T-Cell-Mediated Immunopathology in Antigen-Induced Arthritis in Mice
Specific immune responses to a wide variety of antigens are under genetic control and many of these are linked to the species major histocompatibility complex (MHC) in the mouse, the rat and man . Moreover, associations between histocompatibility type and susceptibility to disease have been observed in animals and man. Antigen-induced arthritis as a model of rheumatic inflammation was established in the mouse to define the role of humoral and cell-mediated immunity in the induction and persistence of dis ease and to investigate genetic aspects of susceptibility and resistance.
KeywordsArthritis Albumin Synovitis
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