Nitrates III pp 126-133 | Cite as

Direct and Indirect Effects of Nitroglycerin on Systolic and Diastolic Left Ventricular Function

  • I. Amende
  • R. Simon
  • W. P. HoodJr.
  • W. Daniel
  • P. Lichtlen


The basic pharmacological property of nitrites is to relax smooth muscle, and the well-documented hemodynamic effects of these drugs have generally been thought to be secondary to their actions on vascular smooth muscle [5, 11]. Direct cardiac effects have remained largely undetermined or controversial. We have studied the actions of nitroglycerin (NTG) on left ventricular (LV) function in man administered by the sublingual (SL) [1] route and by intracoronary (IC) injection [6]. This approach allowed separation of direct (cardiac) and indirect (peripheral) effects of the drug.


Left Main Coronary Artery Diastolic Left Ventricular Function Muscle Stiffness Left Ventricular Geometry Global Systolic Function 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • I. Amende
  • R. Simon
  • W. P. HoodJr.
  • W. Daniel
  • P. Lichtlen

There are no affiliations available

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