Regional Myocardial Perfusion Assessed by Nitrogen-13 Labeled Ammonia and Positron Emission Computerized Axial Tomography

  • H. R. Schelbert
  • M. E. Phelps
  • E. J. Hoffman
  • S.-C. Huang
Conference paper


With the recent development of positron emission computerized axial tomography (PCT), cross-sectional imaging of the heart has become possible [1]. These cross-sectional images reflect quantitatively the distribution of radioactive indicator concentrations in the myocardium and can be thought of as “in vivo” autoradiographs. Potentially, PCT provides a nontraumatic means for quantifying regional myocardial perfusion. The usefulness of 13NH3 as a myocardial perfusion imaging agent suitable for PCT has been suggested [2–5], although the relation of 13NH3 uptake to myocardial blood flow has not yet been examined in quantitative terms. Characterization of this relationship including the study of myocardial 13NH3 uptake during the hyperemia of exercise is particularly important for the noninvasive assessment of coronary artery disease [6,7]. Therefore, the goal of this study was to examine the realtionship between myocardial perfusion and 13NH3 uptake over a wide range of coronary blood flow and to examine the accuracy of quantifying noninvasively by PCT myocardial 13NH3 tissue concentration and, hence, regional myocardial perfusion.


Myocardial Perfusion Left Atrium Left Anterior Descend Myocardial Blood Flow Coronary Blood Flow 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • H. R. Schelbert
    • 1
    • 2
  • M. E. Phelps
    • 1
    • 2
  • E. J. Hoffman
    • 1
    • 2
  • S.-C. Huang
    • 1
    • 2
  1. 1.Division of Nuclear MedicineUCLA School of MedicineLos AngelesUSA
  2. 2.Laboratory of Nuclear Medicine and Radiation BiologyLos AngelesUSA

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