Abstract
Indocyanine green, rose bengal and bromsulphthalein have low biliary excretory rates. They depress bile flow and are strong inhibitors of hepatic mitochondrial respiration, whereas the glutathione conjugate of bromsulphthalein, iodoxamic acid and amaranth have high biliary excretory rates, enhance bile formation and do not inhibit hepatic mitochondrial respiration.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Fischer, E., Varga, F., Gregus, Z., Gógl, Á.: Bile flow and biliary excretion rate of some organic anions in phenobarbital-pretreated rats. Digestion 17, 211–220 (1978)
Gregus, Z., Fischer, E., Varga, F.: Effect of sodium taurocholate on the hepatic transport of bromsulphthalein in rats. Arch. int. Pharmacodyn. 238, 124–133 (1979)
Killenberg, P. G., Hoppel, C. L.: Inhibition of rat liver oxidative phosphorylation by sulfobromophthalein. Mol. Pharmacol. 10, 108–118 (1973)
Laperche, Y., Oudea, M. C., Lostanlen, D.: Toxic effects of indocyanine green on rat liver mitochondria. Toxicol. appl. Pharmacol. 41, 377–387 (1977)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Springer-Verlag
About this paper
Cite this paper
Fischer, E., Gregus, Z., Varga, F. (1980). Effects of Some Cholephilic Agents on Hepatic Mitochondrial Respiration and Biliary Excretion. In: Chambers, P.L., Klinger, W. (eds) Further Studies in the Assessment of Toxic Actions. Archives of Toxicology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67729-8_73
Download citation
DOI: https://doi.org/10.1007/978-3-642-67729-8_73
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-10191-8
Online ISBN: 978-3-642-67729-8
eBook Packages: Springer Book Archive