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Drug-Induced Damage to the Embryo or Fetus

(Molecular and Multilateral Approach to Prenatal Toxicology)
  • D. Neubert
  • H. J. Barrach
  • H.-J. Merker
Part of the Current Topics in Pathology book series (CT PATHOLOGY, volume 69)

Abstract

The exclusion of possible toxicologic hazards is still encumbered with the evaluation of three problems involving major difficulties: carcinogenicity, “teratogenicity,” and mutagenicity. In this paper we will survey some aspects of a modern approach to studying problems of prenatal toxicology, suggesting multilateral ways of handling these problems and, possibly, overcoming the difficulties involved. So far, research in prenatal toxicology has suffered from the inability to incorporate basic pharmacologic and toxicologic, as well as biochemical and altrastructural, aspects. Until recently, routine screening of possible teratogenic effects and “basic research” into abnormal mammalian development were mostly confined to applying simple macroscopic, morphological techniques.

Keywords

Cleft Palate Teratogenic Effect Uterine Horn Prenatal Development NMRI Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • D. Neubert
  • H. J. Barrach
  • H.-J. Merker

There are no affiliations available

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