Chronic Isolation of Visual Cortex Induces Reorganization of Cortico-Cortical Connections

  • M. Holzgraefe
  • G. Teuchert
  • J. R. Wolff
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


Undercutting of the cortex destroys all subcortical afferents and efferents, leaving most cortico-cortical connections intact (Szentágothai 1965). The resulting terminal degeneration shows a laminar pattern similar to thalamo-cortical projections (Hubel and Wiesel 1972; Ogren and Hendrickson 1977; Gould et al. 1978), although the synaptic density is slightly reduced (Clark et al. 1939; Gruner et al. 1974). Chronic isolation results in the survival of the majority of neurons (Creutzfeldt and Struck 1962).


Visual Cortex Dentate Gyrus Laminar Distribution Fiber Degeneration Laminar Pattern 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • M. Holzgraefe
    • 1
    • 2
  • G. Teuchert
    • 1
    • 3
  • J. R. Wolff
    • 1
    • 4
  1. 1.Zentrum AnatomieUniversität GöttingenGöttingenGermany
  2. 2.Neurologische Universitäts-KlinikGöttingenGermany
  3. 3.Fachbereich BiologieUniversität BielefeldBielefeldGermany
  4. 4.Abteilung NeurobiologieMax-Planck-Institut für biophysikalische ChemieGöttingenGermany

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