Drug Influences upon Skin Test Reactivity

  • E. Schöpf


This topic does not reflect a new trend in allergy research. In the contrary, it is a very old question, of relevance because of the common use of skin tests in the investigation of allergic diseases. Therefore it is surprising to note on surveying the literature that exact results regarding this topic gained in investigations in man are rare.


Allergy Clin Immunol Disodium Cromoglycate Skin Test Reaction Passive Cutaneous Anaphylaxis Patch Test Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Ash ASF, Schild HO (1966) Receptors mediating some actions of histamine. Br J Pharmacol Chemother 27:427–439PubMedGoogle Scholar
  2. 2.
    Black JW, Duncan WAD, Durant CJ, Ganellin CR, Parsons EM (1972) Definition and antagonism of H2 receptors. Nature 236:358CrossRefGoogle Scholar
  3. 3.
    Braun W, Lauppe U (1969) Die Beeinflussung allergologischer Tests durch Antihistaminika und Kortikosteroide. Schattauer, StuttgartGoogle Scholar
  4. 4.
    Cook TJ, MacQueen DM, Wittig HJ, Thonby JI, Lantos RL, Virtue CM (1973) Degree and duration of supression and side effects with antihistamines. J Allergy Clin Immunol 51:71PubMedCrossRefGoogle Scholar
  5. 5.
    Ebner H (1977) Zur Beeinflussung allergischer Testreaktionen vom Soforttyp durch eine topische Vorbehandlung mit einer betaadrenergen Substanz. Wien Med Wochschr 127:292–294Google Scholar
  6. 6.
    Galant SP, Bullock J, Wong D, Maibach HI (1973) The inhibitory effect of antiallergy drugs on allergen and histamine induced wheal and flare response. J Allergy Clin Immunol 51:11–21PubMedCrossRefGoogle Scholar
  7. 7.
    Goodman LS, Gilman A (1975) The pharmacological basis of therapeutics, 5th edn. Macmillan, New York, p 604Google Scholar
  8. 8.
    Hamburger RN (1975) Peptide inhibition of the Prausnitz-Küstner reaction. Science 189:389–390PubMedCrossRefGoogle Scholar
  9. 9.
    Hauge HE, Vale IR (1965) The influence of triamcinolone on the allergy skin wheal reaction. Acta allergol (Copenh) 20:496Google Scholar
  10. 10.
    Hutchcroft BJ, Moore EG, Orange RP (1979) The effects of H1 and H2 receptor antagonism on the response of monkey skin to intradermal histamine, reverse-type anaphylaxis, and passive cutaneous anaphylaxis. J Allergy Clin Immunol 63:376–382PubMedCrossRefGoogle Scholar
  11. 11.
    Johnson HG, VanHout CA, Wright JB (1978) Inhibition of allergic reactions by cromoglycate and by a new anti-allergy drug U-42, 585 E. Int Arch Allergy Appl Immunol 56:416–423CrossRefGoogle Scholar
  12. 12.
    Jorde W, Schata M (1976) Inhibitory effect of β-adrenergic stimulants on the histamine reaction in human skin. Arznei Forsch 26:2103–2105Google Scholar
  13. 13.
    Lichtenstein LM, Margolis S (1968) Histamine release in vitro. Inhibition by catecholamines and methyl xanthines. Science 161:902PubMedCrossRefGoogle Scholar
  14. 14.
    Lichtenstein LM, Plaut M, Henney C, Gillespie E (1973) The role of H2 receptors on the cells involved in hypersensitivity reactions. In: International symposium on histamine H2 receptor antagonists. Smith, Kline & French, London, p 187Google Scholar
  15. 15.
    Lopez M, Bloch K (1969) Effect of disodium cromoglycate on certain passive cutaneous anaphylactic reactions. J Immunol 103:1428–1430PubMedGoogle Scholar
  16. 16.
    Lovell RR, Goodman HC, Hudson B, Armitage P, Pickering GW (1953) The effects of cortisone and adrenocorticotrophic hormone on experimental inflammations in the human skin. Clin Sci 12:41–55PubMedGoogle Scholar
  17. 17.
    Marks R, Greaves MW (1977) Vascular responses to histamine and compound 48/80 in human skin: Supression by histamine H2 receptor blocking agent. Br J Clin Pharmocol 4:367Google Scholar
  18. 18.
    Nilzen A (1950) The action of histamine antagonists on the histamine wheal and the eczema test (patch test). Acta Derm Venereol (Stockh) 30:1–8Google Scholar
  19. 19.
    Parker D, Turk JL (1978) The effect of cyclophosphamide pretreatment on B-cell stimulation: dissociation of action on homocytotropic antibody and other B-cell functions. Immunology 34:115–122PubMedGoogle Scholar
  20. 20.
    Parrot JL, Wyxzolkowska Y, Santais, MC, Ruff F, Mordelet-Dambrine M, Maslinski C (1974) The action of nicotinamide on the release of histamine. Agents Actions 4:202–203PubMedCrossRefGoogle Scholar
  21. 21.
    Paul W, Beets JL, Bray MA, Morley J (1978) Anti-inflammatory drug actions on allergic responses in guineapig skin. Agents Actions 8:509–514PubMedCrossRefGoogle Scholar
  22. 22.
    Polak L (1980) Immunological aspects of contact sensitivity, an experimental study. Karger, Basel Munich Paris London New York SydneyGoogle Scholar
  23. 23.
    Taylor WA, Daphne HF, Sheldon D, Rom IM (1974) The antianaphylactic actions of disodium cromoglycate, theophylline, isoprenaline and Prostaglandins. Int Arch Allergy Appl Immunol 46:104–120PubMedCrossRefGoogle Scholar
  24. 24.
    Townley RG, Mano K (1978) Comparison of the effects of fenoterol on PCA and histamine skin test in rats. Chest 73:974–976PubMedGoogle Scholar
  25. 25.
    Turk JL, Parker D, Poulter LW (1972) Functional aspects of the selective depletion of lymphoid tissue by cyclophosphamide. Immunology 23:493–501PubMedGoogle Scholar
  26. 26.
    Wurm G, Geres U (1979) Struktur-Wirkungs-Untersuchung an antianaphylaktisch aktiven Flavoncarbonsäure-Derivaten. Arzneim Forsch 219Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • E. Schöpf
    • 1
  1. 1.Universitäts-HautklinikGermany

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