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Arzneimittelstoffwechsel bei chronischer Urämie

  • Conference paper
Pharmakotherapie bei Niereninsuffizienz

Zusammenfassung

Lipophile Pharmaka können nur nach metabolischer Umwandlung in wasserlöslichere Produkte aus dem Organismus eliminiert werden. Die wichtigsten dabei stattfindenden Abbaureaktionen sind in Tabelle 1 angegeben. Hauptort für den Arzneimittelabbau ist das endoplasmatische Retikulum der Leber, jedoch finden einzelne Reaktionen auch in Niere, Lunge, Darm und andernorts statt.

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Literatur

  1. Bennett WM, Singer I, Golper T, Feig P, Coggins C (1977) Ann Int Med 86:754

    PubMed  CAS  Google Scholar 

  2. Reidenberg MM (1975) Clin Nephrol 4:83

    PubMed  CAS  Google Scholar 

  3. Leber HW (1976) Med Klin 71:1321

    PubMed  CAS  Google Scholar 

  4. Reidenberg MM (1977) Am J Med 62:482

    Article  PubMed  CAS  Google Scholar 

  5. Lichter M, Black M, Arias JM (1973) J Pharmacol Exp Ther 187:612

    PubMed  CAS  Google Scholar 

  6. Maddocks IL (1976) Proc Europ Dialys, Transpl Ass 13:624

    Google Scholar 

  7. Held H, Enderle C (1976) Clin Nephrol 6:388

    PubMed  CAS  Google Scholar 

  8. Leber HW, Harders A, Schütterle G (1972) Klin Wochenschr 50:1092

    Article  PubMed  CAS  Google Scholar 

  9. Jungbluth H (1970) Habilitationsschrift, Frankfurt (M)

    Google Scholar 

  10. Fabre J (1972) Schweiz Med Wochenschr 102:251

    PubMed  CAS  Google Scholar 

  11. Dettli L, Spring S, Ryter S (1971) Acta Pharmacol (Kbh) 29 Suppl. 3:211

    Google Scholar 

  12. Gillette JR (1971) Ann N Y Acad Sci 179:43

    Article  PubMed  CAS  Google Scholar 

  13. Reidenberg MM, Odar-Cederlof J, Bahr C von, Borga OK, Sjöquist F (1971) N Engl J Med 285:264

    Article  PubMed  CAS  Google Scholar 

  14. Reidenberg MM, Affrime M (1973) Ann N Y Acad Sci 226:115

    Article  PubMed  CAS  Google Scholar 

  15. Andreasen F, Jullobsen P (1974) Acta Pharmacol Toxicol 34:49

    Google Scholar 

  16. Ehrnebo M, Odar-Lederlöf J (1975) Eur J Clin Pharmacol 8:445

    Article  PubMed  CAS  Google Scholar 

  17. Kramer P, Köthe E, Saul J, Scheler F (1974) Eur J Clin Invest 4:53

    Article  PubMed  CAS  Google Scholar 

  18. Thurman RG, Scholz R (1969) The Pharmacologist 11:260

    Google Scholar 

  19. Leber HW (1973) Habilitationsschrift, Giessen

    Google Scholar 

  20. Leber HW, Schütterle G (1972) Kidney Int 2:152

    Article  PubMed  CAS  Google Scholar 

  21. Leber HW, Streitzig P, Kayser M, Schütterle G (1971) Klin Wochenschr 49:944

    Article  PubMed  CAS  Google Scholar 

  22. Leber HW (1972) Z Klin Chem Klin Biochem 10:543

    CAS  Google Scholar 

  23. Leber HW, Gleumes L, Schütterle G (1973) Verh Dtsch Ges Inn Med 79:711

    PubMed  CAS  Google Scholar 

  24. Conney AH (1967) Pharmacol Rev 19:317

    PubMed  CAS  Google Scholar 

  25. Leber HW, Gleumes L, Schütterle G (1978) Kidney Int 13 Suppl 8:44

    Google Scholar 

  26. Leber HW, Streitzig P, Kayser M, Schütterle G (1971) Verh Dtsch Ges Nephrol S 75

    Google Scholar 

  27. Meergaard H, Nielsen B, Faubry V, Christensen DH, Nielsen OF (1971) Scand J Urol Nephrol 5:141

    Article  Google Scholar 

  28. Fine A, Summer D (1974) Proc Eur Dialysis Transpl Ass Abstr p 20

    Google Scholar 

  29. Letteri JW, Mellk H, Louis S, Kutt H, Durante P, Glazko A (1971) N Engl J Med 285:648

    Article  PubMed  CAS  Google Scholar 

  30. Balasubramaniam K, Mawer GE, Pohl JEF, Simons PIG (1972) Br J Pharmacol 45:360

    PubMed  CAS  Google Scholar 

  31. Mundel JW, Richards RK (1954) Anesthoisology 15:333

    Article  Google Scholar 

  32. Richards RK, Raylor JD, Kueter KE (1953) J Pharmacol Exp Ther 108:461

    PubMed  CAS  Google Scholar 

  33. Fillastre JP, Dubois D, Brunelle P (1973) In: Zanetti A, Enrico M (ed) Modern aspects in the treatment of hypertension. Boehringer, Ingelheim p 81

    Google Scholar 

  34. Elion GB, Ts’ai-Fan Yü (1968) Am J Med 45:69

    Article  PubMed  CAS  Google Scholar 

  35. Ohnhaus EE (1973) Br J Pharmacol 47:620

    Google Scholar 

  36. Thompson FD, Joekes AM, Foulkes DM (1972) Br Med J 2:434

    Article  PubMed  CAS  Google Scholar 

  37. Kessler KM, Lowenthal DT, Gibson T, Warner H, Reidenberg MM (1974) N Engl J Med 290:706

    Article  PubMed  CAS  Google Scholar 

  38. Glogner P, Lange H, Pfab R (1968) Med Welt (N F) 19:2876

    Google Scholar 

  39. Reidenberg MM, Klosterbauer H, Adams WP (1969) Metabolism 18:209

    Article  PubMed  CAS  Google Scholar 

  40. Baethke B, Golde G, Gabl G (1972) Eur J Clin Pharmacol 4:233

    Article  Google Scholar 

  41. Myrhe E, Stenbaek Ö, Hansen T (1972) Scand J Clin Lab Med 29:195

    Article  Google Scholar 

  42. Ogg CS, Toseland PA, Cameron JS (1968) Br Med J 2:283

    Article  PubMed  CAS  Google Scholar 

  43. Lowenthal DT, Briggs WA, Levy G (1974) J Clin Invest 54:1221

    Article  PubMed  CAS  Google Scholar 

  44. Kunin CM, Glazko AJ, Finland M (1959) J Clin Invest 38:1498

    Article  PubMed  CAS  Google Scholar 

  45. Traeger A, Stein G, Kunze M, Zaumseil J (1972) Int J Clin Pharmacol 63:237

    Google Scholar 

  46. Gibson TG, Atkinson AJ jr, Matusik E, Nelson LE, Briggs WA (1977) Kidney Int 12:422

    Article  PubMed  CAS  Google Scholar 

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© 1980 Springer-Verlag Berlin Heidelberg

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Leber, H.W. (1980). Arzneimittelstoffwechsel bei chronischer Urämie. In: Heidland, A., Wetzels, E. (eds) Pharmakotherapie bei Niereninsuffizienz. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67676-5_3

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  • DOI: https://doi.org/10.1007/978-3-642-67676-5_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10101-7

  • Online ISBN: 978-3-642-67676-5

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