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Effects of Adrenergic Activators and Inhibitors on the Sweat Glands

  • D. Robertshaw
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 54 / 2)

Abstract

Sweat glands have been defined as all those cutaneous glands other than sebaceous glands that produce a secretion onto the surface of the skin. This loose definition encompasses a wide variety of structures with a broad range of functions. Some, such as the dermal glands of the hippopotamus or the nasal disc of the pig, have never been identified as sweat glands, whereas other glands are so specialized that it is difficult to decide how they might be classified. On a purely anatomical and embryological basis Bligh (1967) coined the terms epitrichial to refer to glands associated with hair follicles, and atrichial for those that open onto the epidermal surface independent of hair follicle units. Schiefferdecker (1917, 1922) classified glands associated with hair follicles as apocrine and those that have a duct which spirals through the epidermis and are independent of hair follicles or sebaceous glands as eccrine. This is the more conventional terminology although it is based on a suggested mode of secretion that is probably erroneous (Jenkinson, 1967). There does, however, appear to be a physiologic distinction between the two types of glands since eccrine glands are innervated largely by cholinergic nerves and apocrine glands by adrenergic nerves. Thus it is possible to examine sudomotor transmission alone without having to classify them on the basis of structure or function of the gland. In fact, there is considerable functional overlap. For example, in man and many primates, eccrine glands are concerned with thermoregulation, whereas in cattle and horses apocrine glands serve this function. Likewise, the sweat glands on the foot pad of the cat and dog aid frictional resistance and are eccrine, whereas those on the feet of the koala bear are apocrine.

Keywords

Sweat Gland Heat Exposure Eccrine Sweat Gland Apocrine Gland Adrenergic Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Allen, J.A., Roddie, I.C.: The role of circulating catecholamines in sweat production in man. J. Physiol. (Lond.) 227, 801–814 (1972)Google Scholar
  2. Allen, J.A., Jenkinson, D.J., Roddie, I.C.: The effect of β-adrenoceptor blockade on human sweating. Br. J. Pharmacol. 47, 487–497 (1972)Google Scholar
  3. Allen, T.E., Bligh, J.: A comparative study of the temporal patterns of cutaneous water vapour loss from some domesticated mammals with epitrichial sweat glands. Comp. Biochem. Physiol. 31, 347–363 (1969)PubMedCrossRefGoogle Scholar
  4. Aoki, T.: Stimulation of the sweat glands in the hairy skin of the dog by adrenaline, noradrenaline, mecholyl and pilocarpine. J. Invest. Dermatol. 24, 545–556 (1955)PubMedCrossRefGoogle Scholar
  5. Aoki, T.: The skin of primates. IX. Observations on the functional activity of the sweat glands in Nycticebus coucang and Perodicticus potto. J. Invest. Dermatol. 39, 115–122 (1962 a)PubMedGoogle Scholar
  6. Aoki, T.: Stimulation of human axillary apocrine sweat glands by cholinergic agents. J. Invest. Dermatol. 38, 41–44 (1962 b)PubMedGoogle Scholar
  7. Aoki, T., Wada, M.: Functional activity of the sweat glands in the hairy skin of the dog. Science 114, 123–124 (1951)PubMedCrossRefGoogle Scholar
  8. Barcroft, H., Swan, H.J.C.: Sympathetic control of human blood vessels. In: Monograph of Physiological Society, No. 1. L.E. Bayliss, W. Feldberg, A.L. Hodgkin (eds.). London: Arnold 1953Google Scholar
  9. Bell, F.R., Evans, C.L.: Sweating responses in the horse. J. Physiol. (Lond.) 134, 421–426 (1956)Google Scholar
  10. Bell, M.: The ultrastructure of human axillary apocrine glands after epinephrine injection. J. Invest. Dermatol. 63, 147–159 (1974)PubMedCrossRefGoogle Scholar
  11. Bell, M., Montagna, W.: Innervation of sweat glands in horses and dogs. Br. J. Dermatol. 86, 160–163 (1972)PubMedCrossRefGoogle Scholar
  12. Bligh, J.: A thesis concerning the processes of secretion and discharge of sweat. Environ. Res. 1, 28–45 (1967)PubMedCrossRefGoogle Scholar
  13. Boura, A.L.A., Green, A.F.: Adrenergic neurone blockade and other acute effects caused by N-benzyl-N′N″-dimethylguanidine and its ortho chloro derivative. Br. J. Pharmacol. 20, 36–55 (1963)Google Scholar
  14. Brunaud, M., Pitre, J.: Existe-t-il de l’adrénaline dans la sueur du cheval? Bull. Acad. Vet. France 18, 339–347 (1945)Google Scholar
  15. Chalmers, T.M., Keele, C.A.: Physiological significance of the sweat response to adrenaline in man. J. Physiol. (Lond.) 114, 510–514 (1951)Google Scholar
  16. Chalmers, T.M., Keele, C.A.: The nervous and chemical control of sweating. Br. J. Dermatol. 64, 43–54 (1952)PubMedCrossRefGoogle Scholar
  17. Collins, K.J., Sargent, F., Weiner, J.S.: Excitation and depression of eccrine sweat glands by acetylcholine, acetyl-β-methylcholine and adrenaline. J. Physiol. (Lond.) 148, 592–614 (1959)Google Scholar
  18. Cotton, D.W.K., Van Hasselt, P.: Sweating on the hairy surface of the beagle. J. Invest. Dermatol. 59, 313–316 (1972)PubMedCrossRefGoogle Scholar
  19. Dale, H.H., Feldberg, W.: The chemical transmission of secretory impulses to the sweat glands of the cat. J. Physiol. (Lond.) 82, 121–128 (1934)Google Scholar
  20. Dawson, T.J., Robertshaw, D., Taylor, C.R.: Sweating in the red kangaroo: stimulation during exercise but not in the heat. Am. J. Physiol. 224, 494–498 (1974)Google Scholar
  21. Ellis, R.A., Montagna, W.: The sweat glands of the Lorisidae. In: Evolutionary and Genetic Biology of Primates. J. Buettner-Janusch (ed.). Vol. 1. New York: Academic Press 1963Google Scholar
  22. Evans, C.L., Smith, D.F.G.: Sweating responses in the horse. Proc. R. Soc. Lond. [Biol.] 145, 61–83 (1956)CrossRefGoogle Scholar
  23. Falck, B.: Observations on the possibilities of the cellular localization of monoamines by a fluorescence method. Acta Physiol. Scand. 56, Suppl. 197 (1962)Google Scholar
  24. Ferguson, K.A., Dowling, D.F.: The function of cattle sweat glands. Aust. J. Agr. Res. 6, 641–644 (1955)CrossRefGoogle Scholar
  25. Findlay, J.D., Robertshaw, D.: The role of the sympathoadrenal system in the control of sweating in the ox (Bostaurus). J. Physiol. (Lond.) 179, 285–297 (1965)Google Scholar
  26. Foster, K.G.: Response of the cats’ pad eccrine sweat glands to intravascular injections of catecholamines. J. Physiol. (Lond.) 195, 331–337 (1968)Google Scholar
  27. Foster, K.G., Weiner, J.S.: Effects of cholinergic and adrenergic blocking agents on the activity of the eccrine sweat glands. J. Physiol. (Lond.) 210, 883–895 (1970)Google Scholar
  28. Foster, K.G., Ginsburg, J., Weiner, J.S.: Role of circulating catecholamines in human eccrine sweat gland control. Clin. Sci. 39, 823–832 (1970)PubMedGoogle Scholar
  29. Ginsburg, J., Paton, A.: Effects in man of insulin hypoglycaemia after adrenalectomy. J. Physiol. (Lond.) 133, 59–60P (1956)Google Scholar
  30. Gordon, B.I., Maibach, H.I.: Effect of systemically administered epinephrine on palmar sweating. Arch. Dermatol. 92, 192–194 (1965)CrossRefGoogle Scholar
  31. Gubbins, S., Johnson, K.G.: Evaporative water loss in the wallaby (Protemnodon rufogrisea). J. Physiol. (Lond.) 226, 110–111P (1972)Google Scholar
  32. Haimovici, H.: Evidence for adrenergic sweating in man. J. Appl. Physiol. 2, 512–521 (1950)PubMedGoogle Scholar
  33. Harrison, J., Mackinnon, P.C.B.: Central effect of epinephrine and norepinephrine on the palmar sweat index. Am. J. Physiol. 204, 785–788 (1963)PubMedGoogle Scholar
  34. Hayashi, H.: Functional activity of the sweat glands in the hairy skin of the sheep. Tohoku J. Exp. Med. 94, 361–375 (1968)Google Scholar
  35. Hayashi, H., Nakagawa, T.: Functional activity of the sweat glands of the albino rat. J. Invest. Dermatol. 41, 365–367 (1963)PubMedCrossRefGoogle Scholar
  36. Hofmeyr, H.S., Guidry, A.J., Waltz, F.A.: Effects of temperature and wool length on surface and respiratory evaporative losses of sheep. J. Appl. Physiol. 26, 517–523 (1969)PubMedGoogle Scholar
  37. Hurley, H.J., Witkowski, J.A.: Mechanism of epinephrine-induced eccrine sweating in human skin. J. Appl. Physiol. 16, 652–654 (1961)PubMedGoogle Scholar
  38. Ichibashi, T.: Effect of drugs on the sweat glands by cataphoresis and effective method for suppression of local sweating. J. Orient. Med. 25, 1401 (1936)Google Scholar
  39. Ikai, K., Hasegawa, Y.: Adrenaline sweating. In: Advances in Climatic Physiology. S. Itoh, K. Ogata, H. Yoshimura (eds.) Tokyo: Igaku Shoin 1972Google Scholar
  40. Ingram, D.L.: Stimulation of cutaneous glands in the pig. J. Comp. Pathol. 77, 93–98 (1967)PubMedCrossRefGoogle Scholar
  41. Ingram, D.L., McLean, J.A., Whittow, G.C.: The effect of heating the hypothalamus and the skin on the rate of moisture vaporization from the skin of the ox (Bos taurus). J. Physiol. (Lond.) 169, 394–403 (1963)Google Scholar
  42. Iversen, L.L.: The uptake and storage of noradrenaline in sympathetic nerves. Cambridge: Cambridge University Press 1967Google Scholar
  43. Iwabuchi, T.: General sweating on the hairy skin of the dog and its mechanisms. J. Invest. Dermatol. 49, 61–70 (1967)PubMedGoogle Scholar
  44. Jenkinson, D.McE.: On the classification of sweat glands and the question of the existence of an apocrine secretory process. Br. Vet. J. 123, 311–316 (1967)PubMedGoogle Scholar
  45. Jenkinson, D.McE., Blackburn, P.S.: The distribution of nerves, monoamine oxidase and cholinesterase in the skin of the sheep and goat. J. Anat. 101, 333–341 (1967)PubMedGoogle Scholar
  46. Jenkinson, D.McE., Blackburn, P.S.: The distribution of nerves, monoamine oxidase and cholinesterase in the skin of the horse. Res. Vet. Sci. 9, 165–169 (1968)PubMedGoogle Scholar
  47. Jenkinson, D.McE., Robertshaw, D.: Studies on the nature of sweat gland “fatigue” in the goat. J. Physiol. (Lond.) 212, 455–465 (1971)Google Scholar
  48. Jenkinson, D.McE., Montgomery, I., Elder, H.Y.: Studies on the nature of the peripheral sudomotor control mechanism. J. Anat. 125, 625–639 (1978)PubMedGoogle Scholar
  49. Jenkinson, D.McE., Sengupta, B.P., Blackburn, P.S.: The ditribution of nerves, monoamine oxidase and cholinesterase in the skin of cattle. J. Anat. 100, 593–613 (1966)PubMedGoogle Scholar
  50. Johnson, K.G.: The discharge of sweat in Welsh Mountain sheep. J. Physiol. (Lond.) 215, 743–753 (1971)Google Scholar
  51. Johnson, K.G.: Sweat gland function in isolated perfused skin. J. Physiol. (Lond.) 250, 633–649 (1975)Google Scholar
  52. Kernen, R., Brun, R.: Expériences sur la transpiration. V. Examens pharmacodynamiques au niveau de la gland sudoripare de l’homme. Dermatologica 106, 1–13 (1953)PubMedCrossRefGoogle Scholar
  53. Kimura, S., Aoki, T.: Functional activity of the apocrine sweat gland in the goat. Tohoku J. Exp. Med. 76, 8–22 (1962)Google Scholar
  54. Kisin, E.E.: A method of pharmacological study of the sweating function of the skin in situ. Vestn. Venerol. i Dermatol. 5, 27–31 (1948)Google Scholar
  55. Kuno, Y.: The mechanism of human sweat secretion. Proc. Int. Union Physiol. Sci. 4, 3–16 (1965)Google Scholar
  56. Lands, A.M., Arnold, A., Mc Auliff, J.P., Luduena, F.P., Brown, T.G., Jr.: Differentiation of receptor systems activated by sympathomimetic amines. Nature 214, 597–598 (1967)PubMedCrossRefGoogle Scholar
  57. Lloyd, D.P.C.: Response of cholinergically innervated sweat glands to adrenaline and nor-adrenaline. Nature 184, 277–2078 (1959)PubMedCrossRefGoogle Scholar
  58. Lloyd, D.P.C.: Action of phenoxybenzamine on neural and humoral activation of sweat glands. J. Physiol. (Lond.) 169, 116–117P (1963)Google Scholar
  59. Lloyd, D.P.C.: Actions of guanethidine and bretylium on transmission to sweat glands in the cat. J. Physiol. (Lond.) 175, 74P (1964)Google Scholar
  60. Lloyd, D.P.C.: Effect of phenoxybenzamine on neural and humoral control of sweat glands. Proc. Natl. Acad. Sci. USA 59, 816–20 (1968)PubMedCrossRefGoogle Scholar
  61. Mabon, R.M.: Two possible catecholamine metabolites in the secretion from ox skin. Res. Vet. Sci. 11, 287–288 (1970)PubMedGoogle Scholar
  62. Mellinkoff, S.M., Sonnenschein, R.R.: Identity of sweat glands stimulated by heat, epinephrine and acetylcholine. Science 120, 997–998 (1954)PubMedCrossRefGoogle Scholar
  63. Myers, R.D., Yaksh, T.L.: Control of body temperature in the unanaesthetised monkey by cholinergic and aminergic systems in the hypothalamus. J. Physiol. (Lond.) 202, 483–500 (1969)Google Scholar
  64. Nakamura, Y., Hatanaka, K.: The effect of denervation of the cat’s sweat glands on their responsiveness to adrenaline, nicotine and mecholyl. Tohoku J. Exp. Med. 68, 225–237 (1958)Google Scholar
  65. Ogawa, T.: Effects of subcutaneously administered adrenaline on human eccrine sweating, with special reference to the physiological significance of the adrenergic sweating mechanism. Jap. J. Physiol. 26, 517–528 (1976a).CrossRefGoogle Scholar
  66. Ogawa, T.: Effects of intradermal adrenaline on human eccrine sweating, with special reference to its possible interaction with the cholinergic mechanism. J. Aichi Med. Univ. Ass. 4, 163–172 (1976b)Google Scholar
  67. Prout, B.J., Wardell, W.M.: Sweating and peripheral blood flow in patients with phaeochromocytoma. Clin. Sci. 36, 109–117 (1969)PubMedGoogle Scholar
  68. Robertshaw, D.: The pattern and control of sweating in the sheep and the goat. J. Physiol. (Lond.) 198, 531–539 (1968)Google Scholar
  69. Robertshaw, D.: Neural and humoral control of apocrine glands. J. Invest. Dermatol. 63, 160–167 (1974)PubMedCrossRefGoogle Scholar
  70. Robertshaw, D.: Catecholamines and control of sweat glands. In: Handbook of Physiology, Endocrinology VI. H. Blaschko, G. Sayers, A.D. Smith (eds.) Washington, D.C.: American Physiological Society 1975Google Scholar
  71. Robertshaw, D., Taylor, C.R.: A comparison of sweat gland activity in eight species of East African bovids. J. Physiol. (Lond.) 203, 135–143 (1969 a)Google Scholar
  72. Robertshaw, D., Taylor, C.R.: Sweat gland function of the donkey (Equus asinus). J. Physiol. (Lond.) 205, 79–89 (1969 b)Google Scholar
  73. Robertshaw, D., Taylor, C.R., Mazzia, L.M.: Sweating in primates: secretion by adrenal medulla during exercise. Am. J. Physiol. 224, 678–681 (1973)PubMedGoogle Scholar
  74. Rollinson, D.H.L., Injidi, M.H., Jenkinson, D.McE.: The distribution of nerves, monoamine oxidase and Cholinesterase in the skin of the camel. Res. Vet. Sci. 13, 304–305 (1972)PubMedGoogle Scholar
  75. Sato, F., Burgers, M., Sato, K.: Some characteristics of adrenergic human eccrine sweating. Experientia 30, 40–41 (1974)CrossRefGoogle Scholar
  76. Sato, K.: Sweat induction from an isolated eccrine sweat gland. Am. J. Physiol. 225, 1147–1152 (1973)PubMedGoogle Scholar
  77. Schiefferdecker, P.: Die Hautdrüsen des Menschen und der Säugetiere, ihre biologische und rassenatomische Bedeutung, sowie die Muscularis sexualis. Biol. Zentr. 37, 534–562 (1917)Google Scholar
  78. Schiefferdecker, P.: Die Hautdrüsen des Menschen und der Säugetiere, ihre biologische und rassenatomische Bedeutung, sowie die Muscularis sexualis. Zoologica 72, 1–154 (1922)Google Scholar
  79. Schmidt-Nielsen, K., Schmidt-Nielsen, B., Jarnum, S.A., Houpt, T.R.: Body temperature of the camel and its relation to water economy. Am. J. Physiol. 188, 103–112 (1957)PubMedGoogle Scholar
  80. Shanks, R.G., Hadden, D.R., Lowe, D.C., Mc Devitt, D.G., Montgomery, D.A.D.: Controlled trial of propranolol in thyrotoxicosis. Lancet i, 993–994 (1969)Google Scholar
  81. Shelley, W.B.: Apocrine sweat. J. Invest. Dermatol. 17, 255 (1951)Google Scholar
  82. Shelley, W.B., Hurley, H.J.: Methods of exploring human apocrine gland physiology. Arch. Dermatol. Syphilol. 66, 165–161, 172–179 (1952)Google Scholar
  83. Silver, A., Montagna, W., Karacan, I.: Age and sex differences in spontaneous, adrenergic and cholinergic human sweating. J. Invest. Dermatol. 43, 255–266 (1964)Google Scholar
  84. Snow, D.H.: Identification of the receptor involved in adrenaline mediated sweating in the horse. Res. Vet. Sci. 23, 246–247 (1977)PubMedGoogle Scholar
  85. Sonnenschein, R.R., Kobrin, H., Janowitz, H.D., Grossman, M.I.: Stimulation and inhibition of human sweat glands by intradermal sympathomimetic agents. J. Appl. Physiol. 3, 573–581 (1951)PubMedGoogle Scholar
  86. Tanaka, I., Nakamura, T.: Action of adrenaline, noradrenaline, and isopropylnoradrenaline on the sweat glands in young healthy men. Kumamoto Med. J. 8, 26–28 (1955)Google Scholar
  87. Uno, H.: Sympathetic innervation of the sweat glands and piloarrector muscles of macaques and human beings. J. Invest. Dermatol. 69, 112–120 (1977)PubMedCrossRefGoogle Scholar
  88. Van Beaumont, W., Bullard, R.W.: Sweating: exercise stimulation during circulatory arrest. Science 152, 1521–1523 (1966)PubMedCrossRefGoogle Scholar
  89. Vogt, M.: Influence of circulating catecholamines on the central nervous system. In: Handbook of Physiology, Vol. VI, Endocrinology. H. Blaschko, G. Sayers, A.D. Smith (eds.). Washington, D.C.: American Physiological Society 1975Google Scholar
  90. Wada, F.: Effects of exercise on excitability of local sweat glands. Japan J. Physical Fitness. 5, 246–247 (1955)Google Scholar
  91. Wada, M.: Sudorific action of adrenaline on the human sweat glands and determination of their excitability. Science 111, 376–377 (1950)PubMedCrossRefGoogle Scholar
  92. Waites, G.M.H., Voglmayr, J.K.: The functional activity and control of the apocrine sweat glands of the scrotum of the ram. Aust. J. Agr. Res. 14, 839–851 (1963)CrossRefGoogle Scholar
  93. Wolf, J.E., Maibach, H.I.: Palmar eccrine sweating-the role of adrenergic and cholinergic mediators. Br. J. Dermatol. 91, 439–446 (1974)PubMedCrossRefGoogle Scholar

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  • D. Robertshaw

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