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Acrylonitrile Metabolism in the Rat

  • Conference paper
Further Studies in the Assessment of Toxic Actions

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 4))

Abstract

Acrylonitrile (AN) is metabolized by an oxidative pathway via glycidonitrile and glycolaldehyde cyanohydrin to cyanide (CN−), which is transformed to thiocyanate. The major route of AN metabolism (more than 2/3), however, proceeds via cyanoethylation of glutathione, to N-ace-tyl-S-(2-cyanoethyl)cysteine (AN-mercapturic acid) as a final product.

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References

  • Barnsley, E. A., Thomson, A. E. R., Young, L.: Biochemical studies on toxic agents. 15. The biosynthesis of ethylmercapturic acid. Biochem. J. 90, 588–596 (1964)

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  • Brieger, H., Rieders, F., Hodes, W. A.: Acrylonitrile: spectrophotometric determination, acute toxicity, and mechanism of action. Arch. Ind. Hyg. 6, 128–140 (1952)

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  • Bruce, R. B., Howard, J. W., Hanzal, R. F.: Determination of cyanide, thiocyanate, and alpha-hydroxynitriles in plasma or serum. Anal. Chem. 27, 1346–1347 (1955)

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Author information

Authors and Affiliations

  1. Institute of Hygiene and Epidemiology, Šrobárova 48, 10042, Prague 10, Czechoslovakia

    J. Kopecký, I. Gut, J. Nerudová, D. Zachardová & V. Holeček

  2. Investigation and Uses of Radioisotopes, Institute of Production, Prague, Czechoslovakia

    J. Filip

Authors
  1. J. Kopecký
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  2. I. Gut
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  3. J. Nerudová
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  4. D. Zachardová
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  5. V. Holeček
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  6. J. Filip
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers

  2. Institut für Pharmakologie und Toxikologie, Friedrich-Schiller-Universität Jena, DDR-6900, Jena, GDR

    Wolfgang Klinger

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© 1980 Springer-Verlag

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Kopecký, J., Gut, I., Nerudová, J., Zachardová, D., Holeček, V., Filip, J. (1980). Acrylonitrile Metabolism in the Rat. In: Chambers, P.L., Klinger, W. (eds) Further Studies in the Assessment of Toxic Actions. Archives of Toxicology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67729-8_66

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  • DOI: https://doi.org/10.1007/978-3-642-67729-8_66

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10191-8

  • Online ISBN: 978-3-642-67729-8

  • eBook Packages: Springer Book Archive

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