Direct and Indirect Effects of Nitroglycerin on Systolic and Diastolic Left Ventricular Function
The basic pharmacological property of nitrites is to relax smooth muscle, and the well-documented hemodynamic effects of these drugs have generally been thought to be secondary to their actions on vascular smooth muscle [5, 11]. Direct cardiac effects have remained largely undetermined or controversial. We have studied the actions of nitroglycerin (NTG) on left ventricular (LV) function in man administered by the sublingual (SL)  route and by intracoronary (IC) injection . This approach allowed separation of direct (cardiac) and indirect (peripheral) effects of the drug.
KeywordsLeft Main Coronary Artery Diastolic Left Ventricular Function Muscle Stiffness Left Ventricular Geometry Global Systolic Function
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