Abstract
Various barbiturates (thiopental, methohexital, pentobarbital, and phenobarbital) are able to ameliorate the adverse effects of complete or incomplete cerebral ischemia. It has been suggested that the neuronal damage which occurs during ischemia is at least partly due to lipid peroxidation and that the barbiturates protect by acting as free radical scavengers. We tested this hypothesis by adding various barbiturates to brain homogenates in which lipid peroxidation was induced by iron and ascorbic acid. We found that thiopental (1 mM) produced only 8% inhibition, while pentobarbital (1 mM) completely inhibited lipid peroxidation. However, methohexital (1 mM) and phenobarbital (1 mM) had no effect. In contrast promethazine, a classical free radical scavenger, produced complete inhibition of lipid peroxidation at a concentration of 0.1 mM.
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© 1981 Springer-Verlag Berlin Heidelberg
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Smith, D.S., St. Rehncrona, Siesjö, B.K. (1981). Effects of Barbiturates and of Promethazine on Lipid Peroxidation in Brain Tissue. In: Haid, B.C., Mitterschiffthaler, G. (eds) Zentraleuropäischer Anaesthesiekongreß. Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine, vol 141. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68190-5_11
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DOI: https://doi.org/10.1007/978-3-642-68190-5_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-10944-0
Online ISBN: 978-3-642-68190-5
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