Advertisement

Nitrates III pp 126-133 | Cite as

Direct and Indirect Effects of Nitroglycerin on Systolic and Diastolic Left Ventricular Function

  • I. Amende
  • R. Simon
  • W. P. HoodJr.
  • W. Daniel
  • P. Lichtlen

Abstract

The basic pharmacological property of nitrites is to relax smooth muscle, and the well-documented hemodynamic effects of these drugs have generally been thought to be secondary to their actions on vascular smooth muscle [5, 11]. Direct cardiac effects have remained largely undetermined or controversial. We have studied the actions of nitroglycerin (NTG) on left ventricular (LV) function in man administered by the sublingual (SL) [1] route and by intracoronary (IC) injection [6]. This approach allowed separation of direct (cardiac) and indirect (peripheral) effects of the drug.

Keywords

Left Main Coronary Artery Diastolic Left Ventricular Function Muscle Stiffness Left Ventricular Geometry Global Systolic Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Amende I, Simon R, Hood WP jr, Lichtlen P (1979) The effects of the beta-blocker atenolol and nitroglycerin on left ventricular function and geometry in man. Circulation 60: 836PubMedGoogle Scholar
  2. 2.
    Gaasch WH, Bernard SA (1977) The effect of acute changes in coronary blood flow on left ventricular end-diastolic wall thickness: An echocardiographic study. Circulation 56: 593PubMedGoogle Scholar
  3. 3.
    Gaasch WH, Levine HJ, Quinones MA, Alexander JK (1976) Left ventricular compliance: Mechanisms and clinical implications. Am J Cardiol 38: 645PubMedCrossRefGoogle Scholar
  4. 4.
    Ganz W, Marcus HS (1972) Failure of intracoronary nitroglycerin to alleviate pacing-induced angina. Circulation 46: 880PubMedGoogle Scholar
  5. 5.
    Hickerson M (1970) Vasodilator drugs. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics, 4 th edn. MacMillan, New York, p 745Google Scholar
  6. 6.
    Hood WP jr, Amende I, Simon R, Lichtlen PR (1980) The effects of intracoronary nitroglycerin on left ventricular systolic and diastolic function in man. Circulation 61: 1098PubMedGoogle Scholar
  7. 7.
    Mason DT (1969) Usefulness and limitations of the rate of rise of intraventricular pressure (dP/dt) in the evaluation of myocardial contractility in man. Am J Cardiol 23: 516PubMedCrossRefGoogle Scholar
  8. 8.
    Mirsky I (1976) Assessment of passive elastic stiffness of cardiac muscle: Mathematical concepts, physiologic and clinical considerations, direction of future research. Prog Cardiovasc Dis 18: 277PubMedCrossRefGoogle Scholar
  9. 9.
    Salisbury PF, Cross CE, Rieben PA (1980) Influence of coronary artery pressure upon myocardial elasticity. Circ Res 8: 794Google Scholar
  10. 10.
    Templeton GH, Wildenthal K, Mitchell JH (1972) Influence of coronary blood flow on left ventricular contractility and stiffness. Am J Physiol 223: 1216PubMedGoogle Scholar
  11. 11.
    Vatner SF, Heyndrickx GR (1975) Mechanisms of action of nitroglycerin: Coronary, cardiac, and systemic effects. In: Needleman P (ed) Organic Nitrates. Springer, Berlin Heidelberg New York (Handbook of Experimental Pharmacology, volume 40, p. 131 )Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • I. Amende
  • R. Simon
  • W. P. HoodJr.
  • W. Daniel
  • P. Lichtlen

There are no affiliations available

Personalised recommendations