Clinical Relevance of the Determination of IgM in the Cerebrospinal Fluid with Special Reference to Multiple Sclerosis Patients
The determination of plasma proteins in cerebrospinal fluid (CSF) enables us to assess the filtration process through the blood-brain barrier. Their increase generally indicates the existence of an inflammatory reaction in neurological tissues. Particular attention has been paid to IgG because of its possible local origin, and its determination is now fairly common. On a theoretical basis, the determination of IgM in CSF should be more useful than that of IgG. Because IgM is less liable to gain access to CSF by mere transudation on account of its large molecular size, an increase in IgM concentration should be a better index of the local immune response. Moreover, IgM should become detectable at earlier stages of the immune process, as it is generally the first antibody to be produced. However, in practive, the determination of IgM in CSF is not easy, as it requires very sensitive methods.
KeywordsFiltration Albumin Agar EDTA Polyethylene
Unable to display preview. Download preview PDF.
- 2.Rádl J, van den Berg P, Voormolen M, Hendriks WDH, Schaefer UW (1974) Homogeneous immunoglobulins in sera of Rhesus monkeys after lethal irradiation and bone-marrow transplantation. Clin Exp Immunol 16:259–266Google Scholar
- 5.Williams AC, Mingioli ES, McFarland H, Tourtellotte WW, McFarlin DE (1978) Elevated CSF IgM in multiple sclerosis. Neurology (Minneap) 28:393Google Scholar