T-Cell-Mediated Immunopathology in Antigen-Induced Arthritis in Mice
Specific immune responses to a wide variety of antigens are under genetic control and many of these are linked to the species major histocompatibility complex (MHC) in the mouse, the rat and man . Moreover, associations between histocompatibility type and susceptibility to disease have been observed in animals and man. Antigen-induced arthritis as a model of rheumatic inflammation was established in the mouse to define the role of humoral and cell-mediated immunity in the induction and persistence of dis ease and to investigate genetic aspects of susceptibility and resistance.
KeywordsMajor Histocompatibility Complex Delay Type Hypersensitivity Delay Type Hypersensitivity Responsiveness Lymphocytic Choriomeningitis Delay Type Hypersensitivity Response
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