Can CO2 Be Actively Eliminated by the Lungs?

  • G. H. Gurtner
  • R. J. Traystman
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


A few years ago we presented our observation that in dogs, during rebreathing under conditions of no gas exchange, the alveolar \({{\text{P}}_{C{O_2}}}\) was higher than the \({{\text{P}}_{C{O_2}}}\) in the mixed venous blood (Gurtner et al., 1969). The phenomenon had been originally described by Bohr in 1891 who found that alveolar \({{\text{P}}_{C{O_2}}}\) was higher than arterial \({{\text{P}}_{C{O_2}}}\) when 5% to 10% CO2 was present in the inspired air. A similar observation had also teen made by Jones et al. (1967) during rebreathing experiments in exercising man a few years prior to our observations. Subsequently the pehnomenon has been reported by several groups of investigators including Guyatt et al. (1973) who did experiments similar to our own, and by Jennings and Chen (1975) who found results similar to those of Bohr. Recently, the phenomenon has been demonstrated to exist during normal gas exchange by Robertson and Hlastala (1977).


Base Excess Mixed Venous Blood Severe Hypercapnia Alveolar Capillary Membrane Wien Effect 
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  1. Bohr C (1891) Über die Lungenathmung. Scand Arch Physiol 2: 236–268Google Scholar
  2. Brown EB, Michel CC (1968) Whole body CO2 exchange. Proc Int Union Physiol Sci 6: 185–186Google Scholar
  3. Cohen JJ, Brackett Jr NC, Schwartz WB (1964) The nature of the carbon dioxide titration curve in the normal dog. J Clin Invest 43: 777–786CrossRefGoogle Scholar
  4. Forster RE, Crandall ED (1975) Time course of exchanges between red cells and extracellular fluid during CO2 uptake. J Appl Physiol 38: 710–718Google Scholar
  5. Gurtner GH (1972) Nonequilibrium steady-state differences in partial pressure of CO2 and in concentration of weak acids and bases between blood and tissue. Biophys J 12: 597–608CrossRefGoogle Scholar
  6. Gurtner GH (1977) Controversy: Can alveolar \( {{\text{P}}_{C{O_2}}} \) exceed pulmonary end capillary CO2? J Appl Physiol 42: 323–328Google Scholar
  7. Gurtner GH, Song SH, Farhi LE (1969) Alveolar to mixed-venous \({{\text{P}}_{C{O_2}}}\) difference under conditions of no gas exchange. Respir Physiol 7: 173–187CrossRefGoogle Scholar
  8. Guyatt AR, Yu CJ, Lutherer B, Otis AB (1973) Studies of alveolar-mixed venous CO2 and O2 gradients in the rebreathing dog lung. Respir Physiol 17: 178–194CrossRefGoogle Scholar
  9. Hill EP, Power GG, Longo LD (1973) Mathematical simulation of pulmonary O2 and CO2 exchange. Am J Physiol 224: 904–947Google Scholar
  10. Jennings DB, Chen CC (1975) Negative arterial mixed expired \({{\text{P}}_{C{O_2}}}\) gradient during acute and chronic hypercapnia. J Appl Physiol 38: 382–388Google Scholar
  11. Jones NL, Campbell EJM, McHardy GJR, Higgs BE, Clode M (1967) The estimation of carbon dioxide pressure of mixed venous blood during exercise. Clin Sci 32: 311–327Google Scholar
  12. Robertson HT, Hlastala MP (1977) Elevated alveolar \({{\text{P}}_{C{O_2}}}\) relative to predicted values during normal gas exchange. J Appl Physiol 43: 357–364Google Scholar
  13. Scheid P, Meyer M, Piiper J (1978) Gas/blood CO2 equilibration in dog lungs in hypercapnia. Pflögers Arch Suppl 37: R21Google Scholar
  14. Severinghaus JW (1966) Blood gas calculator. J Appl Physiol 21: 1108–1116Google Scholar
  15. Siggard-Andersen O (1963) Blood acid base alignment nomogram. Scand J Clin Lab Invest 15: 211–217CrossRefGoogle Scholar
  16. Traystman RJ, Gurtner GH, Permutt S (1976) Effect of severe hypercapnia on the circulatory system. Circulation 54: 11–13Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • G. H. Gurtner
  • R. J. Traystman
    • 1
  1. 1.Depts. of Medicine and Environmental Health SciencesThe Johns Hopkins Medical InstitutionsBaltimoreUSA

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