presentation of thyroid tumors in aspiration biopsy smears. Acta Cytol (Baltimore) 18:192

    Google Scholar 

  • Markson JC, Flatman GE (1965) Myxedema after deep x-ray therapy to the neck. Br Med J 1:1228

    Article  PubMed  CAS  Google Scholar 

  • McConahey WM (1978) Diagnosing and treating myxedema and myxedema coma. Geriatrics 3:61

    Google Scholar 

  • McGavack Th, Seegers W (1959) Status of the thyroid gland after the age of 50. Metabolism 8:136

    PubMed  CAS  Google Scholar 

  • McGee RR, Whittaker RL, Tullis IF (1959) Apathetic thyroidism: Review of the literature and report of four cases. Ann Intern Med 50:1418

    PubMed  CAS  Google Scholar 

  • McMillan TM, Wendlos M (1937) Some of the typical manifestations of hyperthyroidism which obscure its diagnosis with observations on some of the cardiac features of this condition. Int Clin 3:213

    Google Scholar 

  • Menendez CE, Rivlin RS (1973) Thyrotoxic crisis and myxedema coma. Med Clin North Am 57:1463

    PubMed  CAS  Google Scholar 

  • Moholm Hansen J (1978) Age dependent changes in iodine metabolism and thyroid function. Acta Endocrinol (Kbh) 79:223

    Google Scholar 

  • Moreau L (1966) L’hyperthyreoidie chez le sujet de plus de 60 ans. Clinique LXI (615):25

    Google Scholar 

  • Morrow LB (1978) How thyroid disease presents in the elderly. Geriatrics 33:42

    PubMed  CAS  Google Scholar 

  • Müller HA (1980) Die Feinnadelpunktion der Schilddrüse aus der Sicht des Zytologen. Nuklearmediziner 3:261

    Google Scholar 

  • Narrang GD, Turner LW (1966) Effect of advancing age on thyroid hormone secretion rate of female rats. Proc Soc f Exp Biol and Med 121:203

    Google Scholar 

  • Nofal MM, Beierwaltes WH, Patno ME (1966) Treatment of hyperthyroidism with sodium jodide J 131. JAMA 197:8, 87

    Article  Google Scholar 

  • Oberdisse K (1980) Die Hyperthyreose. In: Oberdisse K, Klein E, Reinwein D (eds) Die Krankheiten der Schilddrüse. Georg Thieme Verlag, Stuttgart New York

    Google Scholar 

  • Oddie Th, Fisher D (1965) Protein bound iodine level during childhood and adolescence. J Clin Endocrinol Metab 28:89

    Google Scholar 

  • Oddie Th, Myhill J, Pirnique FG, Fisher DM (1968) Effect of age and sex on radioiodine uptake in euthyroid subjects. J Clin Endocrinol Metab 28:776

    Article  PubMed  CAS  Google Scholar 

  • Ohara HT, Kobayansky T, Shiraishi M, Wada T (1974) Thyroid function of the aged as viewed from pituitary thyroid system. Endocrinol Jpn 21:377

    Article  PubMed  CAS  Google Scholar 

  • Olsen T, Laurberg P, Weeke J (1978) Low serum triiodthyronine and high serum reverse triiodthyronine in old age. J Clin Endocrinol Metab 47:1111

    Article  PubMed  CAS  Google Scholar 

  • Ormston BJ, Kilborn JR, Garry R, Anos J, Hall R (1971) Further observation on the effect of synthetic thyrotropin releasing hormone in man. Br Med J 2:199

    Article  PubMed  CAS  Google Scholar 

  • Owen GG, Smart GA (1958) Thyroid antibodies in myxoedema. Lancet 2:1034

    Article  PubMed  CAS  Google Scholar 

  • Perlmutter M, Riggs DS (1953) Thyroid collections of radioactive jodine in plasma or serum. Am J Clin Pathol 23:493

    Google Scholar 

  • Perry WF, Cosgrove JBR (1949) Protein Bound iodine as an aid to the diagnosis of thyroid disease. Can Med Assoc J 60:602

    PubMed  CAS  Google Scholar 

  • Petersen F (1978) Altersabhängige Änderungen im Regelkreis Schilddrüse. Therapiewoche 28:961

    CAS  Google Scholar 

  • Pickardt CR, Bauer M, Horn K, Kubiczek Th, Scriba PC (1977) Vorteile der direkten Bestimmung des Thyroxin-bindenden Globulins (TBG) in der Schilddrüsendiagnostik. Internist 18:538

    PubMed  CAS  Google Scholar 

  • Pickardt CR, Gärtner R, Habermann J, Horn K, Scriba PC, Horster FA, Wagner H, Hengst K (1981) Therapie der blanden Struma. Dtsch Med Wochenschr 106:18, 579

    Article  PubMed  CAS  Google Scholar 

  • Pottnay HE, O’Brian IT, Bush J, Vagenakis AG, Azini F, Ingbar SH, Bravermann LE (1974) The effect of starvation on the concentration and binding of thyroxine and tri-jodthyronine in serum and on the response to TRH. J Clin Endocrinol Metab 39:199

    Article  Google Scholar 

  • Quimby EH, Werner SC, Schmidt C (1950) Influence of age, sex, and season upon radioiodine uptake by the human thyroid. Proc Soc Exp Biol Med 75:537

    PubMed  CAS  Google Scholar 

  • Reed AH, Cannon DC, Winkelmann JW, Bhasin YP, Henry RJ, Pileggi VJ ((1972) Estimation of normal ranges from a controlled sample group: I. Sex and age related influence on the SMA-12–60-screening group of tests. Clin Chem 18:57

    PubMed  CAS  Google Scholar 

  • Reiners Ch, Börner W (1980) Zur Diagnose und Verlaufskontrolle des Schilddrüsenmali-gnoms. Nuklearmediziner 3:193

    Google Scholar 

  • Ries N, Allegretti N (1965) Number and size of thyroid follicles in guinea pigs of different age. Endocrinology 76:329

    Article  PubMed  CAS  Google Scholar 

  • Rössle R, Roulet F (1932) Maß und Zahl in der Pathologie. Springer-Verlag, Berlin

    Google Scholar 

  • Ronnøv-Jessen VC, Kirkegaard C (1973) Hyperthyroidism - a disease of old age? Br Med J 1:41

    Article  PubMed  Google Scholar 

  • Rosenberg JN (1968) Hypothermia and coma. Surg Clin North Am 48:353

    PubMed  CAS  Google Scholar 

  • Rubenstein HA, Butler VP, Werner SC (1973) Progressive decrease in serum trijodthyronine concentrations with human aging. Radioimmunoassay following extraction of serum. J Clin Endocrinol Metab 37:247

    Article  PubMed  CAS  Google Scholar 

  • Rudorff KH, Herrmann J, Kröll HJ, Rusche HJ, Krüskemper HL (1972) T4/T3-turnover- kinetics, TRH and TSH-tests, total and free T4 and T3, TBG and reverse T3-concen- trations in healthy and sick old subjects. Acta Endocrinol (Kbh), Suppl 204:82

    Google Scholar 

  • Rudorff KH, Herrmann J, Krüskemper HL (1977) Thyroxine binding globulin (TBG) in serum: comparison of radioimmunoassay (RIA) with competitive ligand binding assay (CLBA). Endocrinol 38:10 A

    Google Scholar 

  • Rudorff KH, Herrmann J, Krüskemper HL (1981) Altersabhängige Änderungen von In-vitro-Parametern für die Schilddrüsendiagnostik. Intern Welt 3:102

    Google Scholar 

  • Sagild U (1956) Total exchangable potassium in normal subjects with special references to changes with age. Scand J Clin Lab Invest 8:44

    Article  PubMed  CAS  Google Scholar 

  • San Marco JL, Paulin R, Simonin R (1972) Cinétique de la T 3 et de la T 4 chez le vieillard. Taux de production. Endocrinol Ann. (Paris) 34:391

    Google Scholar 

  • Savage GH (1880) Myxoedema and its nervous symptoms. J Ment Sci 25:517

    Google Scholar 

  • Scazziga BR, Barbieri LL, Beraud T (1955) La fonction thyreoidienne chez le vieillard. Schweiz Med Wochenschr 85:393

    PubMed  CAS  Google Scholar 

  • Schauer A, Kunze E, Matzner B (1972) Pseudocarcinomatöse Schilddrüsenveränderungen nach Thyreostatika-Therapie. Verh Dtsch Ges Pathol 56:369

    PubMed  CAS  Google Scholar 

  • Scheinberg P, Stead EA, Brannon ES, Warren JV (1964) Correlative oberservations on cerebral metabolism and cardiac output in myxedema. J Clin Invest Sci 248:399

    Google Scholar 

  • Schneeberg NG (1964) The treatment of myxedema with sodium dextrothyroxine. Am J Med Sci 248:399

    Article  PubMed  CAS  Google Scholar 

  • Schultz AL (1978) Diagnosing and managing hyperthyroidism. Geriatrics 33:71

    Google Scholar 

  • Seed L, Lindsay AM (1949) Hyperthyroidism in the aged. Geriatrics 4:136

    PubMed  CAS  Google Scholar 

  • Shafer RB, Nutall FQ (1975) Acute changes in thyroid function in patients treated with radioactive iodine. Lancet 2:63

    Google Scholar 

  • Shock NW (1955) Metabolism and age. J Chron Dis 2:687

    Article  PubMed  CAS  Google Scholar 

  • Shock NW, Yiengst M (1952) Basal oxygen consumption and basal respiratory function in aged males. Presented before the 5 th Annular Scientific Meeting, Gerontological Society Inc. Washington D.C. J Gerontol 7:495

    Google Scholar 

  • Shock JM, Surks MI, Oppenheimer JH (1974) Replacement dosage of 1-thyroxine in hypothyroidism. A reevaluation. N Engl J Med 290:529

    Article  Google Scholar 

  • Silver S (1962) Radioactive isotopes in medicine and biology. Medicine 2

    Google Scholar 

  • Snyder PJ, Utiger RD (1972) Response to thyrotropin releasing hormone (TRH) in normal man. J Clin Endocrinol Metab 34:380

    Article  PubMed  CAS  Google Scholar 

  • Sotomayer LL, Bowers CGB (1964) Myxedema coma. Springfield CC, Ed Thomas

    Google Scholar 

  • Starr P (1960) The therapeutic value of sodium dextrothyroxine. Clin Pharmacol Ther 1:716

    Google Scholar 

  • Stiel JN, Hales IB, Rieve TS (1972) Thyrotoxicosis in an elderly population. Med J Aust 2:986

    PubMed  CAS  Google Scholar 

  • Studer H, Bürgi H, König MP (1978) Die klinische Bedeutung der „sub- oder praeklini-schen“ Hyperthyreose. Schweiz Med Wochenschr 108:2029

    PubMed  CAS  Google Scholar 

  • Thomas FB, Mazzaferri EL, Skillman Th (1970) Apathetic thyrotoxicosis: a distinctive clinical and laboratory entitiy. Ann Intern Med 72:679

    PubMed  CAS  Google Scholar 

  • Tonks CM (1964) Mental illness in hypothyroid patients. Br J Psychiat 110:706

    Article  CAS  Google Scholar 

  • Trotter WR (1965) A proposed method for the prevention of hypothyroidism following J 131 treatment of thyrotoxicosis. In: Current topics in thyroid research. Proc. 5th Intern Thyroid Conf. Academic Press, p 1159

    Google Scholar 

  • Tucker RG, Keys A (1951) Concentrations of serum protein bound iodine in normal man. J Clin Invest 30:869

    Article  PubMed  CAS  Google Scholar 

  • Turner JG, Brownlie BEW, Sadler WA (1975) Does T 4 toxicosis exist? Lancet 1:407

    Article  PubMed  CAS  Google Scholar 

  • Vanhaelst L, Neeve P, Chailly P, Bastenie PA (1967) Coronary artery disease in hypothyroidism. Lancet 2:800

    Article  PubMed  CAS  Google Scholar 

  • Verzar F, Freydberg V (1956) Changes of thyroid activity in the rat in old age. J Gerontol 11:53

    PubMed  CAS  Google Scholar 

  • Vosberg H, Wagner H, Böckel K, Hauss WH (1976) Altersabhängige Veränderungen der Hypophysen-Schilddrüsenregulation. Acta Gerontol 6:279

    CAS  Google Scholar 

  • Wagner H, Vosberg H, Böckel K, Hrubesch M, Grote G, Hauss WH (1974) Influence of age on response of TSH to thyrotropin releasing hormone in normal subjects. Acta Endocrinol (Kbh), Suppl 184:119

    Google Scholar 

  • Wagner H, Vosberg H, Grote G, Böckel K, Hrubesch M, Hauss WH (1975) Altersabhängige Abnahme der Stimulierbarkeit der TSH-Sekretion durch Thyrotropin-Releasing-Hormon bei Männern und Frauen. Z Gerontol 8:38

    Google Scholar 

  • Wagner H, Hossdorf Th, Hengst K (1977) Schilddrüsenfunktionsdiagnostik. Münch Med Wochenschr 119:983

    CAS  Google Scholar 

  • Wagner H, Hossdorf Th, Vosberg H (1979) Praktische Bedeutung von altersabhängigen Änderungen der in vitro Meßwerte zur Schilddrüsendiagnostik. Intern Welt 8:285

    Google Scholar 

  • Wayne EJ, Koutras PA, Alexander UD (1964) Clinical aspects of iodine metabolism. Black- well, Oxford

    Google Scholar 

  • Wegelin C (1926) Schilddrüse. In: Drüsen der Inn. Sekretion. Hdb. d. pathol. Anat. VIII. Springer Verlag, Berlin

    Google Scholar 

  • Weissel M, Fritsche H, Stummvoll HK, Kolbe H, Wolf A, Seyfried K (1978) Das Verhalten von Schilddrüsenhormonkonzentrationen im Serum von Patienten mit schweren nicht-thyroidalen Erkrankungen. Wien Klin Wochenschr 90:254

    PubMed  CAS  Google Scholar 

  • Wenzel KH, Horn WR (1975) Trijodthyronine (T 3) and thyroxine (T 4) kinetics in aged man. Excerpta Medica, Intern. Congress Series 361:89

    Google Scholar 

  • Wenzel KW, Meinhold H, Herpich M, Adlkofer F, Schleusener H (1974) TRH-Stimulati- onstest mit alters- und geschlechtsabhängigem TSH-Anstieg bei Normalpersonen. Klin Wochenschr 52:721

    Article  Google Scholar 

  • Werner SC (1962) The thyroid. 2nd Ed. Harper & Row, New York

    Google Scholar 

  • West CF, Chavré VJ (1964) A specific method for the measurement of thyroxine in serum. Proc. 46 th Meeting Endocr. Soc. (USA) 162

    Google Scholar 

  • Westgren U, Burger A, Ingemannson S, Melander A, Tibblin S, Wahlin E (1976) Blood levels of 3´,5,3´ Trijodthyronine and Thyroxine: Differences between children, adults, and elderly subjects. Acta Med Scand 200:493

    Article  PubMed  CAS  Google Scholar 

  • Wishaw R (1946) Toxic goiter in the middle aged and elderly. Med J Aust 2:519

    Google Scholar 

  • Woolner LB (1971) Thyroid carcinoma, pathologic classification with data on prognosis. Sem Nucl Med 1:481

    Article  CAS  Google Scholar 

  • Young Th O (1941) The surgical treatment of thyrotoxicosis as related to geriatrics. West J Surg Obstet Gynec 49:431

    Google Scholar 

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Wagner, H., Hengst, K., Hossdorf, T. (1983). The Aged Thyroid Gland. In: Platt, D. (eds) Geriatrics 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68217-9_5

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