Skip to main content

Conditions of Vessel Wall Deposition of Immune Complexes in Immunologically Induced Vascular Diseases

  • Conference paper
Arthritis

Summary

Conditions of vessel wall deposition of immune complexes have been studied mainly with regard to factors influencing immune complex deposition in the kidney. Two mechanisms are apparently involved. In the first, the deposition of circulating complexes in the glomerulus is due to the trapping of complexes in subendothelial and mesangial regions. The second mechanism, resulting in localization of complexes within the basement membrane, is thought to be caused by local formation of immune complexes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cochrane CG, Koffler D (1973) Immune complex disease in experimental animals and man. Adv Immunol 16:185

    Article  PubMed  CAS  Google Scholar 

  2. Border WA (1979) Immune complex detection in glomerular diseases. Nephron 24:105

    Article  PubMed  CAS  Google Scholar 

  3. Michael AF, Drummond KN, Good RA, Vernier RL (1966) Acute streptococcal glomerulonephritis. Immune deposit disease. J Clin Invest 45:237

    Article  PubMed  Google Scholar 

  4. Koffler D, Agnello U, Thoburn R, Kunkel HG (1971) Systemic lupus erythematosus: Prototype of immune complex nephritis in man. J Exp Med 134: 169

    Article  PubMed  CAS  Google Scholar 

  5. Peress NS (1980) Immune complex deposition in the ciliary process of rabbits with acute and chronic serum sickness. Exp Eye Res 30:371

    Article  PubMed  CAS  Google Scholar 

  6. Theofilopoulos AN, Wilson CB, Dixon FJ (1976) The Raji cell radioimmune assay for detecting immune complexes in human sera. J Clin Invest 57:169

    Article  PubMed  CAS  Google Scholar 

  7. Bayer AS, Theofilopoulos AN, Eisenberg R, Dixon FJ, Guze LB (1976) Circulating immune complexes in infective endocarditis. N Engl J Med 295:1500

    Article  PubMed  CAS  Google Scholar 

  8. Jewell DP, MacLennan ICM (1973) Circulating immune complexes in inflammatory bowel disease. Clin Exp Immunol 14:219

    PubMed  CAS  Google Scholar 

  9. Teshima H, Wanebo H, Pinsky C, Day NK (1977) Circulating immune complexes detected by 125I-C1q deviation test in sera of cancer patients. J Clin Invest 59:1134

    Article  PubMed  CAS  Google Scholar 

  10. Theofilopoulos AN, Andrews BS, Urist MM, Morton DL, Dixon FJ (1977) The nature of immune complexes in human cancer serum. J Immunol 119:657

    PubMed  CAS  Google Scholar 

  11. Germuth FG Jr, Roāriguez E (1973) Immunopathology of the renal glomerulus: Immune complex deposit and anti-basement membrane disease. Little Borwn, Boston

    Google Scholar 

  12. Cochrane CG, Hawkins D (1968) Studies on circulating immune complexes. III. Factors governing the ability of circulating complexes to localize in blood vessels. J Exp Med 127:137

    Article  PubMed  CAS  Google Scholar 

  13. Cochrane CG (1971) Mechanisms involved in the deposition of immune complexes in tissues. J Exp Med 134:75

    Article  PubMed  CAS  Google Scholar 

  14. Henson PM, Cochrane CG (1971) Immune complex disease in rabbits. The role of complement and of a leucocyte dependent release of vasoactive amines from platelets. J Exp Med 133:554

    Article  PubMed  CAS  Google Scholar 

  15. Kniker WT, Cochrane CG (1968) The localization of circulating immune complexes in experimental serum sickness. The role of vasoactive amines and hydrodynamic forces. J Exp Med 127:119

    Article  PubMed  CAS  Google Scholar 

  16. Mannik M, Haakenstad AO, Arend WP (1974) The fate and detection of circulating immune complexes. In: Brent L, Holborow (eds) Progress in immunology II, vol 5. North Holland, Amsterdam Oxford New York, p 91

    Google Scholar 

  17. Kijlstra A, Knutson DW, van der Lelij A, van Es LA (1977) Characteristics of soluble immune complexes prepared from oligovalent DNP conjugates and anti-DNP antibodies. J Immunol Methods 17:263

    Article  PubMed  CAS  Google Scholar 

  18. Christian CL (1960) Studies of aggregated γ-globulin. I. Sedimentation, electrophoretic and anticomplementary properties. J Immunol 84:112

    PubMed  CAS  Google Scholar 

  19. Knutson DW, Kijlstra A, van Es LA (1977) Association and dissociation of aggregated IgG from rat peritoneal macrophages. J Exp Med 145:1368

    Article  PubMed  CAS  Google Scholar 

  20. Mauer SM, Fish AJ, Blau EB, Michael AF (1972) The glomerular mesangium. I. Kinetic studies of macro-molecular uptake in normal and nephrotic rats. J Clin Invest 51:1092

    Article  PubMed  CAS  Google Scholar 

  21. Knutson DW, Kijlstra A, Lentz H, van Es LA (1979) Isolation of stable aggregates of IgG by zonal ultracentrifugation in sucrose-gradients containing albumin. Immunol Commun 8:337

    PubMed  CAS  Google Scholar 

  22. Kauffmann RH, Dana MR, Kijlstra A, Knutson DW, van Es LA (1979) Preparation of stabilized human IgG aggregates of known size and their reactivity in immune complex assays. In: Peeters H (ed) Protides of the biological fluids. Pergamon, Oxford, p 21

    Google Scholar 

  23. Kauffmann RH, van Es LA, Daha MR (1979) Aggregated human immunoglobulin G stabilized by albumin: A standard for immune complex detection. J Immunol Methods 31:11

    Article  PubMed  CAS  Google Scholar 

  24. Van Es LA, Daha MR, Kijlstra A (1979) Clearance of soluble immune complexes and aggregates. In: Peeters H (ed) Protides of the biological fluids. Pergamon, Oxford, p 159

    Google Scholar 

  25. Benacerraf B, Sebestyen M, Cooper NS (1959) The clearance of antigen antibody complexes from the blood by the reticulo-endothelial system. J Immunol 82:131

    PubMed  CAS  Google Scholar 

  26. Arend WP, Mannik M (1971) Studies on antigen-antibody complexes. II. Quantification of tissue uptake of soluble complexes in normal and complement-depleted rabbits. J Exp Med 107:63

    CAS  Google Scholar 

  27. Haakenstad AO, Mannik M (1974) Saturation of the reticulo-endothelial system with soluble immune complexes. J Immunol 112:1939

    PubMed  CAS  Google Scholar 

  28. Kijlstra A, van der Lelij A, Knutson DW, Fleuren GJ, van Es LA (1978) The influence of phagocyte function on glomerular localization of aggregated IgM in rats. Clin Exp Immunol 32:207

    PubMed  CAS  Google Scholar 

  29. Frank MM, Schreiber AD, Atkinson JP, Jaffe CJ (1977) Pathophysiology of immune hemolytic anemia. Ann Intern Med 87:210

    Google Scholar 

  30. Hopff U, Meyer zum Büschenfelde KH, Dierich MP (1976) Demonstration of binding sites for IgG Fc and the third complement component (3) on isolated hepatocytes. J Immunol 117:639

    Google Scholar 

  31. Phillips-Quagliata JM, Levine BB, Quagliata F, Uhr JW (1971) Mechanisms underlying binding of immune complexes to macrophages. J Exp Med 133:589

    Article  PubMed  CAS  Google Scholar 

  32. Arend WP, Mannik M (1972) In vitro adherence of soluble immune complexes to macrophages. J Exp Med 136:415

    Article  Google Scholar 

  33. Leslie RGQ, Alexander MD, Cohen S (1977) Binding of immune complexes of guinea pig IgG2 to homologous peritoneal exudate cells. Eur J Immunol 6:841

    Article  Google Scholar 

  34. Kijlstra A, van Es LA, Daha MR (1979) Enhanced degradation of soluble immunoglobulin aggregates by macrophages in the presence of complement. Immunology 37:673

    PubMed  CAS  Google Scholar 

  35. Van Snick JC, van Roost E, Markowetz B, Cambiaso CL, Masson PL (1978) Enhancement by IgM rheumatoid factor of in vitro ingestion by macrophages and in vivo clearance of aggregated IgG or antigen-antibody complexes. Eur J Immunol 8:279

    Article  PubMed  Google Scholar 

  36. Van Snick JC, Masson PL (1978) The effect of complement on the ingestion of soluble antigen-antibody complexes andlgM aggregates by mouse peri toneal macrophages. J Exp Med 148:903

    Article  PubMed  Google Scholar 

  37. Kijlstra A, van Es LA, Daha MR (1979) The role of complement in the binding and degradation of immunoglobulin aggregates by macrophages. J Immunol 123:2488

    PubMed  CAS  Google Scholar 

  38. Ford PM (1975) The effect of manipulation of reticulo-endothelial system activity on glomerular deposition of aggregated protein and immune complexes in two different strains of mice. Br J Exp Pathol 56:523

    PubMed  CAS  Google Scholar 

  39. Haakenstad AO, Striker GE, Mannik M (1976) The glomerular deposition of soluble immune complexes prepared with reduced and alkylated antibodies and with intact antibodies in mice. Lab Invest 35:293

    PubMed  CAS  Google Scholar 

  40. Kijlstra A, Knutson DW, Daha MR, van Es LA (1979) Clearance and glomerular localization of preformed DNP/anti-DNP immune complexes. Scand J Immunol 10:421

    Article  PubMed  CAS  Google Scholar 

  41. Lightfoot RW, Drusin RE, Christian CL (1970) Properties of soluble immune complexes. J Immunol 105:1493

    PubMed  CAS  Google Scholar 

  42. Soothill JF, Steward MW (1971) The immunopathological significance of the heterogeneity of antibody affinity. Clin Exp Immunol 9:193

    PubMed  CAS  Google Scholar 

  43. Koyama A, Niwa Y, Shigematsu H, Taniguhi M, Tada T (1978) Studies on passive serum sickness. II. Factors determining the localization of antigen-antibody complexes in the murine renal glomerulus. Lab Invest 38:253

    PubMed  CAS  Google Scholar 

  44. Gabbiani G, Badonnel MC, Vassalli P (1975) Experimental focal glomerular lesions elicited by insoluble immune complexes. Ultrastructural and immunofluorescent studies. Lab Invest 32:33

    PubMed  CAS  Google Scholar 

  45. Schifferli JA, Bartolotti SR, Peters DK (1980) Inhibition of immune precipitation by complement (Abstract). 4th Intern Congress of Immunol 15:3.24

    Google Scholar 

  46. Couser WG, Salant DJ (1980) In situ immune complex formation and glomerular injury. Kidney Int 17:1

    Article  PubMed  CAS  Google Scholar 

  47. Ooi YM, Vallota EH, West CD (1977) Serum immune complexes in membranoproliferative and other glomerulonephritides. Kidney Int 11:275

    Article  PubMed  CAS  Google Scholar 

  48. Van Damme BJC, Fleuren GJ, Bakker WW, Vernier RL, Hoedemaeker PJ (1978) Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. Fixed glomerular antigens in the pathogenesis of the heterologous immune complex glomerulonephritis. Lab Invest 38:502

    PubMed  Google Scholar 

  49. Van Es LA, Blok RPR, Schoenfeld L, Glassock RJ (1977) Chronic nephritis induced by antibodies reacting with glomerular-bound immune complexes. Kidney Int 11:106

    Article  PubMed  Google Scholar 

  50. Izui S, Lambert PH, Miescher PA (1976) In vitro demonstration of a particular affinity of glomerular basement membrane of collagen for DNA. A possible basis for a local formation of DNA/anti-DNA complexes in systemic lupus erythematosus. J Exp Med 144:428

    Article  PubMed  CAS  Google Scholar 

  51. Rahi AHS, Holborow EJ, Perkins ES, Gungen YY, Dinning WJ (1976) Immunological investigations in uveitis. Trans Ophthalmol Soc UK 96:113

    PubMed  CAS  Google Scholar 

  52. Dernouchamps JP, Vaerman JP, Michiels J, Masson PL (1977) Immune complexes in the aqueous humor and serum. Am J Ophthalmol 84:24

    PubMed  CAS  Google Scholar 

  53. Andrews BS, Mclntosh J, Petts V, Penny R (1979) Circulating immune complexes in acute uveitis: A possible association with the histocompatibility complex locus antigen B27. Int Arch Allergy Appl Immun 58:313

    Article  CAS  Google Scholar 

  54. Char DH, Stein P, Masi R, Christensen M (1979) Immune complexes in uveitis. Am J Ophthalmol 87:678

    PubMed  CAS  Google Scholar 

  55. Howes EL Jr, McKay DG, Aronson SB (1971) An ultrastructural study of the ciliary process in the rabbit following systemic administration of bacterial endotoxin. Lab Invest 24:217

    PubMed  CAS  Google Scholar 

  56. Gamble CN, Aronson SB, Brescia FB (1970) The pathogenesis of recurrent immunologic (Auer) uveitis. Arch Ophthalmol 84:331

    PubMed  CAS  Google Scholar 

  57. Rosenbaum JT, McDevitt HO, Guss RB, Egbert PR (1980) Endotoxin-induced uveitis in rats as a model for human disease. Nature 286:611

    Article  PubMed  CAS  Google Scholar 

  58. Scharf Y, Zonis S (1980) Histocompatibility antigens (HLA) and uveitis. Surv Ophthalmol 24:220

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Kijlstra, A., Hylkema, H.A., van Es, L.A. (1981). Conditions of Vessel Wall Deposition of Immune Complexes in Immunologically Induced Vascular Diseases. In: Deicher, H., Schulz, LC. (eds) Arthritis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68106-6_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-68106-6_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10781-1

  • Online ISBN: 978-3-642-68106-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics