Abstract
This review deals with a singular form of pathology induced by certain drugs, including some of the group that are currently classified as psychomotor stimulants. For historical reasons, this form of pathology is now generically called drug dependence, with subclasses defined in terms of the type of pharmacologic agent that generates or maintains the disorder. Other terms such as toxicomania, habituation, or addiction have been employed for the disease. It is possible that its name will change again in the future as the new, growing knowledge about its nature develops more fully. The main objective of this chapter is to review the disease of dependence to psychomotor stimulants as well as the results of experimental work aimed at understanding and measuring the dependence-producing properties that these drugs possess. Simultaneous attention to these two levels of study — analysis of dependence as a disease and experimental analysis of drug actions related to dependence production — has been deemed necessary to maintain the complete perspective that the subject requires.
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References
Balster, R.L., Schuster, C.R.: Fixed-interval schedule of cocaine reinforcement: effect of dose and infusion duration. J. Exp. Anal. Behav. 20, 119–129 (1973)
Balster, R.L., Kilbey, M.M., Ellinwood, jr., E.H.: Methamphetamine self-administration in the cat. Psychopharmacologia (Berl.) 46, 229–233 (1976)
Bedford, J.A., Bailey, L.P., Wilson, M.C.: Cocaine reinforced progressive-ratio performance in the rhesus monkey. Pharmacol. Biochem. Behav. 9, 631–638 (1978)
Bedford, J.A., Borne, R.F., Wilson, M.C.: Comparative behavioral profile of cocaine and nor-cocaine in rats and monkeys. Pharmacol. Biochem. Behav. 13, 69–75 (1980)
Bejerot, N.: spivn In: Sjöqvist, F., Tottie, M. (eds.): Abuse of central stimulants, p. 298. Stockholm: Almqvist & Wiksell 1969
Boissier de Sauvages, F.: Nosologie methodique. French translation by Nicolas, M. (1771) of the original Latin version of 1762. Facsimile at the National Library of Medicine, Washington, D.C.
Carey, J.T., Mandel, J.: A San Francisco bay area “speed” scene. J. Hlth. Soc. Behav. 9, 164–174 (1968)
Catania, A.C.: Drug effects and concurrent performances. Pharmacol. Rev. 27, 385–394 (1976)
Clineschmidt, B.V., Hanson, H.M., Pflueger, A.B., McGuffin, J.C.: Anorexigenic and ancillary actions of MK-212 (6-chloro-2-[1-piperazinyl]-pyrazine; CPP). Psychopharmacology 55, 27–33 (1977)
Cytawa, J., Jurkowlaniec, E., Biatowas, J.: Positive reinforcement produced by noradrenergic stimulation of the hypothalamus in rats. Physiol. Behav. 25, 615–619 (1980)
Deneau, G.A., Yanagita, T., Seevers, M.H.: Self-administration of psychoactive substances by the monkey: a measure of psychological dependence. Psychopharmacologia (Berl.) 16, 30–48 (1969)
De V. Cotten, M. (ed): Symposium on control of drug taking behavior by schedules of reinforcement. Pharmacol. Rev. 27, 291–548 (1976)
Dougherty, J., Pickens, R.: Fixed-interval schedules of intravenous cocaine presentation in rats. J. Exp. Anal. Behav. 20, 111–118 (1973)
Dougherty, J., Pickens, R.: Pharmacokinetics of intravenous cocaine selfinjection. In: Mulé, S.J. (ed.) Cocaine: chemical, biological, clinical, social, and treatment aspects. Cleveland, Ohio: CRC Press 1976
Down, D.A., Woods, J.H.: Food- and drug-reinforced responding: effects of DITA and d-am-phetamine. Psychopharmacologia (Berl) 43, 13–17 (1975)
Elsmore, T.F., Fletcher, G.V., Conrad, D.G., Sodetz, F.J.: Reduction of heroin intake in baboons by an economic constraint. Pharmacol. Biochem. Behav. 13, 729–731 (1980)
Estrada, U., Villarreal, J.E., Schuster, C.R.: Self-administration of stimulant drugs as a function of the dose per injection. Minutes of the twenty-seventh meeting of the CPDD. pp. 5056–5059. National Academy of Sciences, Washington, D.C. 1967
Findley, J.D., Robinson, W.W., Gilliam, W.: A restraint system for chronic study of the baboon. J. Exp. Anal. Behav. 15, 69–71 (1971)
Findley, J.D., Robinson, W.W., Peregrino, L.: Addiction to secobarbital and chlordiazepoxide in the rhesus monkey by means of self-infusion preference procedure. Psychopharmacologia (Berl.) 26, 93–114 (1972)
Goldberg, S.R.: Comparable behavior maintained under fixed-ratio and second-order schedules of food presentation, cocaine injection or d-amphetamine injection in the squirrel monkey. J. Pharmacol. Exp. Ther. 186, 18–30 (1973)
Goldberg, S.R., Morse, W.H., Goldberg, D.M.: Behavior maintained under a second-order schedule by intramuscular injection of morphine or cocaine in rhesus monkeys. J. Pharmacol. Exp. Ther. 199, 278–286 (1976)
Griffith, J.D.: A study of illicit amphetamine drug traffic in Oklahoma City. Amer. J. Psychiat. 123, 560–569 (1966)
Griffith, J.D.: Amphetamine dependence; clinical features. In: Martin, W.R. (ed.): Drug addiction II. pp. 277–304. Handb. exp. pharm. Vol. 45/II. Berlin Heidelberg New York: Springer-Verlag 1977
Griffiths, R.R., Findley, J.D., Brady, J.V., Dolan-Gutcher, K., Robinson, W.: Comparison of progressive-ratio performance maintained by cocaine, methylphenidate, and secobarbital. Psychopharmacologia (Berl.) 43, 81–83 (1975)
Griffiths, R.R., Winger, G., Brady, J.V., Snell, J.D.: Comparison of behavior maintained by infusions of eight phenylethylamines in baboons. Psychopharmacology 50, 251–258 (1976)
Griffiths, R.R., Brady, J.V., Snell, J.D.: Progressive-ratio performance maintained by drug infusions: comparison of cocaine, diethylpropion, chlorphentermine, and fenfluramine. Psychopharmacology (Berl.) 56, 5–13 (1978a)
Griffiths, R.R., Brady, J.V., Snell, J.D.: Relationship between anoretic and reinforcing properties of appetite suppressant drugs: implications for assessment of abuse liability. Biol. Psychiat. 13, 283–290 (1978b)
Griffiths, R.R., Bradford, L. DiAnne, Brady, J.V.: Progressive ratio and fixed ratio schedules of cocaine-maintained responding in baboons. Psychopharmacology 65, 125–136 (1979)
Hawks, D., Mitcheson, M., Ogborne, A., Edwards, G.: Abuse of methylamphetamine. Brit. Med. J. 1969 II, 715–721
Herling, S., Downs, D.A., Woods, J.H.: Cocaine, d-amphetamine, and pentobarbital effects on responding maintained by food or cocaine in rhesus monkey. Psychopharmacology 64, 261–269 (1979)
Hodos, W.: Progressive ratio as a measure of reward strength. Science 134, 943–944 (1961)
Hodos, W., Kaiman, G.: Effects of increment size and reinforcer volume on progressive ratio performance. J. Exp. Anal. Behav. 6, 387–392 (1963)
Hoffmeister, F.: Negative reinforcing properties of some psychotropic drugs in drug-naive rhesus monkeys. J. Pharmacol. Exp. Ther. 192, 468–477 (1975)
Hoffmeister, F.: Progressive ratio performance in the rhesus monkey maintained by opiate infusions. Psychopharmacology 62, 181–186 (1979)
Hoffmeister, F., Goldberg, S.R.: A comparison of chlorpromazine, imipramine, morphine, and d-amphetamine self-administration in cocaine-dependent rhesus monkeys. J. Pharmacol. Exp. Ther. 187, 8–14 (1973)
Hoffmeister, F., Wuttke, W.: Further studies on self-administration of antipyretic analgesics with codeine in rhesus monkeys. J. Pharmacol. Exp. Ther. 193, 870–875 (1975)
Hursh, S.R.: Economic concepts for the analysis of behavior. J. Exp. Anal. Behav. 34, 219–238 (1980)
Iglauer, C., Woods, J.H.: Concurrent performances: reinforcement by different doses of intravenous cocaine in rhesus monkeys. J. Exp. Anal. Behav. 22, 179–196 (1974)
Iglauer, C., Llewellyn, M.E., Woods, J.H.: Concurrent schedules of cocaine injection in rhesus monkeys: dose variations under independent and non-independent variable-interval procedures. Pharmacol. Rev. 27, 367–383 (1976)
Jasinski, D.R., Gilbert, P.E., Vaupel, B., Risner, M.E., Cone, E.J.: Stimulant self-administration studies in dog. Progress Report from the NIDA addiction research center. Proceedings of the fortieth annual scientific meeting of the CPDD, pp. 171–177. National Academy of Sciences, Washington, D.C. 1978
Johanson, C.E., Schuster, C.R.: A choice procedure for drug reinforcers: cocaine and methyl-phenidate in the rhesus monkey. J. Pharmacol. Exp. Ther. 193, 676–688 (1975)
Johanson, C.E., Schuster, C.R.: A comparison of cocaine and diethylpropion under the different schedules of drug presentation. In: Ellinwood, E.H., Kilbey, M.M. (eds.): Cocaine and other stimulants, pp. 545–570. New York: Plenum 1976
Johanson, C.E., Balster, R.L., Bonese, K.: Self-administration of psychomotor stimulant drugs: the effects of unlimited access. Pharmacol. Biochem. Behav. 4, 45–51 (1976a)
Johanson, C.E., Kandel, D.A., Bonese, K.: The effects of perphenazine on self-administration behavior. Pharmacol. Biochem. Behav. 4, 427–433 (1976b)
Jones, B.E., Prada, J.A.: Relapse to morphine use in dog. Psychopharmacologia (Berl.) 30, 1–12 (1973)
Kallant, O.J.: The amphetamines: toxicity and addiction. Toronto: University of Toronto Press, 1966
Kallant, O.J.: The amphetamines: toxicity and addiction, 2nd ed. Springfield, Ill.: Thomas 1973
Kato, M.: Epidemiology of drug dependence in Japan. In: Zarafonetis, C.J.D. (ed.): Drug abuse, pp. 67–70. Philadelphia: Lea & Febiger 1972
Keesey, R.E., Goldstein, M.D.: Use of progressive fixed ratio procedures in the assessment of intracranial reinforcement. J. Exp. Anal. Behav. 11, 293–301 (1968)
Kelleher, R.T.: Conditioned reinforcement in second-order schedules. J. Exp. Anal. Behav. 9, 475–485 (1966)
Kelleher, R.T.: Characteristics of behavior controlled by scheduled injections of drugs. Pharmacol. Rev. 27, 307–323 (1976)
Kelleher, R.T., Goldberg, S.R.: Fixed-interval responding under second order schedules of food presentation or cocaine injection. J. Exp. Anal. Behav. 28, 221–231 (1977)
Kramer, J.C., Fishman, V.S., Littlefield, D.C.: Amphetamine abuse. Pattern and effects of high doses taken intravenously. J. Amer. Med. Ass. 201, 305–309 (1967)
Masaki, T.: The amphetamine problem in Japan. Wld. Hlth. Org. Techn. Rep. Ser. 102, 14–21 (1956)
Pickens, R., Thompson, T.: Self-administration of amphetamine and cocaine by rats. Minutes of the twenty-seventh meeting of the CPDD, pp. 5049–5055. National Academy of Sciences, Washington, D.C. 1967
Pickens, R., Thompson, T.: Cocaine-reinforced behavior in rats: effects of reinforcement magnitude and fixed ratio size. J. Pharmacol. Exp. Ther. 161, 122–129 (1968)
Risner, M.E.: Intravenous self-administration of d- and L-amphetamine by dog. Eur. J. Pharmacol. 32, 344–348 (1975)
Risner, M.E., Jones, B.E.: Self-administration of CNS stimulants by dog. Psychopharma-cologia (Berl.) 43, 207–213 (1975)
Risner, M.E., Jones, B.E.: Intravenous self-administration of cocaine and norcocaine by dogs. Psychopharmacology 71, 83–89 (1980)
Sánchez-Ramos, J.R., Schuster, C.R.: Second-order schedules of intravenous drug self-administration in rhesus monkeys. Pharmacol. Biochem. Behav. 7, 443–450 (1977)
Schuster, C.R., Johanson, C.E.: Behavioral studies of cathinone in monkeys and rats. In: Harris, L.S. (ed.): Problems of drug dependence, 1979. NIDA research monograph 27, pp. 324–325
Schuster, C.R., Thompson, T.: Self-administration of and behavioral dependence on drugs. Ann. Rev. Pharmacol. 9, 483–502 (1969)
Schuster, C.R., Villarreal, J.E.: Experimental analysis of opioid dependence. In: Efron, D.H. (ed.): Psychopharmacology — a review of progress 1957–1967, pp. 811–828. Washington, D.C.: U.S. Government Printing Office 1968
Sjöqvist, F., Tottie, M. (eds.): Abuse of central stimulants. Stockholm: Almqvist & Wiksell 1969
Smith, R.C.: Speed and violence: compulsive methamphetamine abuse and criminality in the Haight-Ashbury District. In: Zarefonetis, C.J.D. (ed.): Drug abuse, pp. 435–448. Philadelphia: Lea & Febiger 1972
Spealman, R.D.: Behavior maintained by termination of a schedule of self-administered cocaine. Science 204, 1231–1233 (1979)
Spealman, R.D., Goldberg, S.R.: Drug self-administration by laboratory animals: control by schedules of reinforcement. Ann. Rev. Pharmacol. Toxicol. 18, 313–339 (1978)
Stretch, R., Gerber, G.J.: A method for chronic intravenous drug administration in squirrel monkeys. Canad. J. Physiol. Pharmacol. 48, 575–581 (1970)
Sydenham, T.: The works, on acute and chronic diseases (1666–1686). Version published in English by Rush, B. in 1815. Facsimile at National Library of Medicine, Washington, D.C.
Takahashi, R.N., Singer, G., Oei, T.P.S.: Schedule induced self-injection of D-amphetamine by naive animals. Pharmacol. Biochem. Behav. 9, 857–861 (1978)
Tessel, R.E., Woods, J.H.: Fenfluramine and N-ethylamphetamine: comparison of the reinforcing and rate-decreasing actions in the rhesus monkey. Psychopharmacologia (Berl.) 43, 239–244 (1975)
Tessel, R.E., Woods, J.H.: Meta substituted N-ethylamphetamine self-injection responding in the rhesus monkey: estructive-activity relationships. J. Pharmacol. Exp. Ther. 205, 274–281 (1978)
Thompson, T., Schuster, C.R.: Morphine self-administration, food-reinforced, and avoidance behaviors in rhesus monkeys. Psychopharmacologia (Berl.) 5, 87–94 (1964)
Villarreal, J.E.: Contributions of laboratory work to the analysis and control of drug dependence. In: Bachly, P.H. (ed.): Drug abuse, data, and debate, pp. 82–103. Springfield, Ill.: Thomas 1970
Weeks, J.R.: Experimental morphine addiction: method for automatic intravenous injections in unrestrained rats. Science 138, 143–144 (1962)
Wikler, A., Martin, W.R., Pescor, F.T., Eades, C.G.: Factors regulating oral consumption of an opioid (Etonitazine) by morphine-addicted rats. Psychopharmacologia (Berl.) 5, 55–76 (1963)
Wilson, M.C., Schuster, C.R.: The effects of chlorpromazine on psychomotor stimulant self-administration in the rhesus monkey. Psychopharmacologia 26, 115–126 (1972)
Wilson, M.C., Schuster, C.R.: Mazindol self-administration in the rhesus monkey. Pharmacol. Biochem. Behav. 4, 207–210 (1976)
Wilson, M.C., Hitomi, M., Schuster, C.R.: Psychomotor stimulant self-administration as a function of dosage per injection in the rhesus monkey. Psychopharmacologia 22, 271–281 (1971)
Wise, R.A., Yokel, R.A., DeWitt, H.: Both positive reinforcement and conditioned aversion from amphetamine and from apomorphine in rats. Science 191, 1273–1275 (1976)
Wise, R.A., Yokel, R.A., Hansson, P.A., Gerber, G.J.: Concurrent intracranial self-stimulation and amphetamine self-administration in rats. Pharmacol. Biochem. Behav. 7, 459–461 (1977)
Woods, J.H.: Behavioral effects of cocaine in animals. In: Petersen, R.C., Stillman, R.C. (eds.): Cocaine. 1977. NIDA Research monograph 13, pp. 63–95.
Woods, J.H., Tessel, R.E.: Fenfluramine: amphetamine congener that fails to maintain drug-taking behavior in the rhesus monkey. Science 185, 1067–1069 (1974)
World Health Organization, Techn. Rep. Ser., No. 577, Evaluation of dependence liability and dependence potential of drugs 1975
Yanagita, T.: An experimental framework for evaluation of dependence liability in various types of drugs in monkeys. Bull. Narc. 1, 25–57 (1973)
Yanagita, T.: Brief review on the use of self-administration techniques for predicting drug abuse potential. In: Thompson, T., Unna, K. (eds.): Predicting dependence liability of stimulant and depressant drugs, pp. 231–242. Baltimore: University Park 1977
Yanagita, T.: Studies on cathinones: cardiovascular and behavioral effects in rats and self-administration experiment in rhesus monkeys. In: Harris, L.S. (ed.): Problems of drug dependence, 1979. NIDA Research monograph 27, pp. 326–327
Yanagita, T., Deneau, G.A., Seevers, M.H.: Evaluation of pharmacological agents in the monkey by long-term intravenous self- or programmed-adminiseration. Excerpta Med. Int. Congr. Ser. 87, 453–457 (1965)
Young, A.M., Woods, J.H.: Behavior maintained by intravenous injection of codeine, cocaine, and etorphine in the rhesus macaque and the pigtail macaque. Psychopharmacology 70, 263–271 (1980)
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Villarreal, J.E., Salazar, L.A. (1981). The Dependence-Producing Properties of Psychomotor Stimulants. In: Hoffmeister, F., Stille, G. (eds) Psychotropic Agents. Handbook of Experimental Pharmacology, vol 55 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67767-0_16
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