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Rubidium Uptake in Erythrocytes

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Cardiac Glycosides

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 56 / 1))

Abstract

Active uptake by „Kälteerythrocyten“ (i.e., human erythrocytes stored at 4 °C for 5–8 days) of photometrically measured potassium has been demonstrated to be inhibited by the cardiac glycosides (c.g.), k-strophanthoside, and digitoxin and their aglucons (Schatzmann, 1953). The drug concentrations necessary to yield this effect ranged from 0.1 µg/ml to 10µg/ml. This effect was shown to be due to an inhibition of membrane Na+-K+-ATPase activity (Post et al., 1960; Dunham and Glynn, 1961; Glynn, 1957).

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Authors
  1. G. G. Belz
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Editors and Affiliations

  1. Instituts für Pharmakologie, Universität Düsseldorf, Moorenstrasse 5, D-4000, Düsseldorf, Germany

    Kurt Greeff (Direktor) (Direktor)

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© 1981 Springer-Verlag Berlin Heidelberg

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Belz, G.G. (1981). Rubidium Uptake in Erythrocytes. In: Greeff, K. (eds) Cardiac Glycosides. Handbook of Experimental Pharmacology, vol 56 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68163-9_7

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  • DOI: https://doi.org/10.1007/978-3-642-68163-9_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68165-3

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