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Generation of Stable Antigen Loss Variants from Cloned Tumor Lines—An Example of Immunoadaptation During Metastasis

  • V. Schirrmacher
  • K. Bosslet
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 26)

Abstract

The experiments to be presented will demonstrate a new type of tumor variant which can arise with high frequency within carefully cloned tumor cell lines. As a possible mechanisms of escape from a T cell mediated antitumor immune response, the tumor cells studied reduce the expression of the tumor antigen and pass this new antigen negative phenotype on to many subsequent cell generations. These findings are interpreted as an example of adaptation of tumor cells to their microenvironment. The relevance of this finding for tumor metastasis will be discussed.

Keywords

Tumor Antigen Tumor Line Antigen Negative Tumor Tumor Antigen Positive Cell Subsequent Cell Generation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bosslet K, Schirrmacher V (to be published) Clonal tumor cell variants arising by adaptation. Proceedings of EORTC Metastasis Conference, London, 1980Google Scholar
  2. Bosslet K, Schirrmacher V, Shantz G (1979) Tumor metastase and cell-mediated immunity in a modl system in DBA/2 mice. VI. Similar specificity patterns of protective anti-tumor immunity in vivo and of cytolytic T cells in vitro. Int J Cancer 24:303–313PubMedCrossRefGoogle Scholar
  3. Schirrmacher V (1980) Commentary. Shifts in tumor cell phenotypes induced by signals from the microenvironment. Relevance for the immunobiology of cancer metastasis. Immunobiology 157:89–98PubMedCrossRefGoogle Scholar
  4. Schirrmacher V, Bosslet K (1980) Tumor metastases and cell-mediated immunity in a model system in DBA/2 mice. X. Immunoselection of tumor variants differing in tumor antigen expression and metastatic capacity. Int J Cancer 25:781–788PubMedCrossRefGoogle Scholar
  5. Schirrmacher V, Shantz G, Clauer K, Komitowski D, Zimmermann H-P, Lohmann-Matthes ML (1979a) Tumor metastases and cell-mediated immunity in a model system in DBA/2 mice. I. Tumor invasiveness in vitro and metastases formation in vivo. Int J Cancer 23:233–244PubMedCrossRefGoogle Scholar
  6. Schirrmacher V, Bosslet K, Shantz G, Clauer K, Hübsch D (1979b) Tumor metastases and cell-mediated immunity in a model system in DBA/2 mice. IV. Antigenic differences between the parental tumor line and its metastasizing variant. Int J Cancer 23:245–252PubMedCrossRefGoogle Scholar
  7. Schirrmacher V, Cheingsong-Popov, R, Arnheiter H (1980) Hepatocyte-tumor cell interaction in vitro. I. Conditions for rosette formation and inhibition by anti-H-2 antibody. J Exp Med 151:984–989PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • V. Schirrmacher
  • K. Bosslet

There are no affiliations available

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