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Bioavailability of Cardiac Glycosides

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Book cover Cardiac Glycosides

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 56 / 2))

Abstract

The concept of bioavailability of drugs was developed by pharmacists. They introduced it to reflect the fact that the way in which a drug is formulated can determine its absorption and therefore the onset and magnitude of its action. To define a drug formulation’s bioavailability is to define both the rate and the extent of that drug’s entry into the circulation and tissues of the body from the site of administration. In brief, it describes how fast and how fully the drug gets to the tissues. Bioavailability is determined by the drug’s chemical characteristics, by the method of formulation and also by physiological factors acting on the administration route. It can be calculated from blood levels of the drug or from the amounts excreted in the urine. The techniques are described below.

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  1. T. R. D. Shaw
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  1. Instituts für Pharmakologie, Universität Düsseldorf, Moorenstraße 5, D-4000, Düsseldorf, Deutschland

    Kurt Greeff (Direktor) (Direktor)

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© 1981 Springer-Verlag Berlin Heidelberg

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Shaw, T.R.D. (1981). Bioavailability of Cardiac Glycosides. In: Greeff, K. (eds) Cardiac Glycosides. Handbook of Experimental Pharmacology, vol 56 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68166-0_8

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  • DOI: https://doi.org/10.1007/978-3-642-68166-0_8

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