Advertisement

Systematik der Non-Hodgkin-Lymphome

  • H. Stein
Part of the Handbuch der Inneren Medizin book series (INNEREN, volume 2 / 7)

Zusammenfassung

Die Bemühungen um eine Systematik der malignen Non-Hodgkin-Lymphome basierten in der Vergangenheit ausschließlich auf dem Versuch einer morphologischen Charakterisierung der Tumorzellen. Diese Entwicklung hat mit der von Rappaport (1966) vorgestellten Klassifikation ihren Abschluß gefunden. Denn ab Anfang der siebziger Jahre wurden in zunehmendem Maße funktionelle und immunologische Kriterien zur Charakterisierung neoplastischer lymphatischer Zellen herangezogen. Die folgende kurze Zusammenstellung einiger wichtiger Daten zur Geschichte der Lymphomklassifikation soll den Weg von den Anfängen bis in die Gegenwart beleuchten und dazu beitragen, die bisherige Verwirrung auf dem Gebiete der Systematik der Non-Hodgkin-Lymphome einerseits zu verstehen und andererseits zu beseitigen.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Aisenberg, A.C., Bloch, K.J.: Immunglobulins on the surface of neoplastic lymphocytes. New Engl. J. Med. 287, 272 (1972).PubMedCrossRefGoogle Scholar
  2. Alibert: Monographie des dermatoses. Paris 1832.Google Scholar
  3. Azar, H.A.: Pathology of multiple myeloma and related growths. In: Multiple myeloma and related disorders (H.A. Azar, M. Potter, Eds.), Vol. I, pp. 1–85. New York: Harper & Row 1973.Google Scholar
  4. Basten, A., Warner, N.L., Mandel, T.: A receptor for antibody on B lymphocytes. II. Immunochemical and electron microscopy characteristics. J. exp. Med. 135, 627 (1972).PubMedCrossRefGoogle Scholar
  5. Bennet, M.H., Millett, Y.L.: Nodular siderotic lymphosarcoma: a possible new clinico pathological entity. Clin. Radiol. 20, 339 (1969).CrossRefGoogle Scholar
  6. Bennett, M.H., Farrer-Brown, G., Henry, K., Jelliffe, A.M.: Classification of non-Hodgkin’s lymphomas. Lancet 1974 II, 405.CrossRefGoogle Scholar
  7. Berard, C.W., Dorfman, R.F.: Histopathology of malignant lymphomas. Clin. Hemat. 3, 39 (1974).Google Scholar
  8. Bessis, M.C.: Ultrastructure of lymphoid and plasma cells in relation to globulin and antibody formation. Lab. Invest. 10, 1040 (1961).PubMedGoogle Scholar
  9. Bianco, D., Patrick, R., Nussenzweig, V.: A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. J. exp. Med. 132, 702 (1970).PubMedCrossRefGoogle Scholar
  10. Billroth, T.: Multiple Lymphome. Erfolgreiche Behandlung mit Arsenik. Wien. med. Wschr. 21, 1065(1871).Google Scholar
  11. Bornkamm, G.W., Stein, H., Lennert, K., Stein, H., Rüggeberg, Bartels, H., Zur Hausen, H.: Attempts to demonstrate virusspecific sequences in human tumors? IV. EB Viral DNA in European Burkitt’s Lymphoma and Immunoblastic Lymphadenopathy. Int. J. Cancer 17, 177 (1976).PubMedCrossRefGoogle Scholar
  12. Bouroncle, B.A., Wiseman, B.K., Doan, C.A.: Leukemic reticuloendotheliosis. Blood 13, 609 (1958).PubMedGoogle Scholar
  13. Braylan, R.C., Jaffe, E.S., Mann, R.B., Frank, M.M., Berard, C.W.: Surface receptors of human neoplastic lymphoreticular cells. In: Immunological diagnosis of leukemias and lymphomas. Haematology and blood transfusion (Thierfelder, S., Rodt, H., Thiel, E., Eds.), Vol. 20, pp. 47–52. Berlin-Heidelberg-New York: Springer 1977.CrossRefGoogle Scholar
  14. Brill, N.E., Baehr, G., Rosenthal, N.: Generalized giant lymph follicle hyperplasia of lymph nodes and spleen. A hitherto undescribed type. J. Amer. med. Assoc. 84, 668 (1925).Google Scholar
  15. Broder, S., Edelson, R.L., Lutzner, M.A., Nelson, D.L., MacDermott, R.P., Durm, M.E., Goldman, CK., Meade, B.D., Waldmann, T.A.: The Sézary syndrome. A malignant proliferation of helper T cells. J. clin. Invest. 58, 1297–1306 (1976).PubMedCrossRefGoogle Scholar
  16. Brouet, J.C., Preud’Homme, J.L., Seligmann, M.: The use of B and T membrane markers in the classification of leukemias, with special references to acute lymphoblastic leukemia. Blood Cells 1, 81 (1975).Google Scholar
  17. Brouet, J.C., Preud’Homme, J.L., Flandrin, G., Chelloul, N., Seligmann, M.: Membrane markers in ‘histiocytic’ lymphomas (reticulum cell sarcomas). J. nat. Cancer Inst. 56, 631–633 (1976).PubMedGoogle Scholar
  18. Burkitt, D.: A sarcoma involving the jaws in african children. Brit. J. Surg. 46, 218 (1958).PubMedCrossRefGoogle Scholar
  19. Burns, G.F., Cawley, J.C., Barker, C.R., Hayhoe, G.J.: Absence of a receptor for fixed C3 on the hairy cells of leukemic reticuloendotheliosis. Clin. exp. Immunol. 29, 442 (1977).PubMedGoogle Scholar
  20. Buskard, N.: Prolymphocytic leukemia. Gemeinsame Tagung der Deutschen und Österreichischen Gesellschaft für Hämatologie Bad Nauheim, September 1975.Google Scholar
  21. Buskard, N.A., Catovsky, D., Okos, A., Goldman, J.M., Galton, D.A.G.: Prolymphocytic leukaemia: Cell studies and treatment by leucapheresis. In: Maligne Lymphome und monoklonale Gammopathien. Hämatologie und Bluttransfusion (Löffler, H., Ed.), Bd. 18, pp. 237–253. München: Lehmanns 1976.Google Scholar
  22. Byrne, Jr., E., Rappaport, H.: Malignant histiocytosis: In: Malignant diseases of the hematopoietic system. GANN Monograph on Cancer Research (Akazaki, K., Rappaport, H., Berard, C.W., Bennett, J.M., Ishikawa, E., Eds.), Vol. 15, pp. 145–162. Tokyo: University of Tokyo Press 1973.Google Scholar
  23. Callender, G.R.: Tumors and tumor-like conditions of the lymphocyte, the myelocyte, the erythrocyte and reticulum cell. Amer. J. Path. 10, 443 (1934).PubMedGoogle Scholar
  24. Catovsky, D., Galetto, J., Okos, A., Miliani, E., Galton, D.A.G.: Cytochemical profile of B and T leukaemic lymphocytes with special reference to acute lymphoblastic leukaemia. J. clin. Path. 27, 767 (1974).PubMedCrossRefGoogle Scholar
  25. Catovsky, D., Pettit, J.E., Galetto, J., Okos, A., Galton, D.A.G.: The B-lymphocyte nature of the hairy cell of leukemic reticuloendotheliosis. Brit. J. Haemat. 26, 29 (1974).PubMedCrossRefGoogle Scholar
  26. Catovsky, D., Cherchi, M., Hedge, K., Okos, A.: Mouse red cell rosettes in lymphoproliferative disorders. International Society of Haematology. European and African Division. Third Meeting London, August 1975.Google Scholar
  27. Catovsky, D., Papamichail, M., Okos, A., Miliani, E., Holborow, E.J.: Formation of mouse red cell rosettes by “hairy” cells. Biomedicine 23, 81–84 (1975).PubMedGoogle Scholar
  28. Cawley, J.C., Barker, C.R., Britchford, R.D., Smith, J.L.: Intracellular IgA immunoglobulin crystals in chronic lymphocytic leukemia. Clin. exp. Immunol. 13, 407 (1973).PubMedGoogle Scholar
  29. Dameshek, W.: “Immunoblasts” and “immunocytes” — an attempt at a functional nomenclature. Blood 21, 243–345(1963).PubMedGoogle Scholar
  30. Dameshek, W., Gunz, F.: Leukemia, second Ed. New York, London: Grune and Stratton 1964.Google Scholar
  31. DeMan, J.C.H., Meiners, W.B.H.: Criystals of protein nature in the cytoplasm of lymphatic cells in a case of lymphoreticular malignancy. Blood 20, 492 (1962).Google Scholar
  32. Dickler, H.B., Siegal, F.P., Bentwich, Z.H., Kunkel, H.G.: Lymphocyte binding of aggregated IgG and surface Ig staining in chronic lymphocytic leukemia. Clin. exp. Immunol. 14, 97 (1973).PubMedGoogle Scholar
  33. Dorfman, R.F.: Enzyme histochemistry of normal hyperplastic and neoplastic lymphoreticular tissue. Symp. Lymph. Tumors in Africa, Paris, 1963, pp. 304–326. Basel-New York: Karger 1964.Google Scholar
  34. Dorfman, R.F.: Classification of non-Hodgkin’s lymphomas. Lancet 1974 II, 961.CrossRefGoogle Scholar
  35. Drescher, J., Leder, L.D.: Zur Frage der akuten, extrem unreifzelligen Erythrämie. Z. Kinderheilk. 108, 117(1970).PubMedCrossRefGoogle Scholar
  36. Dutcher, T.F., Fahey, J.L.: The histopathology of the macroglobulinemia of Waldenström. J. nat. Cancer Inst. 22, 887 (1959).PubMedGoogle Scholar
  37. Dutcher, T.F., Fahey, J.L.: Immunocytochemical demonstration of intranuclear localisation of 18 S gamma macroglobulin in macroglobulinemia of Waldenstrom. Proc. Soc. exper. Biol. (N.Y.) 103, 452(1960).Google Scholar
  38. Edelson, R.L., Lutzner, M.A., Kirkpatrick, C.H., Shevach, E.M., Green, I.: Morphologic and functional properties of the atypical T lymphocyte of the Sezary Syndrome. Proc. Mayo Clin. 49, 558 (1974).PubMedGoogle Scholar
  39. Epstein, M.A., Achong, B.G., Barr, Y.M.: Virus particles in cultures lymphoblasts from Burkitt’s lymphoma. Lancet 1964 I, 702.CrossRefGoogle Scholar
  40. Ewald, O.: Die leukämische Reticuloendotheliose. Dtsch. Arch. klin. Med. 142, 222 (1923).Google Scholar
  41. Fagraeus, A.: Antibody production in relation to the development of plasma cells. Acta med. scand. Suppl. 204 (to Vol. 130), 1 (1948).Google Scholar
  42. Flandren, G., Brouet, J.C.: The Sezary cell: Cytologic, cytochemical and immunologic studies. Proc. Mayo Clin. 49, 575 (1974).Google Scholar
  43. Flandren, G., Daniel, M.T., El Yafi, G., Chelloul, N.: Sarcomatoses ganglionnaires diffuses à différenciation plasmocytaire avec anémie hémolytique auto-immune. Act. Hémat. 6, 25 (1972).Google Scholar
  44. Flandrin, G., Daniel, M.T., Fourcade, M., Chelloul: Leucémie a “tricholeucocyte” (hairy cell leukemia), étude clinique et cytologique de 55 observations. Nouv. Rev. franç. Hémat. 13, 609 (1973).PubMedGoogle Scholar
  45. Flemming, W.: Studien über Regeneration der Gewebe. Arch. mikr. Anat. 24, 50 (1885).CrossRefGoogle Scholar
  46. Frizzera, G., Moran, E.M., Rappaport, H.: Angio-immunoblastic lymphadenopathy with dysproteinaemia. Lancet 1974 I, 1070.Google Scholar
  47. Fröland, S.S., Natvig, J.B.: Identification of three different human lymphocyte populations by surface markers. Transplant. Rev. 16, 114 (1973).PubMedGoogle Scholar
  48. Fu, S.M., Winchester, R.J., Kunkel, H.G.: Similar idiotypic specificity for the membrane IgD and IgM of human B lymphocytes. J. Immunol. 114, 250–252 (1975).PubMedGoogle Scholar
  49. Gall, E.A., Morrison, H.R., Scott, A.T.: The follicular type of malignant lymphoma; a survey of 63 cases. Ann. intern. Med. 14, 2073 (1941).Google Scholar
  50. Galton, D.A.G., Goldmann, J.M., Wiltshaw, E., Catovsky, D., Henry, K., Goldenberg, G.: Prolymphocytic leukaemia. Br. J. Haemat. 27, 7 (1974).CrossRefGoogle Scholar
  51. Gérard-Marchant, R., Hamlin, I., Lennert, K., Rilke, F., Stansfeld, A.G., van Unnik, J.A.M.: Classification and Non-Hodgkin’s lymphomas (Letter to the Editor). Lancet 1974 II, 406–408.Google Scholar
  52. Gleichmann, E., Elven, F. Van, Gleichmann, H.: Immunoblastic lymphadenopathy, systemic lupus erythematosus, and related disorders. Possible pathogenetic pathways. Amer. J. clin. Path. 72, 708 (1979).Google Scholar
  53. Goos, M., Kaiserling, E., Lennert, K.: Mycosis fungoides: Model for T-lymphocyte homing to the skin. Brit. J. Derm. 94, 221 (1976).PubMedCrossRefGoogle Scholar
  54. Greaves, M.F., Brown, F.G., Capellaro, C., Revesz, R., Lister, A., Kapson, U.: Cell surface markers of leukemic cells. Third International Meeting of the European and African Division of the International Society of Haematology, London, August 24–28, 1975.Google Scholar
  55. Greaves, M.F., Janossy, G., Roberts, M., Rapson, N.T., Ellis, R.B., Chessels, J., Lister, T.A., Catovsky, D.: Membrane phenotyping: Diagnosis, monitoring and classification of acute ‘lymphoid’ leukaemias. In: Immunological diagnosis of leukemias and lymphomas. Haematology and blood transfusion (Thierfelder, S., Rodt, H., Thiel, E., Eds.), Vol. 20, pp. 61–74, Berlin-Heidelberg-New York: Springer 1977.CrossRefGoogle Scholar
  56. Grey, H.M., Rabellino, E., Pirofsky, B.: Immunglobulins on the surface of lymphocytes. IV. Distribution in hypo-gamma-globulinaemia, cellular immune deficiency, and chronic lymphatic leukemia. J. clin. Invest. 50, 2375 (1971).CrossRefGoogle Scholar
  57. Grossi, CE., Webb, S.R., Zicca, A., Lydyard, P.M., Moretta, L., Mingari, M.C., Cooper, M.D.: Morphological and histochemical analyses of two human T-cell subpopulations bearing receptors for IgM or IgG. J. exp. Med. 147, 1405–1417 (1978).PubMedCrossRefGoogle Scholar
  58. Henry, K.: Electron microscopy in the non-Hodgkin’s lymphomata. Brit. J. Cancer 31, Suppl. II, 73–93 (1975)Google Scholar
  59. Heyden, H.W.v, Rieber, E.P., Waller, H.D., Riethmüller, G.: Funktionelle Charakteristika von Haarzellen. Gemeinsame Tagung der Deutschen und der Österreichischen Gesellschaft für Hämatologie, Bad Nauheim, September 1975.Google Scholar
  60. Hodgkin, T.: On some morbid appearances of the absorbent glands and spleen. Medico-chirurgical Transactions 17, 68 (1832).PubMedGoogle Scholar
  61. Hurez, D., Flandrin, G., Preud’Homme, J.L., Seligmann, M.: Unreleased intracellular monoclonal macroglobulin in chronic lymphocytic leukemia. Clin. exp. Immunol. 10, 223 (1972).PubMedGoogle Scholar
  62. Jaffé, E.S., Shevach, E.M., Frank, M.M., Berard, C.W., Green, I.: Nodular lymphoma-evidence for origin from follicular B-lymphocytes. New Engl. J. Med. 290, 813 (1974).PubMedCrossRefGoogle Scholar
  63. Jondal, M., Holm, G., Wigzell, H.: Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune resettes with sheep red blood cells. J. exp. Med. 136, 207 (1972).PubMedCrossRefGoogle Scholar
  64. Jones, S.E., Fuks, Z., Bull, M., Kadin, M.E., Dorfman, R.F., Kaplan, H.S., Rosenberg, S.A., Kim, H.: Non-Hodgkin’s lymphomas. IV. Clinicopathologic correlation in 405 cases. Cancer (Philad.) 31, 806 (1973).PubMedCrossRefGoogle Scholar
  65. Jones, D.B., Castleden, M., Smith, J.L., Mepham, B.L., Wright, D.H.: Immunopathology of angioimmunoblastic lymphadenopathy. Brit. J. Cancer 37, 1053 (1978).PubMedCrossRefGoogle Scholar
  66. Kaiserling, E.: Elektronenmikroskopische Befunde bei Non-Hodgkin-Lymphomen. In: Hämatologie und Bluttransfusion, Bd. 18, S. 185–198. München: Lehmanns 1976.Google Scholar
  67. Kaiserling, E., Lennert, K.: Die interdigitierende Reticulumzelle im menschlichen Lymphknoten. Eine spezifische Zelle der thymusabhängigen Region. Virchows Arch. B 16, 51–61 (1974).Google Scholar
  68. Kaiserling, E., Stein, H., Müller-Hermelink, H.K.: Interdigitating reticulum cells in the human thymus. Cell Tiss. Res. 155, 47–55 (1974).CrossRefGoogle Scholar
  69. Kanzow, U., Oettgen, H.: Beitrag zur Morphologie der Makroglobulinämie Waldenström. Acta haemat. (Basel) 15, 323 (1956).PubMedCrossRefGoogle Scholar
  70. Katayama, I., Li, C.Y., Yam, L.T.: Ultrastructural characteristics of the “Hairy Cells” of leukemic reticuloendotheliosis. Amer. J. Path. 67, 361 (1972).PubMedGoogle Scholar
  71. Klein, E., Klein, G., Nadkarni, J.S., Nadkarni, J.J., Wigzell, H., Clifford, P.: Surface IgM specifity on cells derived from a Burkitt’s lymphoma, Lancet 1967 II, 1068.CrossRefGoogle Scholar
  72. Krüger, G., O’Connor, G.T.: Epidemiologic and immunologic conserations on the pathogenesis of Burkitt’s tumor. In: Recent results in cancer research (E. Grundmann, H. Tulinius, Eds.), Vol. 39, p. 212. Berlin-Heidelberg-New York: Springer 1972.Google Scholar
  73. Kubo, R.T., Grey, H.M., Pirofsky, B.: IgD: A major immunoglobulin on the surface of lymphocytes from patients with chronic lymphatic leukemia. J. Immunol. 112, 1952–1954 (1974).PubMedGoogle Scholar
  74. Kundrat, H.: Über Lympho-Sarkomatosis. Wien. klin. Wschr. 6, 211, 234–239 (1893).Google Scholar
  75. Laszlo, J., Gerber, H.G., Sommer, J.R.: Composition and structure of cytoplasmic globules in leukemic lymphocytes. Blood 29, 77 (1967).PubMedGoogle Scholar
  76. Leder, L.-D.: Fermenthistochemische Befunde bei chronischer Erythroblastose und akuter Erythrämie. Klin. Wschr. 43, 795 (1965).PubMedCrossRefGoogle Scholar
  77. Leder, L.-D.: Der Blutmonocyt. Berlin-Heidelberg-New York: Springer 1967.Google Scholar
  78. Leder, L.-D.: Zur Praxis der bioptischen Hämoblastosediagnostik mit zytochemischen Methoden. Beitr. Path. 141, 396 (1970).Google Scholar
  79. Leeuwen, A.W.F.M. van, Meijer, C.J.L.M., de Man, J.C.H.: T-cell membrane characteristics of “mycosis cells” in the skin and lymph node. J. invest. Derm. 65, 367 (1975).PubMedCrossRefGoogle Scholar
  80. Lelbach, W.K.: Ein Beitrag zur Morphologie der Makroglobulinämie Waldenström. Frankf. Z. Path. 68, 440 (1957).Google Scholar
  81. Lennert, K.: Die pathologische Anatomie der Makroglobulinämie Waldenström. Frankf. Z. Path. 66, 201 (1955).Google Scholar
  82. Lennert, K.: Pathologie der Halslymphknoten. Ein Abriß für Pathologen, Kliniker und praktizierende Ärzte. Berlin-Göttingen-Heidelberg-New York. Springer 1964.Google Scholar
  83. Lennert, K.: Classification of malignant lymphomas (European Conzept). In: Progress in lymphology (A. Röttmann, Ed.). Stuttgart: Thieme 1968.Google Scholar
  84. Lennert, K.: Pathologisch-histologische Klassifizierung der malignen Lymphome. In: Leukämien und maligne Lymphome(A. Stacher, Ed.). München-Berlin-Wien: Urban & Schwarzenberg 1973.Google Scholar
  85. Lennert, K.: Follicular lymphoma. A tumor of the germinal centers. Gann Monograph on Cancer Research 15, 217 (1973).Google Scholar
  86. Lennert, K.: Origin of malignant lymphomas. Lancet 1974 II, 586.CrossRefGoogle Scholar
  87. Lennert, K.: Lymphom-Tutorial. International Academy of Pathology, Damp/Ostsee, Nov. 1975.Google Scholar
  88. Lennert, K., Niedorf, H.R.: Nachweis von desmosal verknüpften Reticulumzellen im follikulären Lymphom (Brill-Symmers). Virchows Arch. Abt. B. Zellpath. 4, 148 (1969).Google Scholar
  89. Lennert, K., Stein, H., Kaiserling, E.: Cytological and functional criteria for the classification of malignant lymphomata. Brit. J. Cancer 31, Suppl. II, 29 (1975).Google Scholar
  90. Lennert, K., Kaiserling, E., Müller-Hermelink, H.K.: T-associated plasma-cells. Lancet 1975 I, 1031.CrossRefGoogle Scholar
  91. Lennert, K.: Malignant lymphomas other than Hodgkin’s disease. In: Handbuch der speziellen pathologischen Anatomie und Histologie (Uehlinger, E., Ed.), Bd. 1/3 B. Berlin-Heidelberg-New York: Springer 1978.Google Scholar
  92. Löffler, H.: Zur Differenzierung unreifzelliger (akuter) Leukosen mit cytochemischen Methoden. Folia Haemat. (Frankfurt) N.F. 8, 112 (1963).Google Scholar
  93. Löffler, H., Meyhofer, W., Lange, R.H., Ehlers, G., Remmele, W.: Sézary-Syndrom – eine leukämische Variante der Mykosis fungoides. Dtsch. med. Wschr. 99, 429 (1974).PubMedCrossRefGoogle Scholar
  94. Lukes, R.J.: Slide seminar: Malignant lymphoma. 10th International Congress of the International Academy of Pathology. Hamburg, September 16 (1974).Google Scholar
  95. Lukes, R.J., Collins, R.D.: New approaches to the classification of the lymphomata. Br. J. Cancer 31, Suppl. II, 1 (1975).CrossRefGoogle Scholar
  96. Lukes, R.J., Collins, R.D.: A functional approach to the classification of malignant lymphoma. In: Recent Results in Cancer Research: Diagnosis and therapy of malignant lymphoma (Musshoff, K., Ed.), p. 18. Berlin-Heidelberg-New York: Springer 1975.Google Scholar
  97. Lukes, R.J., Tindle, B.J.: Immunoblastic lymphoadenopathie. A hyperimmune entity resembling Hodgkin’s disease. New Engl. J. Med. 292, 1 (1975).PubMedCrossRefGoogle Scholar
  98. Lutzner, M.A., Emerit, I., Durepaire, R., et al.: Cytogenetic, cytophotometric, and ultrastructural study of large ceribriform cells of the Sezary syndrome and description of a small-cell variant. J. nat. Cancer Inst. 50, 1145 (1973).PubMedGoogle Scholar
  99. Marmont, A.M., Damasio, E.E.: B Lymphocytes in macroglobulinemia. Lancet 1971 II, 1326.CrossRefGoogle Scholar
  100. Marschalko, T.U.: Über die sog. Plasmazellen. Arch. Derm. (Lpz.) 30, 3 (1895).CrossRefGoogle Scholar
  101. Mathé, G., Belpomme, D., Dantchev, D., Pouillart, P.: Progress in the Classification of lymphoid and/or monocytoid Leukemias and of lympho- and reticulo sarcomas (Nond-Hodgkin’s lymphomas). Biomedicine 22, 177 (1975).PubMedGoogle Scholar
  102. McCaffrey, R., Harrison, T.A., Kung, P.C., Parkman, R., Sil verstone, A.E. Baltimore, D.: Terminal deoxynucleotidyl transferase in normal and neoplastic hematopoietic cells. In: Modern Trends in human leukemia II. Hämatologie und Bluttransfusion. (Neth, R., Gallo, R.C., Mannweiler, K., Moloney, W.C., Eds.), Bd. 19, pp. 503–513, München: Lehmanns 1976.Google Scholar
  103. Melchers, F., Cone, R.E., von Boehmer, Sprent, J.: Immunoglobulin turnover in B lymphocyte subpopulation. Europ. J. Immunol. 5, 382 (1975).CrossRefGoogle Scholar
  104. Milanesi, S.: Sulla presenza di dispositivi di giunzione tra le cellule dendritiche dei follicoli linfatici de linfonodo. Boll. Soc. ital. Biol. Sper. 41, 1223–1225 (1965).Google Scholar
  105. Mitchell, J., Abbot, A.: Ultrastructure of the antigen-retaining reticulum of lymph node follicles as shown by high-resolution autoradiography. Nature (Lond.) 208, 500–502 (1965).PubMedCrossRefGoogle Scholar
  106. Mitus, W.J., Mednicoff, I.B., Wittels, B., Dameshek, W.: Neoplastic lymphoid reticulum cells in the peripheral blood: A histochemical study. Blood 17, 206 (1961).PubMedGoogle Scholar
  107. Morris, M.W., Davey, F.R.: Immunologic and cytochemical properties of histiocytic and mixed histiocytic-lymphocytic lymphomas. Amer. J. clin. Path. 63, 403–414 (1975).Google Scholar
  108. Neiman, R.S., Dervan, P., Haudenschild, C., Jaffe, R.: Angioimmunoblastic lymphadenopathy. An ultrastructural and immunologic study with review of the literature. Cancer 41, 507 (1978).PubMedCrossRefGoogle Scholar
  109. Nieuwenhuis, P., van Nouhuijs, C.E., Eggens, J.H., Keuning, F.J.: Germinal centres and the origin of the B-cell system. I. Germinal centres in the rabbit appendix. Immunology 26, 497 (1974).PubMedGoogle Scholar
  110. Nossal, G.J.V., Abbot, A., Mitchell, J., Lummus, Z.: Antigens in immunity. XV. Ultrastructural features of antigen capture in primary and secondary lymphoid follicles. J. exp. Med. 127, 277–290 (1968).PubMedCrossRefGoogle Scholar
  111. O’Connor, G.T.: Persistent immunologic stimulation as a factor in oncogenesis, with special reference to Burkitt’s tumor. Amer. J. Med. 48, 279 (1970).PubMedCrossRefGoogle Scholar
  112. Oettgen, H.F., Quitmann, K.: Weitere Untersuchungen zur Morphologie der Makroglobulinämie Waldenstrom. Frankf. Z. Path. 67, 599 (1956).Google Scholar
  113. Osserman, E.F., Takatsuki, K.: Plasmacell myeloma: Gamma globulin synthesis and structure! A review of biochemical and clinical data, with the discription of a newly — recognized and related syndrome, “H- gamma- 2-chain” (Franklin’s) disease. Medicine (Baltimore) 42, 357 (1963).PubMedCrossRefGoogle Scholar
  114. Paltauf, R.: Lymphosarkom. Ergebn. allg. Path. Anat. 3, 652 (1896).Google Scholar
  115. Parkhouse, R.M.E., Askonas, B.A.: Immunoglobulin M biosynthesis. Intracellular accumulation of 7 S subunits. Biochem. J. 115, 163 (1969).PubMedGoogle Scholar
  116. Perms, B., Form, L., Amante, L.: Immunoglobulins. Ann. N.Y. Acad. Sci. 190, 420 (1971).CrossRefGoogle Scholar
  117. Plenderleit, I.H.: Hairy cell leukemia. Canad. med. Ass. J. 102, 1056 (1970).Google Scholar
  118. Preud’Homme, J.L., Seligmann, C.M.: Surface bound immunoglobulins as a marker in human lymphoproliferative disease. Blood 40, 777 (1972).PubMedGoogle Scholar
  119. Preud’Homme, J.-L., Seligmann, M.: Immunoglobulins on the surface of lymphoid cells in Waldenstrom’s macroglobulinemia. J. clin. Invest. 51, 701 (1972).PubMedCrossRefGoogle Scholar
  120. Preud’Homme, J.L., Brouet, J.C., Clauvel, J.P., Seligmann, M.: Surface IgD in immunoproliferative disorders. Scand. J. Immunol. 3, 853–858 (1974).PubMedCrossRefGoogle Scholar
  121. Radaszkiewicz, T., Lennert, K.: Lymphogranulomatosis X. Klinisches Bild, Therapie und Prognose. Dtsch. med. Wschr. 100, 1157 (1975).PubMedCrossRefGoogle Scholar
  122. Raff, M.C.: Two distinct populations of peripheral lymphocytes in mice distinguishable by immunofluorescence. Immunology 19, 637 (1970).PubMedGoogle Scholar
  123. Rappaport, H.: Atlas of tumor pathology, Sect. 3, Fasc. 8: Tumors of the hematopoietic system. Washington/D.C.: AFIP 1966.Google Scholar
  124. Rappaport, H., Johnson, F.B.: Intracellular protein resembling Russel bodies in malignant lymphomas, associated with acquired hemolytic anemia. Blood 10, 132 (1955).PubMedGoogle Scholar
  125. Rappaport, H., Winter, W.J., Hicks, E.B.: Follicular lymphoma. A reevaluation of its position in the scheme of laign lymphoma, based on a survey of 253 cases. Cancer (Philad.) 9, 792 (1956).PubMedCrossRefGoogle Scholar
  126. Reed, D.M.: On the pathological changes in Hodgkin’s disease, with especial reference to its relation to tuberculosis. Johns Hopk. Hosp. Rep. 10, 133 (1902).Google Scholar
  127. Rieber, E.P., Linke, R.P., Hadam, M., Saal, J.G., Riethmüller, G., v. Heyden, H.W., Waller, H.D., Schwarz, H.: Hairy cell leukemia: Simultaneous demonstration of autochthonous surface-Igand monocytic functions of hairy cells. In: Immunological diagnosis of leukemias and lymphomas. Haematology and blood transfusion. (Thierfelder, S., Rodt, H., Thiel, E., Eds., Vol. 20, pp. 157–161. Berlin-Heidelberg-New York: Springer 1977.CrossRefGoogle Scholar
  128. Ritter, J., Gaedicke, G., Winkler, K., Beckmann, H., Landbeck, G.: Possible T-cell origin of lymphoblasts in acid-phosphatase-positive acute lymphatic leukaemia. Lancet 1975 II, 75.CrossRefGoogle Scholar
  129. Rohr, K.: Das menschliche Knochenmark. 3. Aufl. Stuttgart: Thieme 1960.Google Scholar
  130. Ross, G.D., Polley, M.J., Rabellino, E.M.: On human lymphocytes. The specific for C3b and one specific for C3b inactivator-cleaved C3b. J. exp. Med. 138, 798 (1973).PubMedCrossRefGoogle Scholar
  131. Roulet, F.: Das primäre Retothelsarkom der Lymphknoten. Virchows Arch. path. Anat. 277, 15 (1930).CrossRefGoogle Scholar
  132. Rubin, A.D., Douglas, S.D., Chessin, L.N., Glade, P.R., Dameshek, W.: Chronic reticulolymphocytic leukemia. Reclassification of “leukemic reticuloendotheliosis” through functional characterization of the circulating mononuclear cells. Amer. J. Med. 47, 149 (1969).PubMedCrossRefGoogle Scholar
  133. Schamaun, M.: Zur pathologischen Anatomie der sog. Makroglobulinämie Waldenstrom. Schweiz. Z. allg. Path. 17, 25(1954).Google Scholar
  134. Schrek, R., Donnelly, W.J.: “Hairy” cells in blood in lymphoreticular neoplastic disease and “flagellated” cells of normal lymph nodes. Blood 27, 199 (1966).PubMedGoogle Scholar
  135. Scott, R.B., Robb-Smith, A.H.T.: Histiocytic medullary reticulosis. Lancet 1939 II, 194–198.CrossRefGoogle Scholar
  136. Seligmann, M., Brouet, J.-C., Preud’Homme, J.-L.: The immunological diagnosis of human leukemias and lymphomas: an overview. In: Immunological diagnosis of leukemias and lymphomas. Haematology and blood transfusion. (Thierfelder, S., Rodt, H., Thiel, E., Eds.), Vol. 20, pp. 1–15. Berlin-Heidelberg-New York: Springer 1977.CrossRefGoogle Scholar
  137. Sézary, A., Bouvrain, Y.: Erythrodermie avec présée de cellules monstrueuses dans le derme et le sang circulant. Bull. Soc. franc. Derm. Syph. 45, 254 (1938).Google Scholar
  138. Sherr, C.J., Uhr, J.W.: Immunoglobulin synthesis and secretion VI. Synthesis and intracellular transport of immunoglobulin in nonsecretory lymphoma cells. J. exp. Med. 133, 901 (1971).PubMedCrossRefGoogle Scholar
  139. Shevach, E.M., Herberman, R., Frank, M.M., Green, J.: Receptors for complement and immunoglobulin on human leukemic cells and human lymphoblastoid cell lines. J. clin. Invest. 51, 1933 (1972).PubMedCrossRefGoogle Scholar
  140. Shevach, E.M., Jaffe, E.S., Green, I.: Receptors for complement and immunoglobulin on human and animal lymphoid cells. Transplant. Rev. 16, 3 (1973).PubMedGoogle Scholar
  141. Stathopoulos, G., Elliot, E.V.: Formation of mouse or sheep red-blood-cell rosettes by lymphocytes from normal and leukemic individuals. Lancet 1974 I, 600.CrossRefGoogle Scholar
  142. Stein, H.: Zur Charakterisierung maligner Lymphome. Morphologische und immunologische Untersuchungen. Habilitationsschrift Kiel 1975.Google Scholar
  143. Stein, H.: Immunologische und immunchemische Techniken und ihre Bedeutung für die Klassifikation lymphatischer Neoplasien. Verh. dtsch. Ges. Path. 59, 510 (1975).Google Scholar
  144. Stein, H.: Immunchemische und immunzytologische Befunde bei Non-Hodgkin-Lymphomen. In: Hämatologie und Bluttransfusion, Bd. 18, S. 167–183. München: Lehmanns 1976.Google Scholar
  145. Stein, H.: Klassifikation der malignen Non-Hodgkin-Lymphome aufgrund gemeinsamer morphologischer und immunologischer Merkmale zwischen normalen und neoplastischen lymphatischen Zellen. Infektion und Immunität 4, 59 (1976).Google Scholar
  146. Stein, H.: Klassifikation der malignen Non-Hodgkin-Lymphome aufgrund gemeinsamer morphologischer und immunologischer Merkmale zwischen normalen und neoplastischen lymphatischen Zellen. IL Teil. Infektion und Immunität 4, 95 (1976).Google Scholar
  147. Stein, H.: The immunologic and Immunochemical basis for the Kiel classification. In: Handbuch der speziellen pathologischen Anatomie und Histologie (Uehlinger, E., Ed.), Bd. I/3 B, pp. 529–656. Berlin-Heidelberg-New York: Springer 1978.Google Scholar
  148. Stein, H., Kaiserling, E.: Surface immunoglobulins and lymphocytespecific surface antigens on leukemic reticuloendotheliosis cells. Clin. exp. Immunol. 18, 63 (1974).PubMedGoogle Scholar
  149. Stein, H., Lennert, K., Parwaresch, M.R.: Malignant lymphomas of B-cell type. Lancet 1972 II, 855CrossRefGoogle Scholar
  150. Stein, H., Kaiserling, E., Lennert, K.: Neue Gesichtspunkte zur Systematik maligner Lymphome auf dem Boden immunchemischer Analysen. In: Leukämien und maligne Lymphome (A. Stacher, Hrsg.). München-Berlin-Wien: Urban & Schwarzenberg 1973.Google Scholar
  151. Stein, H., Kaiserling, E., Lennert, K., Parwaresch, M.R.: Makroglobulinbildende chronische lymphatische Leukämie ohne Makroglobulinämie. Klin. Wschr. 51, 389 (1973).PubMedCrossRefGoogle Scholar
  152. Stein, H., Kaiserling, E., Lennert, K.: Evidence for B-cell origin of reticulum cell sarcoma. Virchows Arch. A. Path. Anat. 364, 51 (1974).Google Scholar
  153. Stein, H., Kaiserling, E., Lennert, K.: “Lympho-plasmocytoid immunocytoma — a new entity of human non-Hodgkin’s lymphoma”. 10th International Congress of the International Academy of Pathology, September 16, Hamburg 1974.Google Scholar
  154. Stein, H., Kaiserling, E., Stein, G.: Surface markers on hairy cells. Boll. Ist. sieroter. milan. Special Issue 53, 295(1974).Google Scholar
  155. Stein, H., Bartels, H., Wiemer, H., Kaiserling, E.: Das Vorkommen von Immunglobulinen der Klassen D und E in malignen Lymphomen. Verh. dtsch. Ges. inn. Med. 81, 1586 (1975).PubMedGoogle Scholar
  156. Stein, H., Petersen, N., Gaedicke, G., Lennert, K., Landbeck, G.: Lymphoblastic lymphoma of convoluted or acid phosphatase type — a tumor of T-precursor cells. Int. J. Cancer 17, 292 (1976).PubMedCrossRefGoogle Scholar
  157. Stein, H., Bouman, H., Lennert, K., Fuchs, J., Havsteen, B.: Isoelectric focusing pattern of IgM and surface markers in non-Hodgkin’s lymphoma. In: Immunological diagnosis of leukemias and lymphomas. Haematology and blood transfusion (Thierfelder, S., Rodt, H., Thiel, E., Eds.), Vol. 20, pp. 315–326. Berlin-Heidelberg-New York: Springer 1977.CrossRefGoogle Scholar
  158. Stein, H., Papadimitriou, C.S., Bouman, H., Lennert, K., Fuchs, J.: Demonstration of immunoglobulin production by tumor cells in non-Hodgkin’s and Hodgkin’s malignant lymphomas and its significance for their classification. In: Lymphoid neoplasias I, Recent Resuults in Cancer Research (Mathé, G., Seligmann, M., Tubiana, M., Eds.), Vol. 64, pp. 158–175. Berlin-Heidelberg-New York: Springer 1978.Google Scholar
  159. Stein, H., Bonk, A., Tolksdorf, G., Lennert, K., Rodt, H., Gerdes, J.: Immunohistologic analysis of the organization of normal lymphoid tissue and non-Hodgkin’s lymphomas. J. Histochem. Cytochem. 28, 746 (1980).PubMedCrossRefGoogle Scholar
  160. Stein, H., Mason, D.Y., Gerdes, J., Ziegler, A., Naiem, M., Wernet, P., Lennert, K.: Immunohistology of B cell lymphomas. In: Leukemia markers (Knapp, W., Ed.), pp. 99–108. London: Academic Press 1981.Google Scholar
  161. Stein, H., Staudinger, M., Tolksdorf, G., Lennert, K.: Immunologic markers in the differential diagnosis of non-Hodgkin’s lymphomas. J. Cancer Res. Clin. Oncol. 101, 29 (1981).PubMedCrossRefGoogle Scholar
  162. Stein, H., Thoenes, J., Klatt, U., Gerdes, J., Müller, V., Havsteen, B.: Molecular weight analysis of Fc γ-binding proteins of lymphoid leukemia, and hairy-cell leukemia. J. Cancer Res. Clin. Oncol. 101, 75 (1981).PubMedCrossRefGoogle Scholar
  163. Sternbberg, C.: Über eine eigenartige unter dem Bilde der Pseudoleukämie verlaufende Tuberculose des lymphatischen Apparates. Zeitschr. Heilk. 19, 21 (1898).Google Scholar
  164. Sternberg, C.: Leukosarkomatose und Myeloblastenleukämie. Beitr. path. Anat. 61, 75–100 (1916).Google Scholar
  165. Sutherland, R., Smart, J., Niaudet, P., Graeves, M.: Acute lymphoblastic leukemia associated antigen. II. Isolation and partial characterization. Leuk. Res. 2, 115 (1978).CrossRefGoogle Scholar
  166. Symmers, D.: Follicular lymphadenopathy with splenomegaly. A. newly recognized disease of the lymphatic system. Arch. Path. 3, 816 (1927).Google Scholar
  167. Taylor, C.R., Burns, J.: The demonstration of plasma cells and other immunoglobulin-containing cells in formalin-fixed, paraffin-embedded tissues using peroxidase-labelled antibody. J. clin. Path. 27, 14 (1974).PubMedCrossRefGoogle Scholar
  168. Thiel, E., Rodt, H., Netzel, B., Huhn, D., Wündisch, G.F., Haas, R.J., Bender-Götze, C., Thierfelder, S.: T-Zell-Antigen positive, E-Rosetten negative akute Lymphoblastenleukämie. Blut 36, 363 (1978).PubMedCrossRefGoogle Scholar
  169. Thoenes, J., Stein, H.: Properties of an Fc γ-binding protein isolated from human leukemic B cells. J. exp. Med. 150, 1049 (1979).PubMedCrossRefGoogle Scholar
  170. Tolksdorf, G., Stein, H.: Acid alpha-naphthyl acetate esterase in hairy cell leukemia cells and other cells of the hematopoietic system. Blut 39, 165–176 (1979).PubMedCrossRefGoogle Scholar
  171. Tolksdorf, G., Stein, H., Lennert, K.: Morphological and immunological definition of a malignant lymphoma derived from germinal-centre cells with cleaved nuclei (centrocytes). Brit. J. Cancer 41, 168 (1980).PubMedCrossRefGoogle Scholar
  172. Trubowitz, S., Masek, B., Frasca, J.M.: Leukemic reticuloendotheliosis. Blood 38, 288 (1971).PubMedGoogle Scholar
  173. Veldman, J.E.: Histophysiology and electron microscopy of the immune response. Thesis, Univ. of Groningen 1970.Google Scholar
  174. Virchow, R.: Weißes Blut. Neue Notizen aus dem Gebiet der Natur- und Heilkunde. Froriep’s neue Notizen 36, 151 (1845).Google Scholar
  175. Virchow, R.: Zur pathologischen Physiologie des Blutes. II. Weißes Blut (Leukämie). Virchows Arch. path. Anat. 1, 563 (1847).Google Scholar
  176. Virchow, R.: Die krankhaften Geschwülste, Vol. 2. Berlin: Hirschwald 1864/65.Google Scholar
  177. Vogler, L.B., Crist, W.M., Bockmann, D.E., Pearl, E.R., Lawton, A.R., Cooper, M.D.: Pre-B-cell leukemia. A new phenotype of childhood lymphoblastic leukemia. New Engl. J. Med. 298, 872 (1978).PubMedCrossRefGoogle Scholar
  178. Waldenström, J.: Incipient myelomatosis or “essential” hyperglobulinemia with fibrinogenopenia-A new syndrom? Acta med. Scand. 117, 216 (1944).CrossRefGoogle Scholar
  179. Waldenström, J.: Clinical diagnosis and biochemical findings in material of 296 sera with M-type, narrow gamma globulins. Acta med. scand. 367, 110 (1961).Google Scholar
  180. Wernet, P., Siegal, F.P., Dickler, H., Bentwich, Z., Fu, S., Kunkel, H.G.: B and T cells in various disease states: Immature B cells in the blood of certain patients with immune deficiency. Adv. Biosciences 12, 169 (1974).Google Scholar
  181. Westerhausen, M., Oehlert, W.: Chronisches pluripotentielles immunoproliferatives Syndrom. Dtsch. med. Wschr. 97, 1407 (1972).PubMedCrossRefGoogle Scholar
  182. White, R.G.: The relation of the cellular responses in germinal or lymphocytopoietic centers of lymph nodes to the production of antibody. In: Holub, M., Jaroŝková, L. (eds.): Mechanism of antibody formation, p. 25. Prague: Publishing House of Czechoslovak Academy of Sciences; 1960Google Scholar
  183. White, R.G.: The relation of the cellular responses in germinal or lymphocytopoietic centers of lymph nodes to the production of antibody. In: Holub, M., Jaroŝková, L. (eds.): Mechanism of antibody formation, p. 25. New York: Academic Press 1960.Google Scholar
  184. Winkelmann, R.K.: Clinical studies of T-cell erythroderma in the Sézary syndrome. Clin. Proc. Mayo 49, 519 (1974).Google Scholar
  185. Yam, L.T., Li, C.Y., Lam, K.W.: Tartrat resistant acid phosphatase isoenzyme in the reticulum cells of leukemic reticulo endotheliosis. New Engl. J. Med. 284, 357 (1971).PubMedCrossRefGoogle Scholar
  186. Zollinger, H.U.: Die pathologische Anatomie der Makroglobulinämie Waldenstrom. Helv. med. Acta 25, 153(1958).PubMedGoogle Scholar
  187. Zucker-Franklin, D.: Properties of the Sézary lymphoid cell. An ultrastructural analysis. Mayo Clin. Proc. 49, 567 (1974).PubMedGoogle Scholar
  188. Zucker-Franklin, D., Franklin, E.C., Cooper, N.S.: Production of macroglobulins in vitro and a study of their cellular origin. Blood 20, 56 (1962).Google Scholar
  189. Zucker-Franklin, D., Melton, J.W., III, Quagliata, F.: Ultrastructural, immunologic, and functional studies on Sézary cells: A neoplastic variant of thymus-derived (T) lymphocytes. Proc. nat. Acad. Sci. (Wash.) 71, 1877 (1974).PubMedCrossRefGoogle Scholar
  190. Zur Hausen, H., Schulte-Holthausen, H., Klein, G., Heule, G., Heule, W., Clifford, P., Santessan, L.: EBV-DNA in biopsies of Burkitt tumors and anaplastic carcinomas of the carcinomas. Nature (Lond.) 228, 1056 (1970).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • H. Stein

There are no affiliations available

Personalised recommendations