Abstract
Retinoic acid (RA) is a potent stimulator of epidermal DNA synthesis and mitosis in vivo and in vitro (2–4, 8). In vivo repeated application of RA leads to epidermal hyperplasia, which shows psoriasiform changes in the guinea pig ear (2, 8). In vitro the presence of RA in the culture medium increases the attachment of epidermal cells and causes rapid expansion and growth of the cell cultures (3).
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© 1981 Springer-Verlag
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Pohl, J., Christophers, E. (1981). Mitogenic Properties of Aromatic Retinoids: in vivo and in vitro Effects on Epidermal Cells. In: Orfanos, C.E., Braun-Falco, O., Farber, E.M., Grupper, C., Polano, M.K., Schuppli, R. (eds) Retinoids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68023-6_17
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DOI: https://doi.org/10.1007/978-3-642-68023-6_17
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