Effects of Some Cholephilic Agents on Hepatic Mitochondrial Respiration and Biliary Excretion

  • E. Fischer
  • Z. Gregus
  • F. Varga
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 4)

Abstract

Indocyanine green, rose bengal and bromsulphthalein have low biliary excretory rates. They depress bile flow and are strong inhibitors of hepatic mitochondrial respiration, whereas the glutathione conjugate of bromsulphthalein, iodoxamic acid and amaranth have high biliary excretory rates, enhance bile formation and do not inhibit hepatic mitochondrial respiration.

Key words

Cholephilic agents Bile secretion Mitochondrial respiration Amaranth Bromsulphthalein Glutathione conjugate of bromsulphthalein Bromcresol green Eosine Indocyanine green Iodoxamic acid Rose bengal 

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References

  1. Fischer, E., Varga, F., Gregus, Z., Gógl, Á.: Bile flow and biliary excretion rate of some organic anions in phenobarbital-pretreated rats. Digestion 17, 211–220 (1978)PubMedCrossRefGoogle Scholar
  2. Gregus, Z., Fischer, E., Varga, F.: Effect of sodium taurocholate on the hepatic transport of bromsulphthalein in rats. Arch. int. Pharmacodyn. 238, 124–133 (1979)PubMedGoogle Scholar
  3. Killenberg, P. G., Hoppel, C. L.: Inhibition of rat liver oxidative phosphorylation by sulfobromophthalein. Mol. Pharmacol. 10, 108–118 (1973)Google Scholar
  4. Laperche, Y., Oudea, M. C., Lostanlen, D.: Toxic effects of indocyanine green on rat liver mitochondria. Toxicol. appl. Pharmacol. 41, 377–387 (1977)PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • E. Fischer
    • 1
  • Z. Gregus
    • 1
  • F. Varga
    • 1
  1. 1.Department of PharmacologyUniversity Medical School of PécsPécsHungary

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