Skip to main content

Lymphocyte Populations and Subpopulations in Rheumatoid Arthritis

  • Conference paper
Book cover Arthritis
  • 77 Accesses

Abstract

It represented a major breakthrough in studies of immunologic mechanisms of disease when it became possible to identify and quantify human lymphocyte populations with the various surface markers discovered during the last 10 years [7, 28]. These marker techniques also represented a new approach to the investigation of immunopathogenesis in rheumatoid arthritis, and the first reports on lymphocyte populations in this disease appeared relatively early after the introduction of the surface marker assays. Today the literature on this topic is abundant and somewhat confusing. Before presenting an attempt at a survey of the field, it is necessary to discuss briefly the concepts of surface markers for identification of human lymphocytes in clinical disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abo T, Yamaguchi T, Shimizu F, Kumagai K (1976) Studies of surface immunoglobulins on human B lymphocytes. II. Characterisation of a population of lymphocytes lacking surface immunoglobulins but carrying Fc receptors (SIg-Fc+ cell). J Immunol 117:1781–1787

    PubMed  CAS  Google Scholar 

  2. Abrahamsen TG, Fröland SS, Natvig JB (1975) Elution and characterisation of lymphocytes from rheumatoid inflammatory tissue. Scand J Immunol 4: 823–830

    PubMed  CAS  Google Scholar 

  3. Abrahamsen TG, Fröland SS, Natvig JB, Pahle J (1976) Antigen and unspecific mitogen stimulation of lymphocytes eluted from rheumatoid inflammatory tissue. Scand J Immunol 5:1057–1063

    Article  PubMed  CAS  Google Scholar 

  4. Abrahamsen TG, Fröland SS, Natvig JB, Pahle J (1977) Lymphocytes eluted from synovial tissue of juvenile rheumatoid arthritis patients. Arthritis Rheum 20:772–778

    Article  PubMed  CAS  Google Scholar 

  5. Abrahamsen TG, Fröland SS, Natvig JB, Pahle J (1977) Antibody-dependent cytotoxicity mediated by cells eluted from synovial tissue of patients with rheumatoid arthritis and juvenile rheumatoid arthritis. Scand J Immunol 6:1251–1261

    Article  PubMed  CAS  Google Scholar 

  6. Abramson N, Gelfand EW, Jandl JH, Rosen FS (1970) The interaction between human monocytes and red cells. Specificity for IgG subclasses and IgG fragments. J Exp Med 132:1207–1215

    Article  PubMed  CAS  Google Scholar 

  7. Aiuti T, Cerottini J-C, Coombs RRA, Cooper M, Dickler HB, Fröland SS, Fudenberg HH, Greaves MF, Grey HM, Kunkel HG, Natvig JB, Preud’homme J-J, Rabellino E, Ritts RE, Rowe DS, Seligmann M, Siegal FP, Stjernsvärd J, Terry WD, Wybran J (1974) Special technical report: Identification, enumeration and isolation of B and T lymphocytes from human peripheral blood. Scand J Immunol 3:521–532

    Article  Google Scholar 

  8. Alarcon-Segovia, Ruiz-Arguelles (1980) Suppressor cell loss and dysfunction in mixed connective tissue disease. Arthritis Rheum 23:314–318

    Article  PubMed  CAS  Google Scholar 

  9. Alexander EI, Henkart PA (1978) Human peripheral lymphocytes bearing surface immunoglobulin do not have readily detectable Fc-receptors. Clin Exp Immunol 33:332–338

    PubMed  CAS  Google Scholar 

  10. Bach JF, Delrieu F, Delbarre F (1970) The rheumatoid rosette. A diagnostic test unifying seropositive and seronegative rheumatoid arthritis. Am J Med 49:213–222

    Article  PubMed  CAS  Google Scholar 

  11. Bankhurst AD, Husby G, Williams RC (1976) Predominance of T cells in the lymphocytic infiltrates of synovial tissues in rheumatoid arthritis. Arthritis Rheum 19:555–562

    Article  PubMed  CAS  Google Scholar 

  12. Biberfeld G, Nilsson E, Biberfeld P (1979) T lymphocyte subpopulations in synovial fluid of patients with rheumatic disease. Arthritis Rheum 22:978–982

    Article  PubMed  CAS  Google Scholar 

  13. Biberfeld G, Nilsson E, Stedingk LV von (1980) Helper and suppressor activity in synovial fluid lymphocytes of patients with rheumatic disease (Abstract). 14.7.03, 4th International Congress of Immunology, Paris, July 1980

    Google Scholar 

  14. Bouvet J-P, Dechy H, Guilabert A, Levy R, Dorra M (1978) Le test de rosettes rhumatoides au cours des endocarditis bacteriennes. Un test non specifique d’inflammation. Nouv Presse Med 7:1929–1937

    PubMed  CAS  Google Scholar 

  15. Brenner AI, Scheinberg MA, Cathcart ES (1975) Surface characteristics of synovial fluid and peripheral blood lymphocytes in inflammatory arthritis. Arthritis Rheum 18:297–303

    Article  PubMed  CAS  Google Scholar 

  16. Bull DM, Bookman MA (1977) Isolation and functional characterisation of human intestinal mucosal lymphoid cells. J Clin Invest 59:966–974

    Article  PubMed  CAS  Google Scholar 

  17. Burmester GR, Kalden JR, Peter HH, Schedel L, Beck P, Wittenborg A (1978) Immunological and functional characteristics of peripheral blood and synovial fluid lymphocytes from patients with rheumatoid arthritis. Scand J Immunol 7:405–417

    Article  PubMed  CAS  Google Scholar 

  18. Chattopadhyay C, Chattopadhyay H, Natvig JB, Michaelsen TE, Mellbye OJ (1979) Lack of suppressor cell activity in rheumatoid synovial lymphocytes. Scand J Immunol 10:309–316

    Article  PubMed  CAS  Google Scholar 

  19. Clot J, Andary M, Andress D, Sany J (1980) Subsets and functions of mononuclear cells involved in the regulation of immune responses in rheumatoid arthritis (RA) patients. Abstract 14.7.10, 4th International Congress of Immunology, Paris, July 1980

    Google Scholar 

  20. De Vries E, van Leeuwen AWFM, van de Putte GJM, Meyer CJLM (1977) Atypical T cells in rheumatoid synovial membranes. Virchows Arch (Cell Pathol) 24:19–26

    Google Scholar 

  21. Dickler HB (1976) Lymphocyte receptors for immunoglobulin. Adv Immunol 24:167–214

    Article  PubMed  CAS  Google Scholar 

  22. Dobloug JH, Chattopadhyay C, Førre Ø, Höyeraal HM, Natvig JB (1981) Con A-induced suppressor cell activity and T-lymphocyte subpopulations in peripheral blood lymphocytes of patients with rheumatoid arthritis and juvenile rheumatoid arthritis. Scand J Immunol 13:367–373

    Article  PubMed  CAS  Google Scholar 

  23. Dorwart BB, Hebert J, Schumacher HR, Abdou NI (1975) Cellular and humoral immune parameters of synovial fluid and blood in rheumatoid arhtiris. J Rheumatol 2:363–369

    PubMed  CAS  Google Scholar 

  24. Fauci AS (1980) Immunoregulation in autoimmunity. J Allergy Clin Immunol 66:5–17

    Article  PubMed  CAS  Google Scholar 

  25. Ferrarini M, Cadoni A, Franzi AD, Ghigliotti C, Leprini A, Zicca A, Grossi CE (1980) Ultrastructure and cytochemistry of human peripheral blood lymphocytes. Similarities between the cells of the third population and Tγ lymphocytes. Eur J Immunol 10:562–570

    Article  PubMed  CAS  Google Scholar 

  26. Fröland SS (1979) K cells and related Fc receptor bearing human lymphocytes. Immunological characterisation and possible clinical significance. Folia Allergol Immunol Clin 26:1–9

    Article  Google Scholar 

  27. Fröland SS, Abrahamsen TG (1979) Lymphocyte populations in blood and synovia in rheumatoid arthritis. In: Panayi GS, Johnson P (eds) Immunopathogenesis of rheumatoid arthritis. Reedbooks, London, pp 25–30

    Google Scholar 

  28. Fröland SS, Natvig JB (1973) Identification of three different human lymphocyte populations by surface markers. Transplant Rev 16:114–162

    PubMed  Google Scholar 

  29. Fröland SS, Natvig JB, Husby G (1973) Immunological characterization of lymphocytes in synovial fluid from patients with rheumatoid arthritis. Scand J Immunol 2:67–74

    Article  PubMed  Google Scholar 

  30. Fröland SS, Wislöff F, Michaelsen TE (1974) Human lymphocytes with receptors for IgG. A population of cells distinct from T- and B-lymphocytes. Int Arch Allergy Appl Immunol 47:124–138

    Article  PubMed  Google Scholar 

  31. Fröland SS, Natvig JB, Wislöff F (1975) Lymphocyte subpopulations in rheumatoid arthritis. Rheumatology 6:231–241

    PubMed  Google Scholar 

  32. Frydén A (1977) B and T lymphocytes in blood and cerebrospinal fluid in acute aseptic meningitis. Scand J Immunol 6:1283–1290

    Article  Google Scholar 

  33. Galili U, Rosenthal L, Galili N, Klein E (1979) Activated T cells in the synovial fluid of arthritic patients. Characterization and comparison with in vitro activated human and murine T cells in cooperation with monocytes in cytotoxicity. J Immunol 122:878–883

    PubMed  CAS  Google Scholar 

  34. Hamilton ME, Winfield JB (1979) Tγ cells in systemic lupus erythematosus. Variation with disease activity. Arthritis Rheum 22:1–6

    Article  PubMed  CAS  Google Scholar 

  35. Haynes BF, Mann DL, Hemler ME, Schroer JA, Schelhamer JH, Eisenbarth GS, Strominger JL, Thomas CA, Mostowski HS, Fauci AS (1980) Characterization of a monoclonal antibody that defines an immunoregulatory subset for immunoglobulin synthesis in humans. Proc Natl Acad Sci USA 77:2914–2918

    Article  PubMed  CAS  Google Scholar 

  36. Hayward AR, Layward L, Lydyard PM, Moretta L, Dagg M, Lawton AR (1978) Fc-receptor heterogeneity of human suppressor T cells. J Immunol 121: 1–5

    PubMed  CAS  Google Scholar 

  37. Horwitz DA, Juul-Nielsen K (1977) Human blood L lymphocytes in patients with active systemic lupus erythematosus, rheumatoid arthritis and scleroderma: A comparison with T and B cells. Clin Exp Immunol 30:370–376

    PubMed  CAS  Google Scholar 

  38. Horwitz DA, Niaudet P, Greaves MF, Dorling J, Deteix P (1978) Surface markers and electron microscopy of human blood L cells: A comparison with T and B lymphocytes. J Immunol 121:678–684

    PubMed  CAS  Google Scholar 

  39. Höyeraal HM, Fröland SS, Wislöff F (1975) Lymphocyte populations and cellular immune reactions in juvenile rheumatoid arthritis. Scand J Immunol 4:801–810

    PubMed  Google Scholar 

  40. Kay HD, Horwitz DA (1980) Evidence by reactivity with hybridoma antibodies for a probable myeloid origin of peripheral blood cells active in natural cytotoxicity and antibody-dependent cellmediated cytotoxicity. J Clin Invest 66:847–851

    Article  PubMed  CAS  Google Scholar 

  41. Knowles DM, Hoffman HT, Ferrarini M, Kunkel HG (1978) The demonstration of acid α-naphthyl acetate esterase activity in human lymphocytes: Usefulness as a T-cell marker. Cell Immunol 35:112–123

    Article  PubMed  CAS  Google Scholar 

  42. Kobayashi I, Ziff M (1973) Electron microscopic studies of lymphoid cells in the rheumatoid synovial membrane. Arthritis Rheum 16:471–486

    Article  PubMed  CAS  Google Scholar 

  43. Konttinen YT, Reitamo S, Ranki A, Häiry P (1980) Isolation and in situ characterization of inflammatory cells in rheumatoid synovia. Abstr. 14.7.34, 4th International Congress of Immunology, Paris, July 1980

    Google Scholar 

  44. Loewi G, Lance EM, Reynolds J (1975) Study of lymphoid cells from inflamed synovial membranes. Ann Rheum Dis 34:524–528

    Article  PubMed  CAS  Google Scholar 

  45. Manconi PE, Fadda MF, Cadoni A, Cornaglia P, Zacceo D, Grifoni V (1978) Subpopulations of T lymphocytes in human extravascular fluid. Int Arch Allergy 56:384–393

    Article  Google Scholar 

  46. Meijer CJLM, Lafever GHM, Cnossen J, Damsteeg WGM, Cats A (1980) T lymphocyte subpopulations in rheumatoid arthritis. Abstr. 14.7.41. 4th International Congress of Immunology, Paris, July 1980

    Google Scholar 

  47. Meijer CJLM, van de Putte LBA, Lafeber GJM, de Haas E, Cats A (1980) Membrane and transformation characteristics of lymphocytes isolated from the synovial membrane and paired peripheral blood of patients with rheumatoid arthritis. Ann Rheum Dis 39:75–81

    Article  PubMed  CAS  Google Scholar 

  48. Mellbye OJ, Messner, RP, DeBord JR, Williams RC (1972) Immunoglobulin and receptors for C3 on lymphocytes from patients with rheumatoid arthritis. Arthritis Rheum 15:371–379

    Article  PubMed  CAS  Google Scholar 

  49. Moretta L, Webb SR, Grossi CE, Lydyard PM, Cooper MD (1977) Functional analysis of two human T cell sub-populations, help and suppression of B cell responses by T cells bearing receptors for IgM and IgG. J Exp Med 146:184–200

    Article  PubMed  CAS  Google Scholar 

  50. Papamichail M, Brown JC, Holborow EJ (1971) Immunoglobulins on the surface of human lymphocytes. Lancet II:850–852

    Article  Google Scholar 

  51. Pichler W, Lum L, Broder S (1978) Fc-receptors on human T lymphocytes. I. Transition of Tγ to Tµ cells. J Immunol 121:1540–1546

    PubMed  CAS  Google Scholar 

  52. Reinherz EL, Moretta L, Roper M, Breard J, Mingari MC, Cooper MD, Schlossman SF (1980) Human T lymphocytes subpopulations defined by Fc receptors and monoclonal antibodies. A comparison. J Exp Med 151:969–974

    Article  PubMed  CAS  Google Scholar 

  53. Sany J, Clot J, Rosenberg F, Serre H (1977) Etude des lymphocytes T et B dans le sang et le liquide synovial au cours de la polyarthrite rhumatoide. Rev Rhum 44:317–329

    PubMed  CAS  Google Scholar 

  54. Sharpin RKC, Wilson JD (1977) Studies on the nature of EA binding by lymphocytes from rheumatoid arthritis patients. Clin Exp Immunol 29: 213–219

    PubMed  CAS  Google Scholar 

  55. Sheldon PJ, Papamichail M, Holborow EJ (1974) Studies on synovial fluid lymphocytes in rheumatoid arthritis. Ann Rheum Dis 33:509–514

    Article  PubMed  CAS  Google Scholar 

  56. Shiftan TA, Mendelsohn J (1978) The circulating “atypical” lymphocyte. Hum Pathol 9:51–61

    Article  PubMed  CAS  Google Scholar 

  57. Strelkauskas AJ, Callery RT, McDowell J, Borel J, Schlossman SF (1978) Direct evidence for the loss of human suppressor cells during active autoimmune disease. Proc Natl Acad Sci USA 75:5150–5154

    Article  PubMed  CAS  Google Scholar 

  58. Tan RS-H, Byrom NA, Hayes JP (1975) A method of liberating living cells from the dermal infiltrate: Studies on skin reticuloses and lichen planus. Br J Dermatol 93:271–281

    Article  PubMed  CAS  Google Scholar 

  59. Tannenbaum H, Pinkus GS, Anderson LG, Schur PH (1975) Immunologic characterisation of the mononuclear cell infiltrates in rheumatoid synovia, in rheumatoid nodules, and in lip biopsies from patients with Sjögren’s syndrome. Arthritis Rheum 18:305–314

    Article  PubMed  CAS  Google Scholar 

  60. Traycoff RB, Pascual E, Schumacher HR (1976) Mononuclear cells in human synovial fluid. Identification of lymphoblasts in rheumatoid arthritis. Arthritis Rheum 19:743–748

    Article  PubMed  CAS  Google Scholar 

  61. Van Boxel JA, Paget SA (1975) Predominantly T-cell infiltrate in rheumatoid synovial membranes. N Engl J Med 293:517–520

    Article  PubMed  Google Scholar 

  62. Van de Putte LBA, Meijer CJLM, Lafeber GJM, Kleinjan R, Cats A (1976) Lymphocytes in rheumatoid and nonrheumatoid synovial fluids. Ann Rheum Dis 35:451–455

    Article  Google Scholar 

  63. Waldman TA, Broder S (1978) T cell disorders in primary immunodeficiency diseases. Semin Immunopathol 1:239–270

    Article  Google Scholar 

  64. Wangel A, Klockars M (1977) Lymphocyte subpopulations in rheumatoid synovial tissue. Ann Rheum Dis 36:176–180

    Article  PubMed  CAS  Google Scholar 

  65. Williams RC, DeBord JR, Mellbye OJ, Messner RP, Lindstrom FD (1973) Studies of T- and B-lymphocytes in patients with connective tissue diseases. J Clin Invest 52:283–295

    Article  PubMed  Google Scholar 

  66. Winchester RJ, Winfield JB, Siegal R, Wernet P, Bentwich Z, Kunkel HG (1974) Analyses of lymphocytes from patients with rheumatoid arthritis and systemic lupus erythematosus. J Clin Invest 54:1082–1092

    Article  PubMed  CAS  Google Scholar 

  67. Winchester RJ, Hoffman T, Ferrarini M, Ross GD, Kunkel HG (1979) Corner parison of various tests for Fc receptors on different human lymphocyte subpopulations. Clin Exp Immunol 37:126–133

    PubMed  CAS  Google Scholar 

  68. Wooley PH, Panayi GS (1978) Studies of lymphocytes in rheumatoid arthritis. I. Uptake of 125 J-heat aggregated human IgG by Fc-receptor bearing lymphocytes. Ann Rheum Dis 37:343–346

    Article  PubMed  CAS  Google Scholar 

  69. Yu DTY, Winchester RJ, Fu SM, Gitofsky A, Ko HS, Kunkel HG (1980) Peripheral blood la-positive T cells. Increases in certain diseases and after immunization. J Exp Med 151:91–100

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Frøland, S.S. (1981). Lymphocyte Populations and Subpopulations in Rheumatoid Arthritis. In: Deicher, H., Schulz, LC. (eds) Arthritis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68106-6_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-68106-6_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10781-1

  • Online ISBN: 978-3-642-68106-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics