Abstract
Epidermodysplasia verruciformis (EV) is a disease ordinarily beginning in childhood and characterized by widespread chronic pityriasis versicolor-like lesions (PV-like), multiple bowenoid cancers, and usually depressed cell-mediated immunity (5). It has been shown that benign lesions are induced by human papillomavirus group 5 (HPV-5) (9), and that HPV-5 is potentially oncogenic since most all patients with the severe form of EV have skin cancers and those cancers so far studied contain multiple copies of this viral genome (8).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bollag W (1974) Therapeutic effects of an aromatic retinoic acid analog on chemically induced skin papillomas and carcinomas of mice. Eur J Cancer 10: 731–737
Glazer M, Lotan R (1979) Augmentation of specific tumor immunity against a syngeneic SV40-induced sarcoma in mice by retinoic acid. Cell Immunol 45: 175–181
Guilhou JJ, Malbos S, Barnéon S, Habib A, Baldet P, Meynadier J (1980) Epidermodysplasie verruciforme (2 observations). Etude immunologique. Ann Dermatol Venereol 107: 611–619
Ito Y Effect of an aromatic retinoic acid analog (Ro 10-9359) on growth of virus-induced papillomas (Shope) and related neoplasia of rabbits. Eur J Cancer (in press)
Lutzner MA (1978) Epidermodysplasia verruciformis. An autosomal recessive disease characterized by viral warts and skin cancer. A model for viral oncogenesis. Bull Cancer 65: 169–182
Lutzner MA, Blanchet-Bardon C (1980) Oral retinoid treatment of human papillomavirus type 5-induced epidermodysplasia verruciformis. N Engl J Med 302: 1091
Migozzi MM, Baréty et al (1965) Epidermodysplasie verruciforme de Lutz-Lewandowsky. Bull Dermatol Syph Fr 72: 747–748
Orth G, Favre M, Breitburd F, Croissant O, Jablonska S, Obalek S, Jarzgbek-Chorzelska M, Rzgsa G Epidermodysplasia verruciformis. A model for the role of papillomaviruses in human cancer. In: Viruses in naturally occurring human cancer. Essex M, Todaro G, Zur Hausen H (eds). Cold Spring Harbor Press, New York (in press)
Orth G, Jablonska S, Favre M, Croissant O, Jarzabek-Chorzelska M, Rzgsa G (1978) Characterization of two types of human papillomavirus in lesions of epidermodysplasia verruciformis. Proc Nail Acad Sci USA 75: 1537–1541
Reinhardt A, Sands JA, Snipes W (1979) Virucidal activity of retinal Antimicrob Agents Che-mother 16: 421–423
Rüst O, Rufli T, Forrer J (1979) Erste Erfahrungen mit dem Vitamin-A-Säure-Derivat Ro 109359 bei Virusepitheliomen. Schweiz med Wochenschr 109: 1914–1920
Todaro G, Delarco J, Sporn M (1978) Retinoids block phenotypic cell transformation produced by sarcoma growth factor. Nature 276: 272–274
Tsambaos D, Mahrle G, Orfanos CE (1980) Epidermal changes induced by oral excess of aromatic retinoids in guinea pigs. Arch Dermatol Res 267: 141–152
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Springer-Verlag
About this paper
Cite this paper
Lutzner, M.A., Blanchet-Bardon, C., Puissant, A. (1981). Oral Aromatic Retinoid (Ro 10-9359) Treatment of Two Patients Suffering with the Severe Form of Epidermodysplasia Verruciformis. In: Orfanos, C.E., Braun-Falco, O., Farber, E.M., Grupper, C., Polano, M.K., Schuppli, R. (eds) Retinoids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68023-6_60
Download citation
DOI: https://doi.org/10.1007/978-3-642-68023-6_60
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-68025-0
Online ISBN: 978-3-642-68023-6
eBook Packages: Springer Book Archive