Regional Myocardial Perfusion Assessed by Nitrogen-13 Labeled Ammonia and Positron Emission Computerized Axial Tomography
With the recent development of positron emission computerized axial tomography (PCT), cross-sectional imaging of the heart has become possible . These cross-sectional images reflect quantitatively the distribution of radioactive indicator concentrations in the myocardium and can be thought of as “in vivo” autoradiographs. Potentially, PCT provides a nontraumatic means for quantifying regional myocardial perfusion. The usefulness of 13NH3 as a myocardial perfusion imaging agent suitable for PCT has been suggested [2–5], although the relation of 13NH3 uptake to myocardial blood flow has not yet been examined in quantitative terms. Characterization of this relationship including the study of myocardial 13NH3 uptake during the hyperemia of exercise is particularly important for the noninvasive assessment of coronary artery disease [6,7]. Therefore, the goal of this study was to examine the realtionship between myocardial perfusion and 13NH3 uptake over a wide range of coronary blood flow and to examine the accuracy of quantifying noninvasively by PCT myocardial 13NH3 tissue concentration and, hence, regional myocardial perfusion.
KeywordsMyocardial Perfusion Left Atrium Left Anterior Descend Myocardial Blood Flow Coronary Blood Flow
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- 2.Hunter W, Monahan WG (1971) 13N-ammonia: new physiologic radiotracer for molecular medicine. J Nucl Med 12: 368Google Scholar
- 4.Walsh WF, Harper PV, Resnekov L, Fill H (1976) Noninvasive evaluation of regional myocardial perfusion in 112 patients using a mobile scintillation camera and intravenous Nitrogen-13 labeled ammonia. Circulation 54: 226–275Google Scholar
- 13.Donato L, Bartolomei G, Giordani R (1964) Evaluation of myocardial perfusion in man with radioactive potassium or rubidium and precordial counting. Circulation 39: 195–203Google Scholar
- 17.Bassingthwaighte JB, Yipintsoi T (1970) The emergence function: Effects of flow and capillary-tissue exchange in the heart. In: (eds) Capillary permeability. Crone C, Lassen NA, Munksgaard, Copenhagen, pp 239–252Google Scholar
- 19.Klocke RA, Anderson KK, Rotman HH, et al (1972) Permeability of human erythrocytes to ammonia and weak acids. Am J Physiol 22: 1004–1013Google Scholar
- 23.Becker L, Ferreira R, Thomas M (1975) Comparison of 86and microsphere estimates of left ventricular blood flow distribution. J Nucl Med 15: 969–973Google Scholar
- 26.Hoffman EJ, Huang SC, Phelps ME (1978) Effect of object size in quantitative positron computed tomography (abstr). J Nucl Med 19: 683Google Scholar
- 27.Huang SC, Phelps ME, Hoffman EJ, et al (1978) Effects of inaccurate attenuation correction in emission computed tomography (abstr) J Nucl Med 19: 745Google Scholar
- 28.Gould KL, Schelbert HR, Phelps ME, Hoffman EJ (1979) Noninvasive assessment of coronary stenosis by myocardial perfusion imaging during pharmacologic coronary dilation. V. Detection of 47% diameter coronary stenosis with 13NH3 and emission computerized transaxial tomography in intact dogs. Am J Cardiol 43: 200–208PubMedCrossRefGoogle Scholar