Abstract
Derivatives of vitamin A have been shown to have marked effects on cellular differentiation, possess antineoplastic activities in vivo, and have therapeutic efficacy in a number of dermatologic diseases (7). In addition to having therapeutic efficacy in several disorders of keratinization, 13-cis-retinoic acid has been found to be effective when administered orally to patients with severe cystic acne (7, 8). Such patients have a marked decrease in sebum production (9) as measured by changes in the composition of the surface lipid film. Since this implies an effect upon the sebaceous gland rather than upon follicular keratinization, we studied (5) the effects of 13-cis-retinoic acid on the hamster flank organ, an animal model system which has been extensively used for the study of compounds inhibiting the response of sebaceous glands to androgenic hormones (1, 2, 4, 10).
This work was supported by the Medical Research Service of the Veterans Administration
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References
Ferrari RA, Chakrabarty K, Beyler AL, Wiland J (1978) Suppression of sebaceous gland development in laboratory animals by 17α-propyl testosterone. J Invest Dermatol 71: 320–323
Frost P, Gomez EC (1972) Inhibitors of sex hormones, development of experimental models. In: Advances in Biology of Skin, Vol. XII. Montagna W, Van Scott EJ, Stoughton R (eds). New York, Appleton Century Crofts, pp 403–420
Frost P, Giegel JL, Weinstein GD, Gomez EC (1973) Biodynamic studies of hamster flank organ growth. Hormonal influences. J Invest Dermatol 61: 159–167
Gomez EC, Frost P (1975) Hamster flank organ. Relevance of studies with topically applied antiandrogens In. Animal Models in Dermatology: Relevance to Human Dermatopharmacology and Dermatotoxicology. Maibach H (ed). New York, Churchill-Livingstone, pp 190–202
Gomez EC, Moskowitz RJ (1980) Effect of 13-cis-retinoic acid on the hamster flank organ. J Invest Dermatol 74: 392–397
Hamilton JB, Montagna W (1950) The sebaceous glands of the hamster. I. Morphologic effect of androgens on integumentary structures. Am J Anat 86: 191–233
Peck GL, Yoder FW, Olsen TG, Pandya MD, Butkus D (1978) Treatment of Darier’s disease, lamellar ichthyosis, pityriasis rubra pilaris, cystic acne, and basal cell carcinoma with oral 13cis-retinoic acid. Dermatologica 157 (Suppl 1): 11–12
Peck GL, Olsen TG, Yoder FW, Strauss JS, Downing DT, Pandya MD, Butkus D, Arrand-Battandier J (1979) Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid. N Engl J Med 300: 329–333
Strauss J, Peck GL, Olsen TG, Downing DT, Windhorst DB (1978) Alteration of skin lipid composition by oral 13-cis-retinoic acid: Comparison of pretreatment and treatment values. J Invest Dermatol 70: 223
Voigt W, Hsia SL (1973) The antiandrogenic action of 4-androgten-3-one-17β-carboxylic acid and its methyl ester on hamster flank organ. Endocrinology 92: 1216–1222
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Gomez, E.C. (1981). Effect of Retinoids on the Sebaceous Glands of the Hamster Flank Organ. In: Orfanos, C.E., Braun-Falco, O., Farber, E.M., Grupper, C., Polano, M.K., Schuppli, R. (eds) Retinoids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68023-6_28
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DOI: https://doi.org/10.1007/978-3-642-68023-6_28
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