13N-L-Amino Acids Synthesized Enzymatically for in vivo Metabolic Studies

  • A. S. Gelbard
Conference paper


Short-lived, positron-emitting radionuclides of nitrogen and carbon may be generated with a cyclotron and used to label biologically active compounds such as amino acids for in vivo metabolic studies. The 10-min half-life of nitrogen-13 results in relatively small radiation exposures to the patient; but it requires that the chemist develop new and rapid procedures to synthesize adequate amounts of radiolabeled compounds.


Enzymatic Synthesis Glutamate Dehydrogenase Cyanogen Bromide Label Amino Acid Amic Acid 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • A. S. Gelbard
    • 1
  1. 1.Biophysics LaboratoryMemorial Sloan-Kettering Cancer CenterNew YorkUSA

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