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The Dependence-Producing Properties of Psychomotor Stimulants

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Psychotropic Agents

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 55 / 2))

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Abstract

This review deals with a singular form of pathology induced by certain drugs, including some of the group that are currently classified as psychomotor stimulants. For historical reasons, this form of pathology is now generically called drug dependence, with subclasses defined in terms of the type of pharmacologic agent that generates or maintains the disorder. Other terms such as toxicomania, habituation, or addiction have been employed for the disease. It is possible that its name will change again in the future as the new, growing knowledge about its nature develops more fully. The main objective of this chapter is to review the disease of dependence to psychomotor stimulants as well as the results of experimental work aimed at understanding and measuring the dependence-producing properties that these drugs possess. Simultaneous attention to these two levels of study — analysis of dependence as a disease and experimental analysis of drug actions related to dependence production — has been deemed necessary to maintain the complete perspective that the subject requires.

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References

  • Balster, R.L., Schuster, C.R.: Fixed-interval schedule of cocaine reinforcement: effect of dose and infusion duration. J. Exp. Anal. Behav. 20, 119–129 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Balster, R.L., Kilbey, M.M., Ellinwood, jr., E.H.: Methamphetamine self-administration in the cat. Psychopharmacologia (Berl.) 46, 229–233 (1976)

    Article  CAS  Google Scholar 

  • Bedford, J.A., Bailey, L.P., Wilson, M.C.: Cocaine reinforced progressive-ratio performance in the rhesus monkey. Pharmacol. Biochem. Behav. 9, 631–638 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Bedford, J.A., Borne, R.F., Wilson, M.C.: Comparative behavioral profile of cocaine and nor-cocaine in rats and monkeys. Pharmacol. Biochem. Behav. 13, 69–75 (1980)

    Article  PubMed  CAS  Google Scholar 

  • Bejerot, N.: spivn In: Sjöqvist, F., Tottie, M. (eds.): Abuse of central stimulants, p. 298. Stockholm: Almqvist & Wiksell 1969

    Google Scholar 

  • Boissier de Sauvages, F.: Nosologie methodique. French translation by Nicolas, M. (1771) of the original Latin version of 1762. Facsimile at the National Library of Medicine, Washington, D.C.

    Google Scholar 

  • Carey, J.T., Mandel, J.: A San Francisco bay area “speed” scene. J. Hlth. Soc. Behav. 9, 164–174 (1968)

    Article  CAS  Google Scholar 

  • Catania, A.C.: Drug effects and concurrent performances. Pharmacol. Rev. 27, 385–394 (1976)

    Google Scholar 

  • Clineschmidt, B.V., Hanson, H.M., Pflueger, A.B., McGuffin, J.C.: Anorexigenic and ancillary actions of MK-212 (6-chloro-2-[1-piperazinyl]-pyrazine; CPP). Psychopharmacology 55, 27–33 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Cytawa, J., Jurkowlaniec, E., Biatowas, J.: Positive reinforcement produced by noradrenergic stimulation of the hypothalamus in rats. Physiol. Behav. 25, 615–619 (1980)

    Article  PubMed  CAS  Google Scholar 

  • Deneau, G.A., Yanagita, T., Seevers, M.H.: Self-administration of psychoactive substances by the monkey: a measure of psychological dependence. Psychopharmacologia (Berl.) 16, 30–48 (1969)

    Article  CAS  Google Scholar 

  • De V. Cotten, M. (ed): Symposium on control of drug taking behavior by schedules of reinforcement. Pharmacol. Rev. 27, 291–548 (1976)

    Google Scholar 

  • Dougherty, J., Pickens, R.: Fixed-interval schedules of intravenous cocaine presentation in rats. J. Exp. Anal. Behav. 20, 111–118 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Dougherty, J., Pickens, R.: Pharmacokinetics of intravenous cocaine selfinjection. In: Mulé, S.J. (ed.) Cocaine: chemical, biological, clinical, social, and treatment aspects. Cleveland, Ohio: CRC Press 1976

    Google Scholar 

  • Down, D.A., Woods, J.H.: Food- and drug-reinforced responding: effects of DITA and d-am-phetamine. Psychopharmacologia (Berl) 43, 13–17 (1975)

    Article  Google Scholar 

  • Elsmore, T.F., Fletcher, G.V., Conrad, D.G., Sodetz, F.J.: Reduction of heroin intake in baboons by an economic constraint. Pharmacol. Biochem. Behav. 13, 729–731 (1980)

    Article  PubMed  CAS  Google Scholar 

  • Estrada, U., Villarreal, J.E., Schuster, C.R.: Self-administration of stimulant drugs as a function of the dose per injection. Minutes of the twenty-seventh meeting of the CPDD. pp. 5056–5059. National Academy of Sciences, Washington, D.C. 1967

    Google Scholar 

  • Findley, J.D., Robinson, W.W., Gilliam, W.: A restraint system for chronic study of the baboon. J. Exp. Anal. Behav. 15, 69–71 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Findley, J.D., Robinson, W.W., Peregrino, L.: Addiction to secobarbital and chlordiazepoxide in the rhesus monkey by means of self-infusion preference procedure. Psychopharmacologia (Berl.) 26, 93–114 (1972)

    Article  CAS  Google Scholar 

  • Goldberg, S.R.: Comparable behavior maintained under fixed-ratio and second-order schedules of food presentation, cocaine injection or d-amphetamine injection in the squirrel monkey. J. Pharmacol. Exp. Ther. 186, 18–30 (1973)

    PubMed  CAS  Google Scholar 

  • Goldberg, S.R., Morse, W.H., Goldberg, D.M.: Behavior maintained under a second-order schedule by intramuscular injection of morphine or cocaine in rhesus monkeys. J. Pharmacol. Exp. Ther. 199, 278–286 (1976)

    PubMed  CAS  Google Scholar 

  • Griffith, J.D.: A study of illicit amphetamine drug traffic in Oklahoma City. Amer. J. Psychiat. 123, 560–569 (1966)

    PubMed  CAS  Google Scholar 

  • Griffith, J.D.: Amphetamine dependence; clinical features. In: Martin, W.R. (ed.): Drug addiction II. pp. 277–304. Handb. exp. pharm. Vol. 45/II. Berlin Heidelberg New York: Springer-Verlag 1977

    Google Scholar 

  • Griffiths, R.R., Findley, J.D., Brady, J.V., Dolan-Gutcher, K., Robinson, W.: Comparison of progressive-ratio performance maintained by cocaine, methylphenidate, and secobarbital. Psychopharmacologia (Berl.) 43, 81–83 (1975)

    Article  CAS  Google Scholar 

  • Griffiths, R.R., Winger, G., Brady, J.V., Snell, J.D.: Comparison of behavior maintained by infusions of eight phenylethylamines in baboons. Psychopharmacology 50, 251–258 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Griffiths, R.R., Brady, J.V., Snell, J.D.: Progressive-ratio performance maintained by drug infusions: comparison of cocaine, diethylpropion, chlorphentermine, and fenfluramine. Psychopharmacology (Berl.) 56, 5–13 (1978a)

    Article  CAS  Google Scholar 

  • Griffiths, R.R., Brady, J.V., Snell, J.D.: Relationship between anoretic and reinforcing properties of appetite suppressant drugs: implications for assessment of abuse liability. Biol. Psychiat. 13, 283–290 (1978b)

    CAS  Google Scholar 

  • Griffiths, R.R., Bradford, L. DiAnne, Brady, J.V.: Progressive ratio and fixed ratio schedules of cocaine-maintained responding in baboons. Psychopharmacology 65, 125–136 (1979)

    Article  PubMed  CAS  Google Scholar 

  • Hawks, D., Mitcheson, M., Ogborne, A., Edwards, G.: Abuse of methylamphetamine. Brit. Med. J. 1969 II, 715–721

    Article  Google Scholar 

  • Herling, S., Downs, D.A., Woods, J.H.: Cocaine, d-amphetamine, and pentobarbital effects on responding maintained by food or cocaine in rhesus monkey. Psychopharmacology 64, 261–269 (1979)

    Article  PubMed  CAS  Google Scholar 

  • Hodos, W.: Progressive ratio as a measure of reward strength. Science 134, 943–944 (1961)

    Article  PubMed  CAS  Google Scholar 

  • Hodos, W., Kaiman, G.: Effects of increment size and reinforcer volume on progressive ratio performance. J. Exp. Anal. Behav. 6, 387–392 (1963)

    Article  PubMed  CAS  Google Scholar 

  • Hoffmeister, F.: Negative reinforcing properties of some psychotropic drugs in drug-naive rhesus monkeys. J. Pharmacol. Exp. Ther. 192, 468–477 (1975)

    PubMed  CAS  Google Scholar 

  • Hoffmeister, F.: Progressive ratio performance in the rhesus monkey maintained by opiate infusions. Psychopharmacology 62, 181–186 (1979)

    Article  PubMed  CAS  Google Scholar 

  • Hoffmeister, F., Goldberg, S.R.: A comparison of chlorpromazine, imipramine, morphine, and d-amphetamine self-administration in cocaine-dependent rhesus monkeys. J. Pharmacol. Exp. Ther. 187, 8–14 (1973)

    PubMed  CAS  Google Scholar 

  • Hoffmeister, F., Wuttke, W.: Further studies on self-administration of antipyretic analgesics with codeine in rhesus monkeys. J. Pharmacol. Exp. Ther. 193, 870–875 (1975)

    PubMed  CAS  Google Scholar 

  • Hursh, S.R.: Economic concepts for the analysis of behavior. J. Exp. Anal. Behav. 34, 219–238 (1980)

    Article  PubMed  CAS  Google Scholar 

  • Iglauer, C., Woods, J.H.: Concurrent performances: reinforcement by different doses of intravenous cocaine in rhesus monkeys. J. Exp. Anal. Behav. 22, 179–196 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Iglauer, C., Llewellyn, M.E., Woods, J.H.: Concurrent schedules of cocaine injection in rhesus monkeys: dose variations under independent and non-independent variable-interval procedures. Pharmacol. Rev. 27, 367–383 (1976)

    Google Scholar 

  • Jasinski, D.R., Gilbert, P.E., Vaupel, B., Risner, M.E., Cone, E.J.: Stimulant self-administration studies in dog. Progress Report from the NIDA addiction research center. Proceedings of the fortieth annual scientific meeting of the CPDD, pp. 171–177. National Academy of Sciences, Washington, D.C. 1978

    Google Scholar 

  • Johanson, C.E., Schuster, C.R.: A choice procedure for drug reinforcers: cocaine and methyl-phenidate in the rhesus monkey. J. Pharmacol. Exp. Ther. 193, 676–688 (1975)

    PubMed  CAS  Google Scholar 

  • Johanson, C.E., Schuster, C.R.: A comparison of cocaine and diethylpropion under the different schedules of drug presentation. In: Ellinwood, E.H., Kilbey, M.M. (eds.): Cocaine and other stimulants, pp. 545–570. New York: Plenum 1976

    Google Scholar 

  • Johanson, C.E., Balster, R.L., Bonese, K.: Self-administration of psychomotor stimulant drugs: the effects of unlimited access. Pharmacol. Biochem. Behav. 4, 45–51 (1976a)

    Article  PubMed  CAS  Google Scholar 

  • Johanson, C.E., Kandel, D.A., Bonese, K.: The effects of perphenazine on self-administration behavior. Pharmacol. Biochem. Behav. 4, 427–433 (1976b)

    Article  PubMed  CAS  Google Scholar 

  • Jones, B.E., Prada, J.A.: Relapse to morphine use in dog. Psychopharmacologia (Berl.) 30, 1–12 (1973)

    Article  CAS  Google Scholar 

  • Kallant, O.J.: The amphetamines: toxicity and addiction. Toronto: University of Toronto Press, 1966

    Google Scholar 

  • Kallant, O.J.: The amphetamines: toxicity and addiction, 2nd ed. Springfield, Ill.: Thomas 1973

    Google Scholar 

  • Kato, M.: Epidemiology of drug dependence in Japan. In: Zarafonetis, C.J.D. (ed.): Drug abuse, pp. 67–70. Philadelphia: Lea & Febiger 1972

    Google Scholar 

  • Keesey, R.E., Goldstein, M.D.: Use of progressive fixed ratio procedures in the assessment of intracranial reinforcement. J. Exp. Anal. Behav. 11, 293–301 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Kelleher, R.T.: Conditioned reinforcement in second-order schedules. J. Exp. Anal. Behav. 9, 475–485 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Kelleher, R.T.: Characteristics of behavior controlled by scheduled injections of drugs. Pharmacol. Rev. 27, 307–323 (1976)

    Google Scholar 

  • Kelleher, R.T., Goldberg, S.R.: Fixed-interval responding under second order schedules of food presentation or cocaine injection. J. Exp. Anal. Behav. 28, 221–231 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Kramer, J.C., Fishman, V.S., Littlefield, D.C.: Amphetamine abuse. Pattern and effects of high doses taken intravenously. J. Amer. Med. Ass. 201, 305–309 (1967)

    Article  CAS  Google Scholar 

  • Masaki, T.: The amphetamine problem in Japan. Wld. Hlth. Org. Techn. Rep. Ser. 102, 14–21 (1956)

    Google Scholar 

  • Pickens, R., Thompson, T.: Self-administration of amphetamine and cocaine by rats. Minutes of the twenty-seventh meeting of the CPDD, pp. 5049–5055. National Academy of Sciences, Washington, D.C. 1967

    Google Scholar 

  • Pickens, R., Thompson, T.: Cocaine-reinforced behavior in rats: effects of reinforcement magnitude and fixed ratio size. J. Pharmacol. Exp. Ther. 161, 122–129 (1968)

    PubMed  CAS  Google Scholar 

  • Risner, M.E.: Intravenous self-administration of d- and L-amphetamine by dog. Eur. J. Pharmacol. 32, 344–348 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Risner, M.E., Jones, B.E.: Self-administration of CNS stimulants by dog. Psychopharma-cologia (Berl.) 43, 207–213 (1975)

    Article  CAS  Google Scholar 

  • Risner, M.E., Jones, B.E.: Intravenous self-administration of cocaine and norcocaine by dogs. Psychopharmacology 71, 83–89 (1980)

    Article  PubMed  CAS  Google Scholar 

  • Sánchez-Ramos, J.R., Schuster, C.R.: Second-order schedules of intravenous drug self-administration in rhesus monkeys. Pharmacol. Biochem. Behav. 7, 443–450 (1977)

    Article  PubMed  Google Scholar 

  • Schuster, C.R., Johanson, C.E.: Behavioral studies of cathinone in monkeys and rats. In: Harris, L.S. (ed.): Problems of drug dependence, 1979. NIDA research monograph 27, pp. 324–325

    Google Scholar 

  • Schuster, C.R., Thompson, T.: Self-administration of and behavioral dependence on drugs. Ann. Rev. Pharmacol. 9, 483–502 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Schuster, C.R., Villarreal, J.E.: Experimental analysis of opioid dependence. In: Efron, D.H. (ed.): Psychopharmacology — a review of progress 1957–1967, pp. 811–828. Washington, D.C.: U.S. Government Printing Office 1968

    Google Scholar 

  • Sjöqvist, F., Tottie, M. (eds.): Abuse of central stimulants. Stockholm: Almqvist & Wiksell 1969

    Google Scholar 

  • Smith, R.C.: Speed and violence: compulsive methamphetamine abuse and criminality in the Haight-Ashbury District. In: Zarefonetis, C.J.D. (ed.): Drug abuse, pp. 435–448. Philadelphia: Lea & Febiger 1972

    Google Scholar 

  • Spealman, R.D.: Behavior maintained by termination of a schedule of self-administered cocaine. Science 204, 1231–1233 (1979)

    Article  PubMed  CAS  Google Scholar 

  • Spealman, R.D., Goldberg, S.R.: Drug self-administration by laboratory animals: control by schedules of reinforcement. Ann. Rev. Pharmacol. Toxicol. 18, 313–339 (1978)

    Article  CAS  Google Scholar 

  • Stretch, R., Gerber, G.J.: A method for chronic intravenous drug administration in squirrel monkeys. Canad. J. Physiol. Pharmacol. 48, 575–581 (1970)

    Article  CAS  Google Scholar 

  • Sydenham, T.: The works, on acute and chronic diseases (1666–1686). Version published in English by Rush, B. in 1815. Facsimile at National Library of Medicine, Washington, D.C.

    Google Scholar 

  • Takahashi, R.N., Singer, G., Oei, T.P.S.: Schedule induced self-injection of D-amphetamine by naive animals. Pharmacol. Biochem. Behav. 9, 857–861 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Tessel, R.E., Woods, J.H.: Fenfluramine and N-ethylamphetamine: comparison of the reinforcing and rate-decreasing actions in the rhesus monkey. Psychopharmacologia (Berl.) 43, 239–244 (1975)

    Article  CAS  Google Scholar 

  • Tessel, R.E., Woods, J.H.: Meta substituted N-ethylamphetamine self-injection responding in the rhesus monkey: estructive-activity relationships. J. Pharmacol. Exp. Ther. 205, 274–281 (1978)

    PubMed  CAS  Google Scholar 

  • Thompson, T., Schuster, C.R.: Morphine self-administration, food-reinforced, and avoidance behaviors in rhesus monkeys. Psychopharmacologia (Berl.) 5, 87–94 (1964)

    Article  CAS  Google Scholar 

  • Villarreal, J.E.: Contributions of laboratory work to the analysis and control of drug dependence. In: Bachly, P.H. (ed.): Drug abuse, data, and debate, pp. 82–103. Springfield, Ill.: Thomas 1970

    Google Scholar 

  • Weeks, J.R.: Experimental morphine addiction: method for automatic intravenous injections in unrestrained rats. Science 138, 143–144 (1962)

    Article  PubMed  CAS  Google Scholar 

  • Wikler, A., Martin, W.R., Pescor, F.T., Eades, C.G.: Factors regulating oral consumption of an opioid (Etonitazine) by morphine-addicted rats. Psychopharmacologia (Berl.) 5, 55–76 (1963)

    Article  CAS  Google Scholar 

  • Wilson, M.C., Schuster, C.R.: The effects of chlorpromazine on psychomotor stimulant self-administration in the rhesus monkey. Psychopharmacologia 26, 115–126 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Wilson, M.C., Schuster, C.R.: Mazindol self-administration in the rhesus monkey. Pharmacol. Biochem. Behav. 4, 207–210 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Wilson, M.C., Hitomi, M., Schuster, C.R.: Psychomotor stimulant self-administration as a function of dosage per injection in the rhesus monkey. Psychopharmacologia 22, 271–281 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Wise, R.A., Yokel, R.A., DeWitt, H.: Both positive reinforcement and conditioned aversion from amphetamine and from apomorphine in rats. Science 191, 1273–1275 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Wise, R.A., Yokel, R.A., Hansson, P.A., Gerber, G.J.: Concurrent intracranial self-stimulation and amphetamine self-administration in rats. Pharmacol. Biochem. Behav. 7, 459–461 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Woods, J.H.: Behavioral effects of cocaine in animals. In: Petersen, R.C., Stillman, R.C. (eds.): Cocaine. 1977. NIDA Research monograph 13, pp. 63–95.

    Google Scholar 

  • Woods, J.H., Tessel, R.E.: Fenfluramine: amphetamine congener that fails to maintain drug-taking behavior in the rhesus monkey. Science 185, 1067–1069 (1974)

    Article  PubMed  CAS  Google Scholar 

  • World Health Organization, Techn. Rep. Ser., No. 577, Evaluation of dependence liability and dependence potential of drugs 1975

    Google Scholar 

  • Yanagita, T.: An experimental framework for evaluation of dependence liability in various types of drugs in monkeys. Bull. Narc. 1, 25–57 (1973)

    Google Scholar 

  • Yanagita, T.: Brief review on the use of self-administration techniques for predicting drug abuse potential. In: Thompson, T., Unna, K. (eds.): Predicting dependence liability of stimulant and depressant drugs, pp. 231–242. Baltimore: University Park 1977

    Google Scholar 

  • Yanagita, T.: Studies on cathinones: cardiovascular and behavioral effects in rats and self-administration experiment in rhesus monkeys. In: Harris, L.S. (ed.): Problems of drug dependence, 1979. NIDA Research monograph 27, pp. 326–327

    Google Scholar 

  • Yanagita, T., Deneau, G.A., Seevers, M.H.: Evaluation of pharmacological agents in the monkey by long-term intravenous self- or programmed-adminiseration. Excerpta Med. Int. Congr. Ser. 87, 453–457 (1965)

    Google Scholar 

  • Young, A.M., Woods, J.H.: Behavior maintained by intravenous injection of codeine, cocaine, and etorphine in the rhesus macaque and the pigtail macaque. Psychopharmacology 70, 263–271 (1980)

    Article  PubMed  CAS  Google Scholar 

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Villarreal, J.E., Salazar, L.A. (1981). The Dependence-Producing Properties of Psychomotor Stimulants. In: Hoffmeister, F., Stille, G. (eds) Psychotropic Agents. Handbook of Experimental Pharmacology, vol 55 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67767-0_16

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