Abstract
Objective responses to leukocyte Interferon have now been demonstrated in acute lymphoblastic leukaemia (Hill et al. 1980), chronic lymphocytic leukaemia (Gutterman et al. 1979), myeloma (Meilsted et al. 1979; Idestrom et al. 1979; Osserman and Sherman 1980) and non-Hodgkin’s lymphoma (NHL) (Gutterman et al. 1979; Merigan et al. 1978). In 1977 Balkwill and Oliver demonstrated an in vitro cytostatic effect on myeloblasts using human lymphoblastoid interferon (HLBI) (Balkwill and Oliver 1977). This prompted us to undertake a Phase I study of HLBI in patients with acute myeloblastic leukaemia (AML), which is currently in progress. The preliminary results form the basis of this report.
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References
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© 1981 Springer-Verlag Berlin Heidelberg
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Rohatiner, A., Balkwill, F., Malpas, J.S., Lister, T.A. (1981). A Phase I Study of Human Lymphoblastoid Interferon in Patients with Hematological Malignancies. In: Neth, R., Gallo, R.C., Graf, T., Mannweiler, K., Winkler, K. (eds) Modern Trends in Human Leukemia IV. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67984-1_9
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DOI: https://doi.org/10.1007/978-3-642-67984-1_9
Publisher Name: Springer, Berlin, Heidelberg
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