Retinoids pp 5-11 | Cite as

From Vitamin A to Retinoids: Chemical and Pharmacological Aspects

  • W. Bollag

Abstract

Vitamin A is necessary for the development and maintenance of human life. It cannot be synthesized by the body and must therefore be taken in with the food. Either vitamin A alcohol (retinol) and its esters or β-carotene, a provitamin which is split in the intestine to vitamin A, serve as sources. The most important metabolic products are vitamin A esters, which are stored in the liver, vitamin A aldehyde (retinal), which is necessary in its 11-cis isomer form for visual function and vitamin A acid (retinoic acid).

Keywords

Toxicity Amide Aldehyde Psoriasis Anthracene 

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References

  1. 1.
    Beer P (1962) Untersuchungen über die Wirkung der Vitamin A-Säure. Dermatologica 124: 192–195CrossRefGoogle Scholar
  2. 2.
    Bollag W (1970) Vitamin A and vitamin A acid in the prophylaxis and therapy of epithelial tumours. Int J Vitam Nutr Res 40: 299–314Google Scholar
  3. 3.
    Bollag W, Ótt F (1971) Therapy of actinic keratoses and basal cell carcinomas with local application of vitamin A acid. Cancer Chemother Rep 55: 59–60PubMedGoogle Scholar
  4. 4.
    Bollag W (1974) Therapeutic effects of an aromatic retinoic acid analog on chemically induced skin papillomas and carcinomas of mice. Eur J Cancer 10: 731–737PubMedGoogle Scholar
  5. 5.
    Bollag W (1975) Prophylaxis of chemically induced epithelial tumors with an aromatic retinoic acid analog (Ro 10-9359). Eur J Cancer 11: 721–724PubMedGoogle Scholar
  6. 6.
    Bollag W, Hanck A (1977) From vitamin A to retinoids. Modern trends in the field of oncology and dermatology. Acta Vitamin Enzymol (Milano) 31: 113–123Google Scholar
  7. 7.
    Bollag W (1979) Retinoids and cancer. Cancer Chemother Pharmacol 3: 207–215PubMedCrossRefGoogle Scholar
  8. 8.
    Bollag W, Matter A From vitamin A to retinoids in experimental and clinical oncology: Achievements, failures and outlook. Aim NY Acad Sci (in press)Google Scholar
  9. 9.
    Frost P, Weinstein GD (1969) Topical administration of vitamin A acid for ichthyosiform dermatoses and psoriasis. J Amer Med Assoc 207: 1863–1868CrossRefGoogle Scholar
  10. 10.
    Kligman AM, Fulton JE, Plewig G (1969) Topical vitamin A acid in acne vulgaris. Arch Dermatol 99: 469–476PubMedCrossRefGoogle Scholar
  11. 11.
    Lotan R (1980) Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. Biochim Biophys Acta 605: 33–91PubMedGoogle Scholar
  12. 12.
    Mayer H, Bollag W, Hänni R, Rüegg R (1978) Retinoids, a new class of compounds with prophylactic and therapeutic activities in oncology and dermatology. Experientia 34: 1105–1119PubMedCrossRefGoogle Scholar
  13. 13.
    Orfanos C, Schuppli R (1978) Workshop “Oral retinoids in dermatology”. Dermatologica 157 ( Suppl. I): 1–64Google Scholar
  14. 14.
    Ott F, Bollag W (1975) Therapie der Psoriasis mit einem oral wirksamen neuen Vitamin A-Säure-Derivat. Schweiz med Wochenschr 105: 439–441PubMedGoogle Scholar
  15. 15.
    Peck GL, Olsen TG, Yoder FW, Strauss JS, Downing DT, Pandya M, Butkus D, ArnaudBattandier J (1979) Prolonged remissions of cystic and conglobate acne with 13-cis retinoic acid. N Engl J Med 300: 329–333PubMedCrossRefGoogle Scholar
  16. 16.
    Plewig G, Wolff HH, Braun-Falco O (1971) Lokalbehandlung normaler und pathologischer menschlicher Haut mit Vitamin A-Säure. Arch Klin Exp Derm 239: 1547–1551CrossRefGoogle Scholar
  17. 17.
    Scherrer A, Ótt F (1976) Die Lokaltherapie der Akne vulgaris mit einem aromatischen Retinoid. Praxis 65: 453–455PubMedGoogle Scholar
  18. 18.
    Schumacher A, Stüttgen G (1971) Vitamin A-Säure bei Hyperkeratosen, epithelialen Tumoren und Akne. Dtsch med Wochenschr 96: 1547–1551PubMedCrossRefGoogle Scholar
  19. 19.
    Sporn MB, Newton DL (1979) Chemoprevention of cancer with retinoids. Fed Proc 38: 2528–2534PubMedGoogle Scholar
  20. 20.
    Stüttgen G (1962) Zur Lokalbehandlung von Keratosen mit Vitamin A-Säure. Dermatologica 124: 65–80CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1981

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  • W. Bollag

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