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Thymocyte Stimulating Activity of the Serum of Rats in the Early Phase After 2-Acetylaminofluorene (AAF)-Treatment

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Further Studies in the Assessment of Toxic Actions

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 4))

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Abstract

The serum of rats collected at various time intervals after application of a single dose of 2-acetylaminofluorene (AAF) stimulates the incorporation of 3H-thymidine into the DNA of cultured thymocytes of rats, mice and hamsters. This reaction shows a clear dose-response relationship. The serum activity is dialysable and relatively thermostable.

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References

  • Bräuer, R., Danz, M., Urban, H., Waldmann, G.: Stimulation of thymocytes in vitro by serum of 2-acetylaminofluorene (AAF)-treated rats. Exp. Path. 17, 439–445 (1979)

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  • Danz, M., Urban, H., Bräuer, R., Schmidt, A.: Growth stimulation following serum transfer from carcinogen-treated donors to normal rats: a new aspect of early carcinogen actions. Exp. Path. 16, 23–35 (1978a)

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Author information

Authors and Affiliations

  1. Institute of Pathology, Friedrich Schiller University, 6900, Jena, GDR

    R. Bräuer, M. Danz, H. Urban & G. Waldmann

Authors
  1. R. Bräuer
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  2. M. Danz
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  3. H. Urban
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  4. G. Waldmann
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers

  2. Institut für Pharmakologie und Toxikologie, Friedrich-Schiller-Universität Jena, DDR-6900, Jena, GDR

    Wolfgang Klinger

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© 1980 Springer-Verlag

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Bräuer, R., Danz, M., Urban, H., Waldmann, G. (1980). Thymocyte Stimulating Activity of the Serum of Rats in the Early Phase After 2-Acetylaminofluorene (AAF)-Treatment. In: Chambers, P.L., Klinger, W. (eds) Further Studies in the Assessment of Toxic Actions. Archives of Toxicology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67729-8_33

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  • DOI: https://doi.org/10.1007/978-3-642-67729-8_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10191-8

  • Online ISBN: 978-3-642-67729-8

  • eBook Packages: Springer Book Archive

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