Abstract
The evidence that estrogens may have an etiologic role in various human tumors has been reviewed by Hertz (1976). The evidence is not conclusive, therefore it is necessary to turn to animal studies to obtain direct evidence that estrogens can be carcinogenic.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Dahl-Iversen E, Hamburger C, Jørgensen H (1942) Cystic glandular hyperplasia of the endometrium elucidated by therapeutic experiences in patients and by experiments on rhesus monkeys. Acta Obstet Gynecol Scand 5:315
Engle ET, Smith PE (1935) Some uterine effects obtained in female monkeys during continued oestrin administration, with especial reference to cervix uteri. Anat Rec 61:471
Engle ET, Krakower C, Haagensen CD (1943) Estrogen administration to aged female monkeys with no resultant tumors. Cancer Res 3:858
Gardner WU, Ferrigno M (1956) Unusual neoplastic lesions of the uterine horns of estrogen-treated mice. J Natl Cancer Inst 17:601
Hartman CG, Geschickter CF, Speert H (1941) Effects of continuous estrogen administration in very large doses. Anat Rec (Suppl 2 ) 79:31
Hertz R (1976) Steroid-induced, steroid-producing, and steroid-responsive tumors. In: Menon KMJ, Reel JR (eds) Steroid hormone action and cancer. Plenum, New York, pp 1–14
Hisaw FL, Lendrum FC (1936) Squamous metaplasia in the cervical glands of the monkey following oestrin administration 1,2. Endocrinology 20:228
Iglesias R, Lipschutz A (1947) Effects of prolonged oestrogen administration in female New World monkeys with observations on a pericardial neoplasm. Endocrinol 5:88
Jabara AG (1959) Canine ovarian tumours following stilboestrol administration. Aust J Exp Biol Med Sci 37:549
Lacomba T, Gabaldon M (1971) Biochemical studies of diethylstilbestrol-induced kidney tumors in the Golden Syrian hamster. Cancer Res 31:1251
Mawdesley-Thomas LE, Sortwell RJ (1968) Proliferative lesions of the canine uterus associated with high dose desterogen administration. Vet Rec 82:468
McClure HM, Graham CE (1973) Malignant uterine mesotheliomas in squirrel monkeys following diethylstilbestrol administration. Lab Anim Sci 23:493
Meissner WA, Sommers SC, Sherman G (1957) Endometrial hyperplasia, endometrial carcinoma, and endometriosis produced experimentally by estrogen. Cancer 10:500
Noble RL (1967) Induced transplantable estrogen-dependent carcinoma of the adrenal cortex in rats. Proc Am Assoc Cancer Res 8:51 (Abst /200)
Overholser MD, Allen E (1935) Atypical growth induced in cervical epithelium of the monkey by prolonged injections of ovarian hormone combined with chronic trauma. Surg Gynecol Obstet 60:129
Owen NV, Pierce EC, Anderson RC (1972) Papillomatous growths on internal genitalia of bitches administered the synthetic estrogen trans-4, 4-dimethyl-, -diethylstilbene. Toxicol Appl pharmacol 21:582
Rudali G, Coezy E, Frederic F, Apiou F (1971) Susceptibility of mice of different strains to the mammary carcinogenic action of natural and synthetic oestrogens. Eur J Clin & Biol Res 16:425
Scott RB, Wharton LR Jr, (1955) The effects of excessive amounts of diethylstilbestrol on experimental endometriosis in monkeys. Am J Obstet Gynecol 69:573
Shimkin MB, Grady HG, Andervont HB (1941) Induction of testicular tumors and other effects of stilbestrolcholesterol pellets in strain C mice. J Natl Cancer Inst 2: 65
Sonnnenschein C, Posner M, Sahr K, Farookhi R, Brunelle R (1974) Estrogen sensitive cell lines. Establishment and characterization of new cell lines from estrogen-induced rat pituitary tumors. Exp Cell Res 84:399
Zuckerman S (1937) Effects of prolonged oestrin-stimulation on the cervix uteri. Lancet 232:435
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Graham, C.E., McClure, H.M., Collins, D.C. (1980). Uterine Tumors in Nonhuman Primates After Estrogen Exposure. In: Dallenbach-Hellweg, G. (eds) Functional Morphologic Changes in Female Sex Organs Induced by Exogenous Hormones. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67568-3_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-67568-3_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-67570-6
Online ISBN: 978-3-642-67568-3
eBook Packages: Springer Book Archive