Generation of Stable Antigen Loss Variants from Cloned Tumor Lines—An Example of Immunoadaptation During Metastasis
The experiments to be presented will demonstrate a new type of tumor variant which can arise with high frequency within carefully cloned tumor cell lines. As a possible mechanisms of escape from a T cell mediated antitumor immune response, the tumor cells studied reduce the expression of the tumor antigen and pass this new antigen negative phenotype on to many subsequent cell generations. These findings are interpreted as an example of adaptation of tumor cells to their microenvironment. The relevance of this finding for tumor metastasis will be discussed.
KeywordsTumor Antigen Tumor Line Antigen Negative Tumor Tumor Antigen Positive Cell Subsequent Cell Generation
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- Bosslet K, Schirrmacher V (to be published) Clonal tumor cell variants arising by adaptation. Proceedings of EORTC Metastasis Conference, London, 1980Google Scholar