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Induction and Inhibition of Organic Nitrate Metabolism

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Nitrates III

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Abstract

Organic nitrate vasodilators, such as glyceryl trinitrate (GTN) or isosorbide dinitrate (ISDN), are denitrated by the glutathione (GSH) S-transferases (EC 2.5.1.18) according to the general scheme [3]: RONO2+GSH→RHO+HNO2+GSSG.

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References

  1. Chasseaud LF, Down WH, Sacharin RM (1978) Effect of repeated oral administration of isosorbide dinitrate on hepatic glutathione S-transferase activity in the rat. Biochem Pharmacol 27: 1695

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  2. Down WH, Chasseaud LF (1979) Effect of repeated oral administration of phenobarbitone or DDT on hepatic glutathione S-transferase activity in non-human primates: comparison with the rat. Biochem Pharmacol 28: 3525

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  3. Jakoby WB, Habig WH, Ketley JN, Pabst MJ (1976) Glutathione S-transferases: Catalytic aspects. In: Glutathione: Metabolism and Function. Arias IM, Jakoby WB (Eds). Raven Press, New York, p. 189

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  4. Kosower EM, Kosower NS (1976) Chemical basis of the perturbation of glutathione-glutathione disulphide status of biological systems by diazenes. In: Glutathione: Metabolism and Function. Arias IM, Jakoby WB (Eds). Raven Press, New York, p. 139

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  5. Needleman P, Johnson EM (1975): The pharmacological and biochemical interaction of organic nitrates with sulfhydryls: possible correlations with the mechanism for tolerance development, vasodilation and mitochondrial and enzyme reactions. In: Organic Nitrates. Needleman P (Ed) Springer, Berlin Heidelberg New York, p 97

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  6. Thadani U, Manyari D, Parker JO, Fung HL (1980) Tolerance to the circulatory effects of oral isosorbide dinitrate. Circulation 61: 526

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Authors
  1. W. H. Down
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  2. L. F. Chasseaud
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  3. S. A. Ballard
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Editor information

Editors and Affiliations

  1. Abteilung für Kardiologie, Med. Hochschule Hannover, Karl-Wiechert-Allee 9, D-3000, Hannover 61, Germany

    P. R. Lichtlen

  2. Zentralkrankenhaus „Links der Weser“, Senator-Weßling-Straße, D-2800, Bremen 61, Germany

    H.-J. Engel

  3. Pharma-Schwarz GmbH, D-4019, Monheim, Germany

    A. Schrey

  4. Dept. of Cardiology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, 90048, Los Angeles, Calif., USA

    H. J. C. Swan (Director) (Director)

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© 1981 Springer-Verlag Berlin Heidelberg

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Down, W.H., Chasseaud, L.F., Ballard, S.A. (1981). Induction and Inhibition of Organic Nitrate Metabolism. In: Lichtlen, P.R., Engel, HJ., Schrey, A., Swan, H.J.C. (eds) Nitrates III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68085-4_16

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  • DOI: https://doi.org/10.1007/978-3-642-68085-4_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68087-8

  • Online ISBN: 978-3-642-68085-4

  • eBook Packages: Springer Book Archive

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