Advertisement

The Effect of Beta Adrenergic Blocking Drugs on Left Ventricular Function in Thyrotoxicosis

  • P. Gulliford
  • M. Critchley
Conference paper

Summary

Propranolol is a beta adrenergic blocking drug used to diminish the tremor, palpitations and tachycardia of thyrotoxic patients. It reduces cardiac output and myocardial contractility. We have examined the effect of propranolol on the left ventricular function of 20 patients with hyperthyroidism. Serial changes in left ventricular volume, ejection fraction and systolic ejection rate were monitored, allowing the construction of time-activity curves before and after 40 mg of oral propranolol hydrochloride (Inderal). Using an equilibrium multiple gated technique with in vivo 99mTc red blood cell labelling, left ventricular performance was observed for as long as 3 h. In 20 patients treated with propranolol, the LVEF decreased by 20%, the maximum systolic ejection rate by 30% and the time of electromechanical systole increased by 25% over a 2-h period.

Keywords

Chronotropic Effect Systolic Time Interval Thyrotoxic Patient Beta Adrenergic Blocking Drug Electromechanical Systole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Linden RJ, Harry RD (1974) Goodwin Y (ed) Progress in cardiology. Lea & FebigerGoogle Scholar
  2. 2.
    Luig H, Emrich D, Breuel HP, Strauer BE, Neubaur J, Kisselbach VJ (1975) Non-invasive determination of volume equivalent curves of the left ventricle. IAEA Symposium Vienna, pp 207–217Google Scholar
  3. 3.
    Seeker Walker RH, Resnick L, Kunz H, Parker JA, Hill RL, Potchen EJ (1973) Measurement of left ventricular ejection fraction. J Nucl Med 14 (11): 798–802Google Scholar
  4. 4.
    Pitt B, Strauss HW (1977) Cardiovascular nuclear medicine. Semin Nucl Med 7 (1): 3–6PubMedCrossRefGoogle Scholar
  5. 5.
    Qureshi S, Wagner HN, Alderson PO, Housholder DF, Douglass KH, Lotter MG, Nickoloff EL, Tanabe M, Knowles LG (1978) Evaluation of left ventricular function in normal persons and patients with heart disease. J Nucl Med 19 (2): 135–141PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • P. Gulliford
    • 1
  • M. Critchley
    • 1
  1. 1.Department of Nuclear MedicineThe Liverpool ClinicLiverpoolUK

Personalised recommendations