Arthritis pp 137-143 | Cite as

Enzyme Histochemical Demonstration of Certain Cell Populations in Synovium Using Plastic-Embedded Whole Rat Joints

  • W. Hermanns
  • L. C. Schulz


Recent results in experimental arthritis research point to the possible importance of blood-born cells in the pathogenesis of chronic polyarthritis. Westerhellweg and Mohr [27], in adjuvant arthritis of rats, and Mohr and Wessinghage [14], in cases of human chronic polyarthritis, observed neutrophil granulocytes in the immediate vicinity of pannus-mediated destruction of articular cartilage. Autoradiographic studies in experimental allergic arthritis of guinea pigs led Ricken et al. [20] to assume that part of the hyperplastic synovial lining cells are progeny of myelogenic monocytes. Both these cell types possess fairly characteristic enzyme markers. Neutrophils show a comparatively high activity of naphthol-AS-D-chloroacetate-esterase [23], while monocytes/macrophages, on the other hand, are characterized by a diffuse reaction product of α-naphthyl-butyrateesterase [1].


Enzyme Histochemistry Glycol Monomethyl Ether Ethylene Glycol Monomethyl Ether Monobutyl Ether Glycol Monobutyl Ether 
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© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • W. Hermanns
  • L. C. Schulz

There are no affiliations available

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