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A New Topical Drug Delivery System for Nitroglycerin

  • B. Pitt
  • H. Colfer
  • A. Keith
  • P. Stetson
  • J. Walton
  • J. Brymer
  • A. Golub
  • B. Lucchesi
Conference paper

Abstract

Nitroglycerin has been the agent of choice for the treatment of angina pectoris for over 100 years. In recent years various long-acting preparations have been introduced for the prophylaxis of angina pectoris and most recently for use in the long term management of a patient with left ventricular dysfunction. These long-acting preparations including nitroglycerin ointment, slow release oral nitroglycerin, and “ long-acting” nitrates, such as isosorbide dinitrate and pentaerytritol trinitrate have found wide acceptance. The effectiveness and acceptance of these preparations is, however, limited by the need to administer them every 4–6 h with resultant difficulties in patient compliance and variation in absorption. Variation in absorption is found with the oral preparations but may be worse with the use of ointments which are often applied in a variable manner from application to application. This paper reports upon the development and initial human use of a new topical drug delivery system for nitroglycerin with a duration of action of a minimum of 24 h.

Keywords

Polymer Matrix Angina Pectoris Isosorbide Dinitrate Sublingual Nitroglycerin Human Cadaver Skin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Reference

  1. 1.
    Danahy DT, Aronow WS (1977) Hemodynamics and antianginal effects of high dose oral isorbide dinitrate after chronic use. Circulation 56: 205–212PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • B. Pitt
  • H. Colfer
  • A. Keith
  • P. Stetson
  • J. Walton
  • J. Brymer
  • A. Golub
  • B. Lucchesi

There are no affiliations available

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