Abstract
The hemodynamic changes which follow systemic application of nitrates are the result of changes at three different points — in the coronary arteries, the myocardium and the peripheral vessels. In order to differentiate between the effects on the heart and those on the peripheral vessels, we administered isosorbide dinitrate directly in the coronary arteries and in the systemic circulation and studied changes in regional wall motion, contractility, and pump function under resting conditions.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Cohen MU, Dauney JM, Sonnenblick EA, Kirk ES (1973) The effects of nitroglycerin on coronary collaterals and myocardial contractility. J Clin Invest 52: 2836–2847
Ganz W, Marcus HS (1972) Failure of intracoronary nitroglycerin to alleviate pacing-induced angina. Circulation 56: 880–889
Korth M (1975) Influence of glyceryl trinitrate on force of contraction and action potential of guinea-pig myocardium. Naunyn-Schmiedeberg’s Arch Pharmacol 287: 329–347
Strauer BE (1973) The effects of nitroglycerin on myocardial contractility. Z Kardiol 62: 97–111
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Rutsch, W., Schmutzler, H. (1981). Left Ventricular Function and Regional Wall Motion After Intracoronary Application of Nitrates in Coronary Heart Disease. In: Lichtlen, P.R., Engel, HJ., Schrey, A., Swan, H.J.C. (eds) Nitrates III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68085-4_20
Download citation
DOI: https://doi.org/10.1007/978-3-642-68085-4_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-68087-8
Online ISBN: 978-3-642-68085-4
eBook Packages: Springer Book Archive