Zusammenfassung
Dextran ist ein Plasmaersatzstoff, der antithrombotische Eigenschaften besitzt. Dextranprä- parate, welche von klinischem Interesse sind, haben entweder ein mittleres Molekulargewicht (\(\left( {{{{\bar{M}}}_{w}} = Gewichtsmittel} \right)\) = Gewichtsmittel) von 60 000–75 000, sog. klinisches Dextran, oder das \({{\bar{M}}_{w}}\) beträgt ca. 40 000, man spricht dann von sog. niedermolekularem Dextran. Dextran 40 steht für ein Präparat, in welchem das Dextran ein \({{\bar{M}}_{w}}\) von ca. 40 000 aufweist.
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Literatur
Aarburg R von, Gruber UF (1978) Prophylaxe postoperativer thromboembolischer Komplikationen bei hüftgelenksnahen Frakturen. Unfallheilkunde 81: 475
Åberg M, Bergentz SE, Hedner U (1975) The effect of dextran on the lysability of ex vivo thrombi. Ann Surg 181: 342
Åberg M, Hedner U, Bergentz SE (1979) Effect of dextran on factor VIII (antihemophilic factor) and platelet function. Ann Surg 189: 243
Ahlberg A (1969) Trombosprofylax med Macrodex i ett collumfrakturmaterial. In: Haeger K, Robertson B (Hrsg) Trombus och Status posttromboticus. Studentlitteratur, Lund, S 89
Ahlberg A, Nylander G, Robertson B, Cronberg S, Nilsson IM (1968) Dextran in prophylaxis of thrombosis in fractures of the hip. Acta Chir Scand 387: 83
Atik M, Harkess JW, Wichman H (1970) Prevention of fatal pulmonary embolism. Surg Gynecol Obstet 130: 403
Barber HM, Feil EJ, Galasko CSB, Edwards DH, Sutton RA, Haynes DW, Bentley G (1977) A comparative study of dextran 70, warfarin and low-dose heparin for the prophylaxis of thrombo-embo-lism following total hip replacement. Postgrad Med J 53: 130
Becker J, Schampi B (1973) The incidence of postoperative venous thrombosis of the legs. A comparative study on the prophylactic effect of dextran 70 and electrical calf muscle stimulation. Acta Chir Scand 139: 357
Bergentz SE (1978) Dextran prophylaxis of venous thromboembolism. In: Bergan J, Yao J (eds) Venous problems in surgery. Year Book Publishers, Chicago
Bergqvist D, Dahlgren S (1973) Leg vein thrombosis diagnosed by 125I-fibrinogen test in patients with fracture of the hip: a study of the effect of early prophylaxis with dicoumarol or dextran 70. Vasa 2: 121
Bergqvist D, Efsing HO, Hallböök T, Hedlund T (1977) Prophylaxis of thromboembolic complications in hip surgery - a controlled trial with low dose heparin and dextran 70. Thromb Haemostas 38: 238
Bergqvist E, Bergqvist D, Bronge A, Dahlgren S, Lindquist B (1972) An evaluation of early thrombosis prophylaxis following fracture of the femoral neck. Acta Chir Scand 138: 689
Bonnar J, Walsh J (1972) Prevention of thrombosis after pelvic surgery by Britisch dextran 70. Lancet I: 614
Brisman R, Parks LC, Haller JA Jr (1970) Dextran prophylaxis of thromboembolism in high surgical patients. Circulation [Suppl III] 42: 111
Brisman R, Parks LC, Haller JA (1971) Dextran prophylaxis in surgery. Ann Surg 174: 137
Bronge A, Dahlgren S, Lindqvist B (1971) Prophylaxis against thrombosis in femoral neck fractures. A comparison between dextran 70 and dicoumarol. Acta Chir Scand 137: 29
Carter AE, Eban R (1973) The prevention of postoperative deep venous thrombosis with dextran 70. Br J Surg 60: 681
Daniel WJ, Moore AR, Flanc C (1972) Prophylaxis of deep vein thrombosis with dextran 70 in patients with a fractured neck of the femur. Aust NZ J Surg 41: 289
Davidson AI, Brunt MEA, Matheson NA (1972) A further trial comparing dextran 70 with warfarin in the prophylaxis of postoperative venous thrombosis. Br J Surg 59: 314
Evarts CM, Feil EI (1971) Prevention of thromboembolic disease after elective surgery of the hip. J Bone Joint Surg 53: 1271
Geloven F van, Wittebol P, Sixma JJ (177) Comparison of postoperative eoumarin, dextran 40 and subcutaneous heparin in the prevention of postoperative deep vein thrombosis. Acta Med Scand 202: 367
Gruber UF (1968) Blutersatz. Springer, Berlin Heidelberg New York
Gruber UF (1977) Editorial: Clinical research in thromboembolism. What is important for the urologist? Urol Res 5: 49
Gruber UF (1977) Prevention of thromboembolic complications. The problem and alternatives. Acta Univ Ups 3: 55
Gruber UF, Bergentz SE (1966) The antithrombotic effect of dextran. J Surg Res 6: 379
Gruber UF, Schnyder M, Aarburg R von (1977) Thromboembolische Komplikationen in der Chirurgie des Bewegungsapparates. Orthopäde 6: 186
Gruber UF, Duckert F, Fridrich R, Torhorst J, Rem J (1977) Prevention of postoperative thromboembolism by dextran 40, low doses of heparin or xantinol-nicotinate. Lancet I: 207
Gruber UF, Buser P, Frick J, Loosli J, Matt E, Segesser D (1977) Sulfinpyrazone and postoperative deep vein thrombosis. Eur Surg Res 9: 303
Gruber UF, Brun M, Brunner R, Gaugier U, Müller J, Schumacher S, Tichy J, Hohl M (1978) Heparin or dextran for prevention of fatal pulmonary emboli? Abstracts, P 63, p. 78. 13th Congress of the European Society for Surgical Research, Helsinki, May 21–24, 1978. (Heisingin yliopiston monistus- palvelu)
Gruber UF, Brokop T, Eklöf B, Eriksson I, Goldie I, Gran L, Hohl M, Jonsson T, Kristersson S, Ljungström KG, Lund T, Maartman Moe H, Saldeen T, Thomson D, Torhorst J, Trippestad A, Ulstein M (1980) Incidences of fatal postoperative pulmonary embolism after prophylaxis with dextran 70 and low dose heparin: an international multicentre study. Br Med J 280:69
Harper DR, Dhall DP, Woodruff PWH (1973) Prophylaxis in iliofemoral venous thrombosis. The major amputee as a clinical research model. Br J Surg 60: 831
Harris WH, Salzman EW, Athanasoulis C, Waltman AC, Baum S, Danctis RW (1974) Comparison of warfarin, low-molecular-weight dextran, aspirin and subcutaneous heparin in prevention of venous thromboembolism following total hip replacement. J Bone Joint Surg [Am] 56: 1552
Hartshorn JWS, Teale SN, Faiz M (1969) Dextran 75 and postoperative phlebitis. Evaluation of dextran 75 in the prophylaxis of postoperative thrombophlebitis, pulmonary embolism and myocardial infarction. Arch Surg 98: 694
Hedin H (1977) Dextran-induced anaphylactoid reactions in man. Immunological in vitro and in vivo studies. Acta Univ Ups 432 Thesis
Hedlund PO (1975) Postoperative venous thrombosis in benign prostatic disease. A study of 316 patients using the I-125-fibrinogen uptake test. Scand I Urol Nephrol [Suppl] 27: 100
Hohl M, Lüscher KP, Annaheim M, Gruber UF (1978) Heparin oder DHE-Heparin als Thromboseprophylaxe in der Gynäkologie? Abstrakt 456. 42. Tagung der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe, München
Hospenthal J von, Frey Ch, Rutishauser G, Gruber UF (1977) Thromboseprophylaxe bei transurethraler Prostataresektion. Urologe [A] 16: 88
Hubens A, Peeters R, Dewilde T, Klaes R (1976) A clinical trial of low molecular weight dextran and low doses of heparin in the prophylaxis of deep vein thrombosis after abdominal surgery. In: Greep JM, de Boer HHM, den Olter G (eds) General surgery, orthopaedics, plastic surgery, controversial opinions. Excerpta Medica, Amsterdam Oxford, p 188
Huttunen HJ, Mattila MAK, Hakalehto J, Kettunen K, Rehnberg V, Babinsky M (1971) Single infusion of dextran 70 in the prophylaxis of postoperative deep vein thrombosis. Ann Chir Gynaecol 60: 119
Huttunen H, Mattila MAK, Alhava EM, Kettunen K, Kaijalainen P, Poikolainen P, Huttunen K (1977) Peroperative infusion of dextran 70 and dextran 40 in the prevention of postoperative deep venous thrombosis as confirmed by the I-125-labelled fibrinogen uptake method. Ann Chir Gynaecol 66: 79
Jansen H (1972) Postoperative thromboembolism and its prevention with 500 ml dextran given during operation. Acta Chir Scand [Suppl] 427: Thesis
Johnsson SR, Bygdeman S, Eliasson R (1968) Effect of dextran on postoperative thrombosis. Acta Chir Scand [Suppl] 387: 80
Kline A, Hughes LE, Campbell H, Williams A, Zlosnick J, Leach KG (1975) Dextran 70 in prophylaxis of thromboembolic disease after surgery: a clinically oriented randomized double-blind trial. Br Med J II: 109
Koekenberg LJL (1962) Experimental use of Maerodex as prophylaxis against post-operative thromboembolism. Bull Soc Int Chir 21: 501
Korvald E, Staren EJ, Ongre A (1973) Simultaneous use of warfarin-sodium and dextran 70 to prevent postoperative venous thrombosis in patients with hip fractures. J Oslo City Hosp 23: 25
Lambie JM, Barber DC, Dhall DP, Matheson NA (1970) Dextran 70 in prophylaxis of postoperative venous thrombosis. A controlled trial. Br Med J 1: 144
McCarthy TG, Mueen J, Johnstone FD, Weston J, Campbell S (1974) A comparison of low-dose subcutaneous heparin and intravenous dextran 70 in the prophylaxis of deep venous thrombosis after gynaecological surgery. J Obstet Gynaecol Br Cwlth 81: 486
Manus F (1976) The incidence of deep venous thrombosis after total hip replacement using dextran 70 prophylaxis - a venographic study. Ir J Med Sci 145: 201
Messmer K, Schmid-Schoenbein H (1975) Intentional hemodilution (eds). Bibl Haematol 41
Myhre HO, Holen A (1969) Thromboseprofylakse. Dextran eller warfarin-natrium? Nord Med 82: 1534
Myrvold HE, Persson JE, Svensson B, Wallensten S, Vikterloef KJ (1973) Prevention of thrombo-em-bolism with dextran 70 and heparin in patients with femoral neck fractures. Acta Chir Scand 139: 609
Nillius SA (1978) On thromboembolism after total hip replacement. Thesis, University of Lund, Malmö
Renney JTG, Kakkar W, Nicolaides AN (1970) The prevention of postoperative deep-vein thrombosis, comparing dextran 70 and intensive physiotherapy. Br J Surg 57: 388
Ring J, Messmer K (1977) Incidence and severity of anaphylactoid reactions to colloid volume substitutes. Lancet I: 466
Ruckley CV (1974) Heparin versus dextran in the prevention of deep-vein thrombosis. A multi-unit controlled trial. Lancet II: 118
Salzman EW (1974) Drugs affecting platelet function in venous thromboembolism. Thromb Diath Haemorrh [Suppl] 60: 497
Sawyer RB (1968) Clincial experiences with dextran treatment. Acta Chir Scand [Suppl] 387: 58
Schaub N, Duckert F, Fridrich R, Gruber UF (1975) Häufigkeit postoperativer tiefer Venenthrombosen bei Patienten der Allgemeinen Chirurgie und Urologie. Eine Untersuchung mit dem 12 5 J-Fi- brinogentest bei 95 Patienten ohne medikamentöse Prophylaxe. Arch Klin Chir 340: 23
Schnyder M, Gruber UF (1977) Prophylaxe postoperativer tiefer Venenthrombosen in der elekti- ven Hüftchirurgie. Aktuel Traumatol 7: 275
Smith RC, Elton RA, Orr JD, Hart AJL, Graham DF, Fuller GAG, Rundle JS, Maherson AIS, Ruekley CV (1978) Dextran and intermittent pneumatic compression in prevention of postoperative deep vein thrombosis: multiunit trial. Br Med J I: 952
Sobotka MR (1976) Prevention of postoperative deep venous thrombosis by low-molecular weight dextran. In: Greep JM, Boer HHM de, Otter G den (eds) General surgery, orthopaedics, plastic surgery, controversial opinions. Excerpta Medica, Amsterdam Oxford, p 184
Stadil F (1970) Prevention of venous thrombosis. Lancet II: 50
Steinmann E, Duckert F, Gruber UF (1975) Wert von Dextran 70 zur Thromboseprophylaxe in der allgemeinen Chirurgie, Orthopädie, Urologie und Gynäkologie. Schweiz Med Wochenschr 105: 1637
Stephenson CBS, Wallace JC, Vaughan JV (1973) Dextran 70 in the prevention of post-operative deep- vein thrombosis with observations on pulmonary embolism: Report on a pilot study. NZ Med J 77: 302
Literaturnachtrag
Bergentz SE (1978) Dextran in the prophylaxis of pulmonary embolism. World J Surg 2: 19
Bergqvist D, Efsing HO, Hallböök T, Hedlund T (1979) Thromboembolism after elective and posttraumatic hip surgery - a controlled prophylactic trial with dextran 70 and low-dose heparin. Acta chir scand 145: 213
Gruber UF (1980) Chairman: What should I do for prevention of thromboembolic complications? In All-göwer M and Harder’s F (eds) State of the Art of Surgery. Springer, Berlin Heidelberg New York, p 115
Gruber UF (1980) Invited commentary to the article “Prevention of postoperative deep vein thrombosis in Sweden. Results of a survey”. World J Surg 4: 493
Gruber UF (1981) Prevention of deep venous thrombosis: review of prospective, randomized studies. Vascular Diagnosis & Therapy 2:17
Gruber UF (1981) Dextran. Biochemische Wirkung, ärztliche Überwachung und Laboratoriumskontrolle. In: Marx R, Thies HA (eds) Kontrolle von Antithrombotika. XXIII. Hamburger Symposion über Blutgerinnung. Editiones “Roche”, Basel-Grenzach, p 255
Gruber UF, Gorgerat JF, Kraan P, Bucher H, Buhler JC, Giezendanner J, Hänni K, Kägi F, Kläy K, Meyer E, Müller H, Naumann K, Neuenschwander S, Parpan D, Pfyl T, Saxer U, Scholler JM, Schwarz H, Torhorst J (in press) Prevention of fatal postoperative pulmonary embolism by heparin-dihydro- ergotamine or dextran 70
Hohl M, Lüscher KP, Gruber UF (1978) Nebenwirkungen bei perioperativer Thromboembolieprophylaxe. Gynäkologe 11: 45
Messmer K, Ljungström KG, Gruber UF, Richter W, Hedin H (1980) Prevention of dextran-induced anaphylactoid reactions by hapten inhibition. Lancet I: 975
Messmer K, Seemann C, Hedin H, Richter W, Peter K (1980) Anaphylaktoide Reaktionen nach Dextran: II Tierexperimentelle und klinische Ergebnisse der Prophylaxe durch Hapten-Hemmung. Allergologie 3: 17
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Gruber, U.F. (1981). Thromboembolieprophylaxe mit Dextran. In: Vinazzer, H. (eds) Thrombose und Embolie. Anaesthesiologie und Intensivmedizin/Anaesthesiology and Intensive Care Medicine, vol 134. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67843-1_17
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DOI: https://doi.org/10.1007/978-3-642-67843-1_17
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