Pancreatic Extracts in Chronic Pancreatitis: Which, How and When?

  • G. Dobrilla
  • M. Felder
  • G. de Pretis
Conference paper


The primary function of the exocrine pancreas is the secretion of amylolytic, lipolytic, and proteolytic enzymes into the duodenum in response to the alimentary stimulus. The almost instinctive tendency to administer pancreatic enzymes to patients with pancreatic disease and secondary functional insufficiency is therefore not surprising, so that enzymatic activity in the small intestine can remain sufficient to prevent and/or to treat maldigestion of foods. However, although an oral enzyme replacement of this kind has for quite a long time been available, many reviews [1–4] have pointed out the lack of a rational therapy based on sound physiologic measurements. This explains the existence of numerous pharmacologic preparations, different dosages used, frequent variability of their administration, and the difference in clinical results obtained. Even authoritative textbooks, both of pharmacology and gastroenterology [5, 6], do not prove to be entirely pertinent, thus confirming how slow they are to assimilate data deriving from new scientific developments or from the controlled clinical trials [7]. It is in the light of this recent information that in the following paragraphs we shall discuss which enzymatic preparations are suitable for use, and how and when to administer them.


Cystic Fibrosis Chronic Pancreatitis Pancreatic Enzyme Pancreatic Insufficiency Pancreatic Exocrine Insufficiency 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • G. Dobrilla
    • 1
  • M. Felder
    • 1
  • G. de Pretis
    • 1
  1. 1.Divisione di GastroenterologiaOspedale Generale Regionale di BolzanoBolzanoItaly

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