Arthritis pp 234-238 | Cite as

T-Cell-Mediated Immunopathology in Antigen-Induced Arthritis in Mice

  • D. Brackertz
  • G. F. Mitchel
  • M. Vadas
  • I. R. Mackay
  • J. A. F. P. Miller
Conference paper

Abstract

Specific immune responses to a wide variety of antigens are under genetic control and many of these are linked to the species major histocompatibility complex (MHC) in the mouse, the rat and man [1]. Moreover, associations between histocompatibility type and susceptibility to disease have been observed in animals and man. Antigen-induced arthritis as a model of rheumatic inflammation was established in the mouse to define the role of humoral and cell-mediated immunity in the induction and persistence of dis ease and to investigate genetic aspects of susceptibility and resistance.

Keywords

Arthritis Albumin Synovitis 

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References

  1. 1.
    Fischer RA (ed) Statistical Methods for Research Workers. Oliver Boyd, Edinburgh London, p 99Google Scholar
  2. 2.
    Vadas MA, Miller JAFP, Gamble J, Whitelaw A (1975) Int Arch Allergy Appl Immunol 49:679CrossRefGoogle Scholar
  3. 3.
    Lamoureux GPR, Carnegie PR, McPherson TA, Mackay IR, Bernard G (1978) Ann Inst Pasteur 118:562Google Scholar
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    Hotchin J (1971) Monogr Virol 3:1Google Scholar
  5. 5.
    Brackertz D, Mitchell GF, Vadas MA, Mackay IR, Miller JAFP (1977) J Immunol 118:1639PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • D. Brackertz
  • G. F. Mitchel
  • M. Vadas
  • I. R. Mackay
  • J. A. F. P. Miller

There are no affiliations available

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