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Effects of Some Cholephilic Agents on Hepatic Mitochondrial Respiration and Biliary Excretion

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Further Studies in the Assessment of Toxic Actions

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 4))

Abstract

Indocyanine green, rose bengal and bromsulphthalein have low biliary excretory rates. They depress bile flow and are strong inhibitors of hepatic mitochondrial respiration, whereas the glutathione conjugate of bromsulphthalein, iodoxamic acid and amaranth have high biliary excretory rates, enhance bile formation and do not inhibit hepatic mitochondrial respiration.

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References

  • Fischer, E., Varga, F., Gregus, Z., Gógl, Á.: Bile flow and biliary excretion rate of some organic anions in phenobarbital-pretreated rats. Digestion 17, 211–220 (1978)

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  • Gregus, Z., Fischer, E., Varga, F.: Effect of sodium taurocholate on the hepatic transport of bromsulphthalein in rats. Arch. int. Pharmacodyn. 238, 124–133 (1979)

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  • Laperche, Y., Oudea, M. C., Lostanlen, D.: Toxic effects of indocyanine green on rat liver mitochondria. Toxicol. appl. Pharmacol. 41, 377–387 (1977)

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© 1980 Springer-Verlag

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Fischer, E., Gregus, Z., Varga, F. (1980). Effects of Some Cholephilic Agents on Hepatic Mitochondrial Respiration and Biliary Excretion. In: Chambers, P.L., Klinger, W. (eds) Further Studies in the Assessment of Toxic Actions. Archives of Toxicology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67729-8_73

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  • DOI: https://doi.org/10.1007/978-3-642-67729-8_73

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10191-8

  • Online ISBN: 978-3-642-67729-8

  • eBook Packages: Springer Book Archive

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